Research Summary

I have significant experience conducting international, multi-center trials through established consortia, such as the Children's Oncology Group and the Pacific Pediatric Neuro-Oncology Consortium (PNOC), which I am leading. The current emphasis of PNOC lies in the development and rapid implementation of early phase clinical trials as well as to enhance access to innovative therapies through international collaborations including Europe, Israel, Egypt, Canada and Australia for children and young adults with brain tumors. I also lead a multi-site late effects cohort study (Rad ART) and collaborate with the Childhood Cancer Survivor Study for my late effect research.

Education

College, University of Hamburg, Germany  M.S.,  01/95,  Biochemistry
MD/PhD program, University of Hamburg,  M.D./Ph.D.,  01/03,  Chemistry
Harvard Medical School, Boston,  Intern,  01/05,  Pediatrics
Harvard Medical School, Boston,  Resident,  01/06,  Pediatrics
UCSF,  Clinical  Fellow,  06/09,  Child Neurology
UCSF,  Clinical  Fellow,  06/10,  Neuro-Oncology

Honors & Awards

  • 2019
    Eliminate Cancer Initiative Collaborative Team Science Award
  • 2018
    UCSF CTSI Yearlong Inquiry Fellowship Mentor of the Year Award
  • 2017
    UCSF Pediatric Fellow Mentorship Award
  • 2017
    UCSF Medical Center Exceptional Physician Award
  • 2015
    Research Award from the Matthew Larson Foundation
  • 2015
    Kure It Research Award
  • 2014
    Nominee of UCSF Medical Center's Exceptional Physician Award
  • 2013
    Award Winning Abstract Annual Meeting of the Society of Neuro-Oncology
  • 2012
    Research Award from the Matthew Larson Foundation
  • 2012
    KL2 CTSI Award
  • 2012
    Hellman Family Research Award
  • 2012
    University of California Cancer Coordinating Committee Award
  • 2011
    BRAIN SPORE Career Development Award
  • 2010
    Research Award from the Campini Foundation
  • 2008
    Chief Resident, Department of Neurology, UCSF
  • 2007
    Travel scholarship to attend the Annual Meeting of Neurology
  • 1999
    Center of Molecular Neurobiology (ZMNH) AACR research/travel award,Philadelphia, PA
  • 1999
    Bauer Stiftung Predoctoral Fellowship, Hamburg, Germany
  • 1998
    European Society of Neurobiology research/travel award, Berlin, Germany
  • 1997
    Center of Molecular Neurobiology (ZMNH) Predoctoral Fellowship, Hamburg,Germany

