University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Rebecca E. Graff, ScD

Rebecca E. Graff, ScD

Assistant Professor, University of California, San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA

Cancer Center Program Memberships

Prostate Cancer

Research Summary

I am currently an Assistant Professor in the Department of Epidemiology and Biostatistics. Broadly speaking, my research interests reside in population-based cancer epidemiology. More specifically, my research at present focuses on: 1) discerning the shared genetic basis of seemingly distinct cancer types; 2) discerning the shared genetic basis of cancer and other chronic diseases; 3) determining the metabolomic basis of lethal prostate cancer; 4) examining the role of lifestyle factors in prostate cancer survivorship; and 5) examining the role of lifestyle factors in kidney cancer risk and survivorship. My work has afforded me the opportunity to gain expertise in a variety of study designs and in both established and novel analytical methods.

In addition to research, I am deeply committed to educating the next generation of scientists. As such, I co-direct Designing and Conducting Research at the School of Medicine, co-teach EPI 207 in the Department of Epidemiology and Biostatistics, and mentor students working toward their Master's Degree in Clinical Research.

Education

University of California, Berkeley, (Berkeley, CA) BA, 05/2006, Statistics
Harvard T.H. Chan School of Public Health, (Boston, MA) ScD, 05/2014, Cancer Epidemiology
University of California, San Francisco, (San Francisco, CA) Postdoctoral, 09/2018, Genetic Cancer Epidemiology

Honors & Awards

  • 2006
    Phi Beta Kappa with High Distinction in General Scholarship, University of California, Berkeley
  • 2011
    Distinction in Methods on the Written Qualifying Exam, Harvard T.H. Chan School of Public
    Health, Department of Epidemiology
  • 2012
    Best of Cancer Epidemiology, Biomarkers & Prevention
  • 2012
    Invited Attendee of the Society for Epidemiologic Research Student Dissertation Workshop
  • 2013
    American Association for Cancer Research Scholar-in-Training Award
  • 2015
    Invited Attendee of the American Association for Cancer Research Integrative Molecular
    Epidemiology Workshop
  • 2016
    Winner of the NCI's Up for a Challenge competition
  • 2017
    Selected for the NCI's Epidemiology and Genomics Research Program Research Highlights

