University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Janine M. Lupo, PhD

Janine M. Lupo, PhD

Assistant Professor, Dept. of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

Janine Lupo, PhD, is an Associate Professor in the Surbeck Laboratory of Advanced Imaging and Neuroimaging Research Interest Group of the Department of Radiology and Biomedical Imaging. She is a member of the UCSF/UC Berkeley Graduate Group in Bioengineering, Helen Diller Family Comprehensive Cancer Center, Institute for Computational Health Sciences, and Quantitative Biosciences Institute. Dr. Lupo received her BSE in Bioengineering at the University of Pennsylvania, School of Engineering and Applied Science in Philadelphia before completing her PhD at the UCSF/UCB PhD Joint Graduate Group in Bioengineering. Before accepting the Assistant Professor position, Dr. Lupo was an Assistant and Associate Researcher in the Department of Radiology and Biomedical Imaging at UCSF.

Dr. Lupo’s research focuses on the development and application of novel MR imaging data acquisition, processing, and analysis techniques for the evaluation of patients with brain tumors and other neurological diseases using our research 3T and 7T whole body scanners. This includes the development of quantitative algorithms critical for processing data from advanced acquisitions for patient studies, implementation of statistical models to relate imaging markers with biological characteristics from pathology and clinical outcome in order to both identify patients who would benefit most for a given therapy, and monitor the effects of therapy over time on tumor control, normal brain tissue structure, and cognition.

Dr. Lupo is the Principal or Co-Principal Investigator for two NIH grants, as well as the Director of an Imaging Core within an NIH Programmatic Project grant. She has published over 40 research articles.

Expertise:

Bioengineering

Specialty:

Neuroimaging

Professional Interests:

Bioengineering, magnetic resonance imaging, ultra-high field MRI, algorithm development, quantitative analysis, imaging biomarker discovery, brain cancer, neurological diseases, evaluation of therapy, the effects of therapy on cognition, statistical modeling and machine learning

Education

University of Pennsylvania, Philadelphia, PA, BSE, 9/1997 – 5/2001, Bioengineering
University of California, San Francisco & Berkeley PhD 8/2001 – 8/2006, Bioengineering
University of California, San Francisco Post-Doc 9/2006 – 3/2010 High Field MRI of Brain


Professional Experience

  • 2016-present
    Assistant Professor in residence, Department of Radiology & Biomedical Imaging, UCSF
  • 2014-2015
    Associate Researcher, Department of Radiology & Biomedical Imaging, UCSF
  • 2010-2014
    Assistant Researcher, Department of Radiology & Biomedical Imaging, UCSF
  • 2006-2010
    Postdoctoral Fellow, Department of Radiology, University of California, San Francisco
  • 2004-2006
    Instructor, MR Physics and Instrumentation, Sonoma College, San Francisco and Petaluma

Honors & Awards

  • 2012
    UCSF RAP Grants Novel Clinical/Translational Methods Award
  • 2012
    National Institutes of Health Clinical Loan Repayment Program Continuation Award Recipient
  • 2011
    UCSF Radiology Symposium Poster Award
  • 2010
    National Institutes of Health Clinical Loan Repayment Program Award Recipient
  • 2010
    Honorable Mention Poster Award, UCSF Bioengineering & Therapeutic Sciences Symposium
  • 2010
    Neuroimaging Poster Award Nomination, ISMRM conference
  • 2008
    UCSF Radiology Symposium Poster Award
  • 2006
    Surbeck Scholar Award
  • 2003
    UCSF Graduate Research Award

Selected Publications

  1. Majumdar S, Lupo J, Vigneron D, Ronen S, Kurhanewicz J, Hess C. In memoriam: Sarah J. Nelson, January 26, 1954-April 3, 2019. Magn Reson Med. 2019 May 17.
    View on PubMed
  2. Morrison MA, Hess CP, Clarke JL, Butowski N, Chang SM, Molinaro AM, Lupo JM. Risk factors of radiotherapy-induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors. J Magn Reson Imaging. 2019 Jan 20.
    View on PubMed
  3. Chen Y, Villanueva-Meyer JE, Morrison MA, Lupo JM. Toward Automatic Detection of Radiation-Induced Cerebral Microbleeds Using a 3D Deep Residual Network. J Digit Imaging. 2018 Dec 03.
    View on PubMed
  4. Villanueva-Meyer JE, Chang P, Lupo JM, Hess CP, Flanders AE, Kohli M. Machine Learning in Neurooncology Imaging: From Study Request to Diagnosis and Treatment. AJR Am J Roentgenol. 2019 Jan; 212(1):52-56.
    View on PubMed
  5. Park I, Lupo JM, Nelson SJ. Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma. Mol Imaging Biol. 2018 Sep 17.
    View on PubMed
  6. Vareth M, Lupo J, Larson P, Nelson S. A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors. NMR Biomed. 2018 11; 31(11):e3929.
    View on PubMed
  7. Morrison MA, Payabvash S, Chen Y, Avadiappan S, Shah M, Zou X, Hess CP, Lupo JM. A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning. Neuroimage Clin. 2018; 20:498-505.
    View on PubMed
  8. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903.
    View on PubMed
  9. Wahl M, Anwar M, Hess CP, Chang SM, Lupo JM. Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126.
    View on PubMed
  10. Wahl M, Chang SM, Phillips JJ, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639.
    View on PubMed
  11. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 09; 188(3):303-313.
    View on PubMed
  12. Zou X, Hart BL, Mabray M, Bartlett MR, Bian W, Nelson J, Morrison LA, McCulloch CE, Hess CP, Lupo JM, Kim H. Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations. Neuroradiology. 2017 Jul; 59(7):685-690.
    View on PubMed
  13. Roddy E, Sear K, Felton E, Tamrazi B, Gauvain K, Torkildson J, Buono BD, Samuel D, Haas-Kogan DA, Chen J, Goldsby RE, Banerjee A, Lupo JM, Molinaro AM, Fullerton HJ, Mueller S. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016 11; 18(11):1548-1558.
    View on PubMed
  14. Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179.
    View on PubMed
  15. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 08; 18(8):1169-79.
    View on PubMed
  16. Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ. Investigating tumor perfusion by hyperpolarized 13 C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts. Magn Reson Med. 2017 02; 77(2):841-847.
    View on PubMed
  17. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55.
    View on PubMed
  18. Chaumeil MM, Lupo JM, Ronen SM. Magnetic Resonance (MR) Metabolic Imaging in Glioma. Brain Pathol. 2015 Nov; 25(6):769-80.
    View on PubMed
  19. Wen Q, Kelley DA, Banerjee S, Lupo JM, Chang SM, Xu D, Hess CP, Nelson SJ. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T. Neuroimage Clin. 2015; 9:291-9.
    View on PubMed
  20. Lupo JM, Molinaro AM, Essock-Burns E, Butowski N, Chang SM, Cha S, Nelson SJ. The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma. Neuro Oncol. 2016 Jan; 18(1):87-95.
    View on PubMed

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