University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Melike Pekmezci, MD

Melike Pekmezci, MD

Assistant Professor of Clinical Pathology, Depts. of Anatomic Pathology and Ophthalmology, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

  • Hacettepe University Faculty of Medicine, M.D., 06/2004
  • Gazi University, Department of Ophthalmology, Resident, 04/2007 (Ophthalmology)
  • University of California San Francisco, Department of Ophthalmology, Research fellow, 07/2009 (Ophthalmology)
  • Loyola University Medical Center, Department of Pathology, Resident, 06/2011 (Pathology)
  • University of California San Francisco, Department of Pathology, Resident, 06/2012 (Pathology)
  • University of California San Francisco, Department of Pathology, Clinical fellow, 06/2014 (Neuropathology)
  • University of California San Francisco, Department of Pathology, Clinical Fellow, 06/2015 (Surgical Pathology)
  • University of California San Francisco, Department of Pathology, Clinical fellow, 06/2016 (Surgical Pathology and Cytopathology)

Professional Experience

  • 08/2007-07/2008
    Research Assistant, Department of Ophthalmology, Washington University in St. Louis
  • 08/2008-07/2009
    Junior Specialist/ Research Fellow, Department of Ophthalmology, UCSF
  • 08/2009-06/2010
    Research Assistant, Department of Pathology, UCSF
  • 07/2012-06/2014
    Clinical Fellow in Neuropathology, Department of Pathology, UCSF
  • 07/2014-06/2015
    Clinical Fellow in Surgical Pathology, Department of Pathology, UCSF
  • 07/2015-06/2016
    Clinical Fellow in Surgical and Cytopathology, Department of Pathology, UCSF
  • 07/2016-present
    Assistant Professor of Clinical Pathology, Department of Anatomic Pathology, UCSF

Selected Publications

  1. Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A. Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker. Acta Neuropathol. 2020 Jan 07.
    View on PubMed
  2. Lee JC, Villanueva-Meyer JE, Ferris SP, Cham EM, Zucker J, Cooney T, Gilani A, Kleinschmidt-DeMasters BK, Trembath D, Mafra M, Chiang J, Ellison DW, Cho SJ, Horvai AE, Van Ziffle J, Onodera C, Devine P, Grenert JP, de Voijs CMA, van Blokland WTM, de Leng WWJ, Ploegmakers MJ, Flucke U, Pekmezci M, Bollen AW, Tihan T, Koelsche C, von Deimling A, Wesseling P, Solomon DA, Perry A. Clinicopathologic and Molecular Features of Intracranial Desmoplastic Small Round Cell Tumors. Brain Pathol. 2019 Dec 14.
    View on PubMed
  3. Asa SL, Asioli S, Bozkurt S, Casar-Borota O, Chinezu L, Comunoglu N, Cossu G, Cusimano M, Delgrange E, Earls P, Ezzat S, Gazioglu N, Grossman A, Guaraldi F, Hickman RA, Ikeda H, Jaffrain-Rea ML, Karavitaki N, Kraljevic I, La Rosa S, Manojlovic-Gacic E, Maartens N, McCutcheon IE, Messerer M, Mete O, Nishioka H, Oz B, Pakbaz S, Pekmezci M, Perry A, Reiniger L, Roncaroli F, Saeger W, Söylemezoglu F, Tachibana O, Trouillas J, Turchini J, Uccella S, Villa C, Yamada S, Yarman S. Pituitary neuroendocrine tumors (PitNETs): nomenclature evolution, not clinical revolution. Pituitary. 2019 Dec 13.
    View on PubMed
  4. Garakani R, Kersten R, Pekmezci M. Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland. Ophthalmic Plast Reconstr Surg. 2019 Nov 13.
    View on PubMed
  5. Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Alva E, Johnston J, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features. Brain Pathol. 2019 Oct 14.
    View on PubMed
  6. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 Nov; 138(5):877-881.
    View on PubMed
  7. Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg TD, Braunstein SE, Sneed PK, Perry A, Zadeh G, McDermott MW, Villanueva-Meyer JE, Raleigh DR. Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival. Neurooncol Adv. 2019 May-Dec; 1(1):vdz011.
    View on PubMed
  8. Rodriguez FJ, Graham MK, Brosnan-Cashman JA, Barber JR, Davis C, Vizcaino MA, Palsgrove DN, Giannini C, Pekmezci M, Dahiya S, Gokden M, Noë M, Wood LD, Pratilas CA, Morris CD, Belzberg A, Blakeley J, Heaphy CM. Telomere alterations in neurofibromatosis type 1-associated solid tumors. Acta Neuropathol Commun. 2019 Aug 28; 7(1):139.
    View on PubMed
  9. Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol. 2020 Jan; 30(1):46-62.
    View on PubMed
  10. Eckel-Passow JE, Decker PA, Kosel ML, Kollmeyer TM, Molinaro AM, Rice T, Caron AA, Drucker KL, Praska CE, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Erickson BJ, Lucchinetti CF, Wiemels JL, Wiencke JK, Bondy ML, Melin B, Burns TC, Giannini C, Lachance DH, Wrensch MR, Jenkins RB. Using germline variants to estimate glioma and subtype risks. Neuro Oncol. 2019 03 18; 21(4):451-461.
    View on PubMed
  11. Shamir ER, Chen YY, Chu T, Pekmezci M, Rabban JT, Krings G. Pleomorphic and Florid Lobular Carcinoma In Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center. Am J Surg Pathol. 2019 03; 43(3):399-408.
    View on PubMed
  12. Lee JC, Sharifai N, Dahiya S, Kleinschmidt-DeMasters BK, Rosenblum MK, Reis GF, Samuel D, Siongco AM, Santi M, Storm PB, Ferris SP, Bollen AW, Pekmezci M, Solomon DA, Tihan T, Perry A. Clinicopathologic features of anaplastic myxopapillary ependymomas. Brain Pathol. 2019 01; 29(1):75-84.
    View on PubMed
  13. Morshed RA, Han SJ, Hervey-Jumper SL, Pekmezci M, Troncon I, Chang SM, Butowski NA, Berger MS. Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60. J Neurooncol. 2019 Jan; 141(2):383-391.
    View on PubMed
  14. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2019 01; 29(1):85-96.
    View on PubMed
  15. Shamir ER, Devine WP, Pekmezci M, Umetsu SE, Krings G, Federman S, Cho SJ, Saunders TA, Jen KY, Bergsland E, Jones K, Kim GE, Kakar S, Chiu CY, Joseph NM. Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinoma. Mod Pathol. 2019 02; 32(2):290-305.
    View on PubMed
  16. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 01; 137(1):139-150.
    View on PubMed
  17. Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Villanueva-Meyer JE, Pekmezci M, Bollen AW, Perry A. Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile. Acta Neuropathol. 2018 08; 136(2):339-343.
    View on PubMed
  18. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 06 07; 6(1):47.
    View on PubMed
  19. Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S. Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST. Oncotarget. 2018 May 01; 9(33):23018-23028.
    View on PubMed
  20. Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR. Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation. Cell Rep. 2018 03 27; 22(13):3672-3683.
    View on PubMed

Go to UCSF Profiles, powered by CTSI