Selected Publications

  1. Erker C, Mynarek M, Simbozel M, Craig BT, Harrod VL, Cappellano AM, Cohen KJ, Lopez VS, Morales La Madrid A, Cacciotti C, Baroni L, Salloum R, Margol AS, Michaiel G, Aguilera D, Mazewski CM, Kline CN, Finlay JL, Abdelbaki MS, Murray JC, Dorris K, Crooks B, Ginn KF, Amayiri N, Tippelt S, Fleischhack G, Tonn S, Gerber NU, Lassaletta A, Hansford JR, Khan S, Gilheeney SW, Hoffman LM, Zapotocky M, Larouche V, Shah S, Ramaswamy V, Gajjar A, Perreault S, Mueller S, Hukin J, Cheng S, Wang ZJ, Matheson K, Bailey S, Bouffet E, Clifford SC, Robinson G, Dufour C, Rutkowski S, Lafay-Cousin L Salvage therapies for first relapse of SHH medulloblastoma in early childhood.  View on PubMed
  2. Mateos MK, Ajuyah P, Fuentes-Bolanos N, El-Kamand S, Barahona P, Altekoester AK, Mayoh C, Holliday H, Liu J, Cui L, Pfaff E, Mackay A, Resnick AC, Pinese M, Lau LMS, Khuong-Quang DA, Dias K, Goudie C, Salkeld A, Rokita JL, Jones DTW, Juretic N, Hayden E, Pfister SM, Kramm CM, Blattner-Johnson M, Jabado N, Tsoli M, Vittorio O, Mueller S, Guo Y, Tucker K, Waszak SM, Perreault S, Jones C, Wong-Erasmus M, Cowley MJ, Ziegler DS Germline analysis of an international cohort of pediatric diffuse midline glioma patients.  View on PubMed
  3. Yu B, Kline C, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn J, Banerjee A, Leary S, Crotty E, Abdelbaki M, Whipple N, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips J, Prados M, Molinaro A, Gupta N, Raffel C, Cole K, Kasahara N, Diaz AA, Mueller S Measles Oncolytic Virus as an Immunotherapy for Recurrent/Refractory Pediatric Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor: Results from PNOC005.  View on PubMed
  4. Fathi Kazerooni A, Kraya A, Rathi KS, Kim MC, Kesherwani V, Corbett R, Vossough A, Khalili N, Gandhi D, Khalili N, Familiar AM, Jin R, Huang X, Zhu Y, Sickler A, Lueder MR, Phul S, Storm PB, Ware JB, Foster JB, Mueller S, Rokita JL, Fisher MJ, Resnick AC, Nabavizadeh A Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.  View on PubMed
  5. Kilburn LB, Khuong-Quang DA, Hansford JR, Landi D, van der Lugt J, Leary SES, Driever PH, Bailey S, Perreault S, McCowage G, Waanders AJ, Ziegler DS, Witt O, Baxter PA, Kang HJ, Hassall TE, Han JW, Hargrave D, Franson AT, Yalon Oren M, Toledano H, Larouche V, Kline C, Abdelbaki MS, Jabado N, Gottardo NG, Gerber NU, Whipple NS, Segal D, Chi SN, Oren L, Tan EEK, Mueller S, Cornelio I, McLeod L, Zhao X, Walter A, Da Costa D, Manley P, Blackman SC, Packer RJ, Nysom K Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.  View on PubMed
  6. Climent Pardo JC, Zapaishchykova A, Boyd A, Tak D, Zielke J, Mahootiha M, Ye Z, Vajapeyam S, Jones J, Smith C, Familiar AM, Nabavizadeh A, Bandopadhayay P, Mueller S, Aerts HJWL, Haas-Kogan DA, Michor F, Ligon KL, Poussaint TY, Faghihroohi S, Kann BH Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study.  View on PubMed
  7. Subramaniam B, Roy D, Woldegerima A, Chong WC, Przystal JM, Zhang J, Laternser S, Kritzer B, Rangnath S, Knowles T, Yadavilli S, Packer R, Mueller S, Nazarian J Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models.  View on PubMed
  8. Hawkins C, Aldape K, Capper D, von Deimling A, Giannini C, Gilbert MR, Jacques TS, Jones D, Komori T, Louis DN, Mueller S, Nasrallah M, Orr BA, Perry A, Pfister SM, Sahm F, Sarkar C, Snuderl M, Solomon D, Varlet P, Wesseling P, Reifenberger G cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification.  View on PubMed
  9. Mueller S, Kline C, Lu AY, Hoogendijk R, Wembacher-Schroeder E, Banerjee A, Reddy AT, Raber S, Hoffman C, Stoller S, Prados M, Molinaro A, Gupta N PNOC009: Convection-enhanced delivery of liposomal irinotecan in patients with newly diagnosed diffuse intrinsic pontine glioma.  View on PubMed
  10. Tak D, Garomsa BA, Zapaishchykova A, Ye Z, Vajapeyam S, Mahootiha M, Pardo JCC, Smith C, Familiar AM, Chaunzwa TL, Liu KX, Prabhu SP, Bandopadhayay P, Nabavizadeh A, Mueller S, Aerts HJWL, Haas-Kogan D, Poussaint TY, Kann BH Longitudinal Risk Prediction for Pediatric Glioma with Temporal Deep Learning.  View on PubMed
  11. van Ommen F, van Genechten T, Willemsen-Bosman ME, Peters M, Seravalli E, van der Lugt J, Nievelstein RAJ, Mueller S, Hulleman E, van Vuurden DG, Kranendonk MEG, Hoving EW, Hoeben BAW, Janssens GO Gross tumor volume increase and need for adaptive radiotherapy in pediatric-type diffuse high-grade glioma of the midline structures.  View on PubMed
