Research Summary

My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Education

Tribhuvan University, Nepal, B.Sc., 08/87-07/89, Biology/Chemistry
Tribhuvan University, Nepal, M.Sc., 07/90-08/92, Chemistry
Miami University, Oxford, OH & Stanford University, Ph.D., 08/00-09/05, Biochemistry
Stanford University, Postdoctoral Training, 11/05-06/09, Biomarker Discovery in Organ Transplantation

Honors & Awards

  • 2007-2008
    Recipient of Deans Fellowship 2007-2008, Stanford University
  • 2008-2009
    Recipient of Pediatric Research Fund – CHRP Award
  • 2008
    Helena Anna Henzl Gabor Award to attend XXII International Congress of The Transplantation Society, Sydney, Australia
  • 2009-2010
    Recipient of Pediatric Research Fund – CHRP Award
  • 2009-2010
    Awarded with Transplant and Tissue Engineering Center of Excellence (COE) grant to work as a postdoctoral fellow on the development of a novel non-Invasive urinary proteomic panel for monitoring transplant health.

Selected Publications

  1. Swensen AC, He J, Fang AC, Ye Y, Nicora CD, Shi T, Liu AY, Sigdel TK, Sarwal MM, Qian WJ A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.  View on PubMed
  2. Zarinsefat A, Guerra JMA, Sigdel T, Damm I, Sarwal R, Chan-On C, Szabo G, Aguilar-Frasco JL, Ixtlapale-Carmona X, Salinas-Ramos C, Ramirez-Martinez L, Ramirez C, Vilatoba M, Morales Buenrostro LE, Alberu JM, Sarwal MM Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation.  View on PubMed
  3. Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.  View on PubMed
  4. El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobib D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M, Azeloglu EU, Sealfon R, Winfree S, Steck B, He Y, D'Agati VD, Iyengar R, Troyanskaya OG, Barisoni L, Gaut J, Zhang K, Laszik Z, Rovin B, Dagher PC, Sharma K, Sarwal M, Hodgin JB, Alpers CE, Kretzer M, Jain S, The Kidney Precision Medicine Project F A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project.  View on PubMed
  5. Sigdel TK, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG, Sarwal MM The Identification of Novel Potential Injury Mechanisms and Candidate Biomarkers in Renal Allograft Rejection by Quantitative Proteomics.  View on PubMed
  6. Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.  View on PubMed
  7. Pineda S, Sur S, Sigdel T, Nguyen M, Crespo E, Torija A, Meneghini M, Gomà M, Sirota M, Bestard O, Sarwal MM Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection.  View on PubMed
  8. Sigdel TK, Schroeder AW, Yang JYC, Sarwal RD, Liberto JM, Sarwal MM Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.  View on PubMed
  9. Mannon RB, Armstrong B, Stock PG, Mehta AK, Farris AB, Watson N, Morrison Y, Sarwal M, Sigdel T, Bridges N, Robien M, Newell KA, Larsen CP Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.  View on PubMed
  10. Yang JYC, Sarwal RD, Sigdel TK, Damm I, Rosenbaum B, Liberto JM, Chan-On C, Arreola-Guerra JM, Alberu J, Vincenti F, Sarwal MM A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.  View on PubMed
  11. Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.  View on PubMed
  12. Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.  View on PubMed
  13. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.  View on PubMed
  14. Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.  View on PubMed
  15. Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.  View on PubMed
  16. Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.  View on PubMed
  17. Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, Moshkevich S, Sarwal MM Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.  View on PubMed
  18. Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM The common rejection module in chronic rejection post lung transplantation.  View on PubMed
  19. Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM Urinary Virome Perturbations in Kidney Transplantation.  View on PubMed
  20. Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z Targeted Transcriptional Profiling of Kidney Transplant Biopsies.  View on PubMed

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