Pediatric Malignancies Program

Program Leaders

Education and Training Liaison: Christine Higham, MD

Community Engagement Liaison: Lena Winestone, MD

The goal of the PE Program is to advance the development of new therapies for pediatric cancer by enabling basic, translational, and clinical research with the goal of developing new effective targeted therapies for children with minimal toxicities.

Pediatric malignancies encompass a range of tumor types, and Pediatric Malignancies Program members are focused on diverse cancers, including leukemias, brain tumors, and sarcoma. Many of these are embryonal tumors, cancers that begin in embryonic tissues and that often represent failure of normal differentiation.


Pediatric Malignancies Program member research is organized around the following aims:

  • Aim 1: To discover and validate novel targets for pediatric cancer
  • Aim 2: To enable new therapeutic strategies to improve outcomes for pediatric cancer patients
  • Aim 3: To understand the link between pediatric cancer and normal development