Research Summary

My research interests are primarily focused on the application of Magnetic Resonance technology to characterize the underlying metabolic dysregulation in pathologies and use them to develop clinically relevant markers for diagnostic and therapeutic purposes. Specifically, I’ve been engrossed with the application of hyperpolarized dissolution dynamic nuclear polarization MRI technique to urologic cancers; renal cell carcinoma, bladder and prostate cancer. Recently I've been exploring the differential metabolism of bacteria to develop specific imaging biomarkers infectious disease.

Education

University of Madras, Chennai, India, B.Engg., Instrumentation and Control Engineering
University of California Davis, CA, Ph.D., BioPhysics

Honors & Awards

  • 2003
    Non resident Tuition Fellowship, Biophysics Graduate Group, UC Davis
  • 2008
    Pfizer Global Research Centers of Excellence award for Delivery
  • 2009
    Individual Performance Award, Pfizer

Selected Publications

  1. Nayak S, Salkever H, Diaz E, Sinha A, Deveshwar N, Hess M, Gibbons M, Sahin S, Rajagopal A, Larson PEZ, Sriram R. Deep Learning-Based Tumor Segmentation of Murine Magnetic Resonance Images of Prostate Cancer Patient-Derived Xenografts. Tomography. 2025 Feb 22; 11(3).  View on PubMed
  2. Bidkar AP, Peter R, Wadhwa A, Bobba KN, Bidlingmaier S, Meher N, Chou J, Greenland N, Dasari C, Naik S, Raveendran A, Basak M, Camara Serrano JA, Steri V, Kogan S, Oskowitz A, He J, Wilson DM, Aggarwal R, Sriram R, VanBrocklin HF, Seo Y, Liu B, Flavell RR. Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy. Clin Cancer Res. 2025 Feb 13.  View on PubMed
  3. Meher N, Bidkar AP, Wadhwa A, Bobba KN, Dhrona S, Dasari C, Mu C, Fong COY, Cámara JA, Ali U, Basak M, Bulkley D, Steri V, Fontaine SD, Zhu J, Oskowitz A, Aggarwal RR, Sriram R, Chou J, Wilson DM, Seo Y, Santi DV, Ashley GW, VanBrocklin HF, Flavell RR. PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer. Mol Cancer Ther. 2025 Jan 02; 24(1):141-151.  View on PubMed
  4. Diaz E, Sriram R, Gordon JW, Sinha A, Liu X, Sahin S, Crane J, Olson MP, Chen HY, Bernard J, Vigneron DB, Wang ZJ, Xu D, Larson PEZ. Data Format Standardization and DICOM Integration for Hyperpolarized 13C MRI. ArXiv. 2024 May 06.  View on PubMed
  5. Diaz E, Sriram R, Gordon JW, Sinha A, Liu X, Sahin SI, Crane JC, Olson MP, Chen HY, Bernard JML, Vigneron DB, Wang ZJ, Xu D, Larson PEZ. Data Format Standardization and DICOM Integration for Hyperpolarized 13C MRI. J Imaging Inform Med. 2024 Oct; 37(5):2627-2634.  View on PubMed
  6. Habowski AN, Budagavi DP, Scherer SD, Aurora AB, Caligiuri G, Flynn WF, Langer EM, Brody JR, Sears RC, Foggetti G, Arnal Estape A, Nguyen DX, Politi KA, Shen X, Hsu DS, Peehl DM, Kurhanewicz J, Sriram R, Suarez M, Xiao S, Du Y, Li XN, Navone NM, Labanca E, Willey CD. Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations. Cancers (Basel). 2024 Jan 29; 16(3).  View on PubMed
  7. Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA. Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease. Magn Reson Med. 2024 Apr; 91(4):1625-1636.  View on PubMed
  8. Hamsah E, Robinson F, Hayati F, Arsat N, Kaur N, Sriram RK, Subramaniam S, Kandasami ND, Lai CK, Abd Karim K. Links between socio-demographic characteristics and body mass index to colorectal cancer in North Borneo, Malaysia: A case-control study. Med J Malaysia. 2023 Dec; 78(7):876-882.  View on PubMed
