University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Tara Sigdel, PhD

Tara Sigdel, PhD

Assistant Professor, Department of Surgery, UCSF

Cancer Center Program Memberships

Affiliate Member

Research Summary

My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Education

Tribhuvan University, Nepal, B.Sc., 08/87-07/89, Biology/Chemistry
Tribhuvan University, Nepal, M.Sc., 07/90-08/92, Chemistry
Miami University, Oxford, OH & Stanford University, Ph.D., 08/00-09/05, Biochemistry
Stanford University, Postdoctoral Training, 11/05-06/09, Biomarker Discovery in Organ Transplantation


Professional Experience

  • 1992-1993
    Research Assistant, Research Laboratory for Agricultural Biotechnology and Biochemistry
  • 1993-1994
    Lecturer, Tribhuvan University, Kathmandu, Nepal
  • 1995-2000
    Chemistry Faculty, Chemistry Dept, Budhanilkantha School, Kathmandu, Nepal
  • 1999-2000
    Chair, Chemistry Dept., Budhanilkantha School, Kathmandu, Nepal
  • 2000-2003
    Teaching Associate, Miami University, Oxford, OH
  • 2004-2005
    Graduate Research Assistant, Miami University, Oxford, OH
  • 2005-2009
    Postdoctoral Fellow, Stanford University, Stanford, CA
  • 2009-2011
    Research Associate, Stanford University, Stanford, CA
  • 2012-2014
    Associate Scientist, California Pacific Medical Center, San Francisco, CA
  • 2014-present
    Assistant Professor, University of California San Francisco, San Francisco, CA

Honors & Awards

  • 2007-2008
    Recipient of Deans Fellowship 2007-2008, Stanford University
  • 2008-2009
    Recipient of Pediatric Research Fund – CHRP Award
  • 2008
    Helena Anna Henzl Gabor Award to attend XXII International Congress of The Transplantation Society, Sydney, Australia
  • 2009-2010
    Recipient of Pediatric Research Fund – CHRP Award
  • 2009-2010
    Awarded with Transplant and Tissue Engineering Center of Excellence (COE) grant to work
    as a postdoctoral fellow on the development of a novel non-Invasive urinary proteomic panel for monitoring transplant health.

Selected Publications

  1. Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM. Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies. Front Med (Lausanne). 2019; 6:213.
    View on PubMed
  2. Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM. A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. PLoS One. 2019; 14(7):e0220052.
    View on PubMed
  3. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH. A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer. Cytometry A. 2019 Sep; 95(9):1019-1030.
    View on PubMed
  4. Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing. Nat Commun. 2019 04 23; 10(1):1906.
    View on PubMed
  5. Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM. A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury. J Clin Med. 2019 Apr 12; 8(4).
    View on PubMed
  6. Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM. Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival. J Clin Med. 2019 Feb 13; 8(2).
    View on PubMed
  7. Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, Moshkevich S, Sarwal MM. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR. J Clin Med. 2018 Dec 23; 8(1).
    View on PubMed
  8. Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM. The common rejection module in chronic rejection post lung transplantation. PLoS One. 2018; 13(10):e0205107.
    View on PubMed
  9. Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM. Urinary Virome Perturbations in Kidney Transplantation. Front Med (Lausanne). 2018; 5:72.
    View on PubMed
  10. Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z. Targeted Transcriptional Profiling of Kidney Transplant Biopsies. Kidney Int Rep. 2018 May; 3(3):722-731.
    View on PubMed
  11. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2018; 9:107.
    View on PubMed
  12. Sigdel TK, Sarwal MM. Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. Methods Mol Biol. 2018; 1788:11-21.
    View on PubMed
  13. Towfighi P, Shaw J, Sigdel T. Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics. Methods Mol Biol. 2018; 1788:157-164.
    View on PubMed
  14. Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG, Qian WJ. LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers. Methods Mol Biol. 2018; 1788:145-156.
    View on PubMed
  15. Sigdel TK, Nicora CD, Qian WJ, Sarwal MM. Optimization for Peptide Sample Preparation for Urine Peptidomics. Methods Mol Biol. 2018; 1788:63-72.
    View on PubMed
  16. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2017; 8:1687.
    View on PubMed
  17. Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM. Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection. Front Med (Lausanne). 2017; 4:185.
    View on PubMed
  18. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954.
    View on PubMed
  19. Sigdel TK, Sarwal MM. Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients. Front Med (Lausanne). 2017; 4:80.
    View on PubMed
  20. Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O. Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection. Transplantation. 2017 06; 101(6):1400-1409.
    View on PubMed

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