  12. Mayr L, Neyazi S, Schwark K, Trissal M, Beck A, Labelle J, Eder SK, Weiler-Wichtl L, Marques JG, de Biagi-Junior CAO, Lo Cascio C, Chapman O, Sridhar S, Kenkre R, Dutta A, Wang S, Wang J, Hack O, Nascimento A, Nguyen CM, Castellani S, Rozowsky JS, Groves A, Panditharatna E, Cruzeiro GAV, Haase RD, Tabatabai K, Madlener S, Wadden J, Adam T, Kong S, Miclea M, Patel T, Bruckner K, Senfter D, Lämmerer A, Supko J, Guntner AS, Palova H, Neradil J, Stepien N, Lötsch-Gojo D, Berger W, Leiss U, Rosenmayr V, Dorfer C, Dieckmann K, Peyrl A, Azizi AA, Baumgartner A, Slaby O, Pokorna P, Clark LM, Cameron A, Nguyen QD, Wakimoto H, Dubois F, Greenwald NF, Bandopadhayay P, Beroukhim R, Ligon K, Kramm C, Bronsema A, Bailey S, Stucklin AG, Mueller S, Skrypek M, Martinez N, Bowers DC, Jones DTW, Jones C, Jäger N, Sterba J, Müllauer L, Haberler C, Kumar-Sinha C, Chinnaiyan A, Mody R, Chavez L, Furtner J, Koschmann C, Gojo J, Filbin MG Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.  View on PubMed
  13. Joshi N, Mueller S, Kline C Current clinical trials for craniopharyngiomas: what's on the horizon?  View on PubMed
  14. Haddadi Avval A, Banerjee S, Zielke J, Kann B, Mueller S, Rauschecker AM. Applications of Artificial Intelligence and Advanced Imaging in Pediatric Diffuse Midline Glioma. Neuro Oncol. 2025 Mar 03.  View on PubMed
  15. Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2025 Mar 03; 15(3):657.  View on PubMed
  16. Lamoureux AA, Fisher MJ, Lemelle L, Pfaff E, Amir-Yazdani P, Kramm C, De Wilde B, Kazanowska B, Hutter C, Pfister SM, Sturm D, Jones DTW, Orbach D, Pierron G, Raskin S, Drilon A, Diamond EL, Harada G, Zapotocky M, Zamecnik J, Krskova L, Ellezam B, Weil AG, Venne D, Barritault M, Leblond P, Coltin H, Hammad R, Tabori U, Hawkins C, Hansford JR, Meyran D, Erker C, McFadden K, Sato M, Gottardo NG, Dholaria H, Nørøxe DS, Goto H, Ziegler DS, Lin FY, Parsons DW, Lindsay H, Wong TT, Liu YL, Wu KS, Franson AT, Hwang E, Aguilar-Bonilla A, Cheng S, Cacciotti C, Massimino M, Schiavello E, Wood P, Hoffman LM, Cappellano A, Lassaletta A, Van Damme A, Llort A, Gerber NU, Spalato Ceruso M, Bendel AE, Skrypek M, Hamideh D, Mushtaq N, Walter A, Jabado N, Alsahlawi A, Farmer JP, Coleman C, Mueller S, Mazewski C, Aguilera D, Robison NJ, O'Halloran K, Abbou S, Berlanga P, Geoerger B, Øra I, Moertel CL, Razis ED, Vernadou A, Ducray F, Bronnimann C, Seizeur R, Clarke M, Resnick AC, Alves M, Jones C, Doz F, Laetsch TW, Perreault S Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.  View on PubMed
  17. Corbett RJ, Gullickson CC, Geng Z, Brown MA, Zhang B, Zhong C, Van Kuren N, Chroni A, Blackden C, Naqvi AS, Plisiewicz A, McHugh S, Drake E, Lehmann K, Davidson TB, Prados M, Storm PB, Resnick AC, Waanders AJ, Waszak SM, Mueller S, Rokita JL, Kline C. Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the PBTA and PNOC. Neuro Oncol. 2025 Jan 23.  View on PubMed
  18. Pearson AD, Mueller S, Filbin MG, Grill J, Hawkins C, Jones C, Donoghue M, Drezner N, Weiner S, Russo M, Dun MD, Allen JE, Alonso M, Benaim E, Buenger V, de Rojas T, Desserich K, Fox E, Friend J, Glade Bender J, Hargrave D, Jensen M, Kholmanskikh O, Kieran MW, Knoderer H, Koschmann C, Lesa G, Ligas F, Lipsman N, Ludwinski D, Marshall L, McDonough J, McNicholl AG, Mirsky D, Monje M, Nysom K, Pappo A, Rosenfield A, Scobie N, Slaughter J, Smith M, Souweidane M, Straathof K, Ward L, Weigel B, Zamoryakhin D, Karres D, Vassal G Paediatric strategy forum for medicinal product development in diffuse midline gliomas in children and adolescents ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.  View on PubMed
  19. Mahootiha M, Tak D, Ye Z, Zapaishchykova A, Likitlersuang J, Climent Pardo JC, Boyd A, Vajapeyam S, Chopra R, Prabhu SP, Liu KX, Elhalawani H, Nabavizadeh A, Familiar A, Mueller S, Aerts HJWL, Bandopadhayay P, Ligon KL, Haas-Kogan D, Poussaint TY, Qadir HA, Balasingham I, Kann BH Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas.  View on PubMed
  20. Aldape K, Capper D, von Deimling A, Giannini C, Gilbert MR, Hawkins C, Hench J, Jacques TS, Jones D, Louis DN, Mueller S, Orr BA, Nasrallah M, Pfister SM, Sahm F, Snuderl M, Solomon D, Varlet P, Wesseling P cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics.  View on PubMed

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