  9. Yeste J, Azagra M, Ortega MA, Portela A, Matajsz G, Herrero-Gómez A, Kim Y, Sriram R, Kurhanewicz J, Vigneron DB, Marco-Rius I. Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance. Lab Chip. 2023 Nov 21; 23(23):4950-4958.  View on PubMed
  10. Mu C, Liu X, Kim Y, Riselli A, Korenchan DE, Bok RA, Delos Santos R, Sriram R, Qin H, Nguyen H, Gordon JW, Slater J, Larson PEZ, Vigneron DB, Kurhanewicz J, Wilson DM, Flavell RR. Clinically Translatable Hyperpolarized 13C Bicarbonate pH Imaging Method for Use in Prostate Cancer. ACS Sens. 2023 11 24; 8(11):4042-4054.  View on PubMed
  11. Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, Fraser JS, Wilson DM. Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo. J Am Chem Soc. 2023 08 16; 145(32):17632-17642.  View on PubMed
  12. Chetta P, Sriram R, Zadra G. Lactate as Key Metabolite in Prostate Cancer Progression: What Are the Clinical Implications? Cancers (Basel). 2023 Jul 03; 15(13).  View on PubMed
  13. Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, Fraser JS, Wilson DM. Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [ 18 F]FDG yield potent sensors of living bacteria in vivo. bioRxiv. 2023 May 20.  View on PubMed
  14. Moore SM, Quirk JD, Lassiter AW, Laforest R, Ayers GD, Badea CT, Fedorov AY, Kinahan PE, Holbrook M, Larson PEZ, Sriram R, Chenevert TL, Malyarenko D, Kurhanewicz J, Houghton AM, Ross BD, Pickup S, Gee JC, Zhou R, Gammon ST, Manning HC, Roudi R, Daldrup-Link HE, Lewis MT, Rubin DL, Yankeelov TE, Shoghi KI. Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging. Tomography. 2023 05 11; 9(3):995-1009.  View on PubMed
  15. Gammon ST, Cohen AS, Lehnert AL, Sullivan DC, Malyarenko D, Manning HC, Hormuth DA, Daldrup-Link HE, An H, Quirk JD, Shoghi K, Pagel MD, Kinahan PE, Miyaoka RS, Houghton AM, Lewis MT, Larson P, Sriram R, Blocker SJ, Pickup S, Badea A, Badea CT, Yankeelov TE, Chenevert TL. An Online Repository for Pre-Clinical Imaging Protocols (PIPs). Tomography. 2023 03 27; 9(2):750-758.  View on PubMed
  16. Sahin SI, Ji X, Agarwal S, Sinha A, Mali I, Gordon JW, Mattingly M, Subramaniam S, Kurhanewicz J, Larson PEZ, Sriram R. Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized 13C-Pyruvate MRI. Tomography. 2023 03 27; 9(2):736-749.  View on PubMed
  17. Peehl DM, Badea CT, Chenevert TL, Daldrup-Link HE, Ding L, Dobrolecki LE, Houghton AM, Kinahan PE, Kurhanewicz J, Lewis MT, Li S, Luker GD, Ma CX, Manning HC, Mowery YM, O'Dwyer PJ, Pautler RG, Rosen MA, Roudi R, Ross BD, Shoghi KI, Sriram R, Talpaz M, Wahl RL, Zhou R. Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials. Tomography. 2023 03 16; 9(2):657-680.  View on PubMed
  18. Malyarenko D, Amouzandeh G, Pickup S, Zhou R, Manning HC, Gammon ST, Shoghi KI, Quirk JD, Sriram R, Larson P, Lewis MT, Pautler RG, Kinahan PE, Muzi M, Chenevert TL. Evaluation of Apparent Diffusion Coefficient Repeatability and Reproducibility for Preclinical MRIs Using Standardized Procedures and a Diffusion-Weighted Imaging Phantom. Tomography. 2023 02 07; 9(1):375-386.  View on PubMed
  19. Agudelo JP, Upadhyay D, Zhang D, Zhao H, Nolley R, Sun J, Agarwal S, Bok RA, Vigneron DB, Brooks JD, Kurhanewicz J, Peehl DM, Sriram R. Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma. Metabolites. 2022 Nov 15; 12(11).  View on PubMed
  20. Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, Aggarwal R, Evans MJ. CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease. Clin Cancer Res. 2022 07 15; 28(14):3066-3075.  View on PubMed

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