Selected Publications

  1. Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, Jorgenson E, McBride RB, Graff RE, McGuire V, Achacoso N, Acton L, Liang RY, Lipson JA, Rubin DL, Yaffe MJ, Easton DF, Schaefer C, Risch N, Whittemore AS, Habel LA. Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk. Nat Commun. 2020 10 09; 11(1):5116.
    View on PubMed
  2. Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS. Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nat Commun. 2020 Sep 04; 11(1):4423.
    View on PubMed
  3. Hayes-Larson E, Ackley SF, Zimmerman SC, Ospina-Romero M, Glymour MM, Graff RE, Witte JS, Kobayashi LC, Mayeda ER. The competing risk of death and selective survival cannot fully explain the inverse cancer-dementia association. Alzheimers Dement. 2020 Sep 03.
    View on PubMed
  4. Purdue MP, Song L, Scélo G, Houlston RS, Wu X, Sakoda LC, Thai K, Graff RE, Rothman N, Brennan P, Chanock SJ, Yu K. Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations. Cancer Epidemiol Biomarkers Prev. 2020 Oct; 29(10):2065-2069.
    View on PubMed
  5. Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC. The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship. Alzheimer Dis Assoc Disord. 2020 Jun 19.
    View on PubMed
  6. Meyers TJ, Weiner AB, Graff RE, Desai AS, Cooley LF, Catalona WJ, Hanauer SB, Wu JD, Schaeffer EM, Abdulkadir SA, Kundu SD, Witte JS. Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study. Int J Cancer. 2020 Nov 15; 147(10):2735-2742.
    View on PubMed
  7. Khan S, Caldwell J, Wilson KM, Gonzalez-Feliciano AG, Peisch S, Pernar CH, Graff RE, Giovannucci EL, Mucci LA, Gerke TA, Markt SC. Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study. Cancer Epidemiol Biomarkers Prev. 2020 Jun; 29(6):1229-1236.
    View on PubMed
  8. Kyle B. Zuniga, Rebecca E. Graff, David B. Feiger, Maxwell V. Meng, Sima P. Porten, Stacey A. Kenfield. Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions. Bladder Cancer. 2020; 6(1):9-23.
    View on PubMed
  9. Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C, Goodman GE, Doherty JA, Bickeböller H, Field JK, Davies MP, Dawn Teare M, Kiemeney LA, Bojesen SE, Haugen A, Zienolddiny S, Lam S, Le Marchand L, Cheng I, Schabath MB, Duell EJ, Andrew AS, Manjer J, Lazarus P, Arnold S, McKay JD, Emami NC, Warkentin MT, Brhane Y, Obeidat M, Martin RM, Relton C, Davey Smith G, Haycock PC, Amos CI, Brennan P, Witte JS, Hung RJ. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nat Commun. 2020 01 07; 11(1):27.
    View on PubMed
  10. Hashim D, Gonzalez-Feliciano AG, Ahearn TU, Pettersson A, Barber L, Pernar CH, Ebot EM, Isikbay M, Finn SP, Giovannucci EL, Lis RT, Loda M, Parmigiani G, Lotan T, Kantoff PW, Mucci LA, Graff RE. Family history of prostate cancer and the incidence of ERG- and phosphatase and tensin homolog-defined prostate cancer. Int J Cancer. 2020 May 15; 146(10):2694-2702.
    View on PubMed
  11. Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou CK, Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Li Z, Pollak M, Mucci LA. Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease. Carcinogenesis. 2018 12 31; 39(12):1431-1437.
    View on PubMed
  12. Pernar CH, Ebot EM, Pettersson A, Graff RE, Giunchi F, Ahearn TU, Gonzalez-Feliciano AG, Markt SC, Wilson KM, Stopsack KH, Gazeeva E, Lis RT, Parmigiani G, Rimm EB, Finn SP, Giovannucci EL, Fiorentino M, Mucci LA. A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG. Eur Urol. 2019 07; 76(1):33-40.
    View on PubMed
  13. Graff RE, Kachuri L, Witte JS. Personalized Prostate Cancer Screening Based on a Single Midlife Prostate-specific Antigen Measurement. Eur Urol. 2019 03; 75(3):408-409.
    View on PubMed
  14. Stopsack KH, Gonzalez-Feliciano AG, Peisch SF, Downer MK, Gage RA, Finn S, Lis RT, Graff RE, Pettersson A, Pernar CH, Loda M, Kantoff PW, Ahearn TU, Mucci LA. A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1231-1233.
    View on PubMed
  15. Graff RE, Cho E, Preston MA, Sanchez A, Mucci LA, Wilson KM. Dietary Acrylamide Intake and Risk of Renal Cell Carcinoma in Two Large Prospective Cohorts. Cancer Epidemiol Biomarkers Prev. 2018 08; 27(8):979-982.
    View on PubMed
  16. Graff RE, Sanchez A, Tobias DK, Rodríguez D, Barrisford GW, Blute ML, Li Y, Sun Q, Preston MA, Wilson KM, Cho E. Type 2 Diabetes in Relation to the Risk of Renal Cell Carcinoma Among Men and Women in Two Large Prospective Cohort Studies. Diabetes Care. 2018 07; 41(7):1432-1437.
    View on PubMed
  17. Graff RE, Mucci LA, Hjelmborg JB. Reply. Clin Gastroenterol Hepatol. 2018 02; 16(2):298-299.
    View on PubMed
  18. Graff RE, Ahearn TU, Pettersson A, Ebot EM, Gerke T, Penney KL, Wilson KM, Markt SC, Pernar CH, Gonzalez-Feliciano AG, Song M, Lis RT, Schmidt DR, Vander Heiden MG, Fiorentino M, Giovannucci EL, Loda M, Mucci LA. Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2018 02; 27(2):193-200.
    View on PubMed
  19. Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS. Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics. Cancer Epidemiol Biomarkers Prev. 2018 01; 27(1):75-85.
    View on PubMed
  20. Hoffman JD, Graff RE, Emami NC, Tai CG, Passarelli MN, Hu D, Huntsman S, Hadley D, Leong L, Majumdar A, Zaitlen N, Ziv E, Witte JS. Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. PLoS Genet. 2017 Mar; 13(3):e1006690.
    View on PubMed

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