University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Suzaynn F. Schick, PhD

Suzaynn F. Schick, PhD

Associate Professor, UCSF School of Medicine, Division of Occupational and Environmental Medicine

Cancer Center Program Memberships

Tobacco Control

Research Summary

I study the health effects of air pollution in human subjects. I focus on the chemistry and toxicity of smoke and on how smoking and using electronic cigarettes can cause heart and lung disease. My analysis of tobacco industry research showed that sidestream cigarette smoke (the primary constituent of secondhand cigarette smoke) is more toxic than the smoke that smokers inhale and that secondhand smoke becomes more toxic as it ages.

I have published three controlled human exposure studies on the health effects of secondhand cigarette smoke which show that:

1. A single 30-minute exposure to fresh sidestream cigarette smoke, at 350 micrograms of particles per cubic meter, decreases flow-mediated dilation of the brachial artery and increases plasma VEGF and endothelial progenitor cell motility. (These changes can increase the risk of heart attack.)

2. For each increase in SHS exposure by 100 µg/m3 particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. (Even a little smoke can increase the risk of heart disease.)

3. A single 30-minute exposure to aged cigarette smoke, at 1000 µg/m3 particles, increases nasal congestion in healthy human subjects. (Nasal congestion can lead to sinus infections.)

My research on the chemistry and toxicity of cigarette smoke has helped define a new health risk from smoking: thirdhand cigarette smoke. Thirdhand smoke is the tiny droplets of oils and waxes (tar) that stick to surfaces, like walls, furniture, clothing and hair. Thirdhand smoke cannot be removed by ventilation. Many of the toxins and carcinogens in smoke linger for days, months and years after the cigarettes are gone. My laboratory is funded by the California Tobacco-Related Disease Research Program to study how humans absorb thirdhand smoke from the environment. My laboratory is also funded by the FDA and the NIH to study the cardiovascular effects of tobacco and nicotine delivery products. I am member of the California Thirdhand Smoke Consortium, the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF Center for Tobacco Control Research and Education. My goals are to understand how smoke causes heart attacks and respiratory disease and to educate society on the true impact that air pollution has on human health.

Education

  • University of Washington    B.S.    1986-1989    Cell and Molecular Biology
  • University of California, San Francisco    Ph.D.    1991-2001    Biomedical Science
  • University of California, San Francisco    Postdoc    2002-2006    Public Health
  • University of California, San Francisco    Postdoc    Feb 2006-Sept 2007    Inhalation Toxicology
     

Professional Experience

  • 1989-1991    
    Research Technician, University of Washington, Department of Zoology
  • 2001
    Title X Intern, Planned Parenthood Golden Gate
  • 2007    
    Assistant Adjunct Professor, UCSF School of Medicine, Division of Occupational and Environmental Medicine
     

Honors & Awards

  • 1991
    National Science Foundation Predoctoral Fellowship

Selected Publications

  1. Xu EG, Richardot WH, Li S, Buruaem L, Wei HH, Dodder NG, Schick SF, Novotny T, Schlenk D, Gersberg RM, Hoh E. Assessing Toxicity and in Vitro Bioactivity of Smoked Cigarette Leachate Using Cell-Based Assays and Chemical Analysis. Chem Res Toxicol. 2019 Aug 19; 32(8):1670-1679.
    View on PubMed
  2. Jaques, PA, Zalay, M, Huang, A, Jee, K, Schick, SF. . Proceedings of the 15th Conference of the International Society of Indoor Air Quality & Climate, Philadelphia, PA, USA July 22 to 27, 2018. Measuring Aerosol Particle Emissions from Cannabis Vaporization and Dabbing. 2019.
    View on PubMed
  3. Pozuelos GL, Kagda MS, Schick S, Girke T, Volz DC, Talbot P. Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome: A Randomized Clinical Trial. JAMA Netw Open. 2019 Jun 05; 2(6):e196362.
    View on PubMed
  4. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 Jun 04; 73(21):2722-2737.
    View on PubMed
  5. Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol. 2019 Apr 01; 316(4):H801-H827.
    View on PubMed
  6. Whitlatch A, Schick S. Thirdhand Smoke at Philip Morris. Nicotine Tob Res. 2018 Jul 20.
    View on PubMed
  7. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40.
    View on PubMed
  8. Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob P, Benowitz N, Destaillats H, Tang X, Xia Y, Jen KY, Gundel LA, Mao JH, Snijders AM. Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice. Clin Sci (Lond). 2018 02 28; 132(4):475-488.
    View on PubMed
  9. Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A. Biomarkers of exposure to new and emerging tobacco delivery products. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L425-L452.
    View on PubMed
  10. Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob P, Benowitz N, Destaillats H, Gundel LA, Mao JH. Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice. Sci Rep. 2017 02 03; 7:41915.
    View on PubMed
  11. Jacob P, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJ, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP. Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chem Res Toxicol. 2017 01 17; 30(1):270-294.
    View on PubMed
  12. Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 07 27; 5(8).
    View on PubMed
  13. Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot P. From the Cover: Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells. Toxicol Sci. 2016 09; 153(1):55-69.
    View on PubMed
  14. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. Corrigendum: Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2016 Apr 13; 6:23849.
    View on PubMed
  15. Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML. Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci. 2016 Jan 01; 2(1):56-63.
    View on PubMed
  16. Bahl V, Weng NJ, Schick SF, Sleiman M, Whitehead J, Ibarra A, Talbot P. Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. Toxicol Sci. 2016 Mar; 150(1):234-46.
    View on PubMed
  17. Bahl V, Shim HJ, Jacob P, Dias K, Schick SF, Talbot P. Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments. Toxicol In Vitro. 2016 Apr; 32:220-31.
    View on PubMed
  18. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2015 Oct 22; 5:15512.
    View on PubMed
  19. Waldo SW, Brenner DA, McCabe JM, De la Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(5):e0126062.
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  20. Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(2):e0118081.
    View on PubMed

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