University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Elliot Stieglitz, MD

Elliot Stieglitz, MD

Assistant Professor, Pediatric Hematology/Oncology, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Juvenile myelomonocytic leukemia (JMML) is a blood cancer that affects young children and is often difficult to diagnose and treat. Currently available therapies cure only half of patients, with some children experiencing an aggressive disease course while a rare group get better with very little treatment. We have now shown that presence of secondary mutations via deep sequencing or droplet digital PCR predicts a poor outcome. We have most recently show that DNA methylation profiling can predict both good and poor responders at diagnosis.

We are also running a clinical trial through the Children's Oncology Group for patients with relapsed and refractory JMML. This trial will test the safety and efficacy of the oral MEK inhibitor, trametinib. This trial is based on extensive pre-clinical testing and a strong genomic rationale. This trial marks an important step towards more effectively treating patients with Ras driven leukemia using targeted agents.

Education

Yeshiva University, New York, B.A., 06/03, Biology
Stony Brook School of Medicine, New York, M.D., 06/08, Medicine
NYPH - Weill Cornell Medical Center, New York, Residency, 06/11, Pediatrics
University of California, San Francisco, Fellowship, 07/14, Pediatric Heme/Onc


Professional Experience

  • 2003-2004
    Certified Public High School Chemistry Teacher, New York, NY
  • 2008-2011
    Pediatric Resident, New York Presbyterian Hospital - Weill Cornell, New York, NY
  • 2011-2014
    Pediatric Hematology/Oncology Fellow, University of California San Francisco, CA
  • 2014-2015
    Clinical Instructor, Pediatric Hematology/Oncology, UCSF, San Francisco, CA
  • 2015-2017
    Adjunct Professor, PediatricHematology/Oncology, UCSF, SanFrancisco, CA
  • 2017-present
    Assistant Professor, Pediatric Hematology/Oncology, UCSF, SanFrancisco, CA

Honors & Awards

  • 2008
    Barry S. Coller International Research Award, Stony Brook University
  • 2008
    Global Public Health Intern, Naval Medical Research Center, Peru
  • 2012-2013
    Trainee on NIH T32 Grant, “Research Training in Childhood Cancer”
  • 2013
    AACR “Molecular Biology in Clinical Oncology” workshop, Aspen, CO
  • 2014-2016
    St. Baldrick’s Foundation Fellowship Award
  • 2014
    ASH Annual Meeting Abstract Achievement Award, San Francisco, CA
  • 2014
    JMML Symposium Abstract Award San Francisco, CA
  • 2015-2017
    NIH Extramural Loan Repayment Program Award for Pediatric Research
  • 2015-2017
    Alex’s Lemonade Stand Foundation, Young Investigator Award
  • 2015
    Northwestern Mutual Foundation Research Award
  • 2015
    SIOP Young Investigator Award, Cape Town, South Africa
  • 2016
    ASH/EHA Translational Training in Hematology Program, Milan/Copenhagen/San Diego
  • 2016
    American Cancer Society , Individual Research Award
  • 2016-2018
    Rally Foundation for Childhood Cancer, Research Award
  • 2017-2021
    NIH K08 Award, National Heart Lung Blood Institute

Selected Publications

  1. Maximilian Schoenung,Elliot Stieglitz,Hideki Muramatsu,Norihiro Murakami,Mark Hartmann,Manuel Wiesenfarth,Yusuke Okuno,Adam B. Olshen,Christoph Plass,Mignon L. Loh,Charlotte Niemeyer,Christian Flotho,Daniel B. Lipka. DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia: An International Collaborative Analysis and Development of a Common Diagnostic Platform. . 2018 Nov 29; 132(Supplement 1):3093-3093.
    View on PubMed
  2. Adam J de Smith,Geneviève Lavoie,Kyle M Walsh,Sumeet Aujla,Erica Evans,Helen M Hansen,Ivan Smirnov,Alice Y Kang,Martin Zenker,John J Ceremsak,Elliot Stieglitz,Roberta McKean-Cowdin,Catherine Metayer,Philippe P Roux,Joseph L Wiemels. Germline GAB2 Mutations in Childhood Acute Lymphoblastic Leukemia. . 2018 Nov 29; 132(Supplement 1):388-388.
    View on PubMed
  3. Andrew E. Place,Traci M. Blonquist,Elliot Stieglitz,Todd M Cooper,Lia Gore,Richard Aplenc,Mignon L. Loh,Melinda Pauly,Rachel E. Rau,Michael J. Burke,Julia Etchin,A. Thomas Look,Maria Luisa Sulis,Lewis B. Silverman. Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia. . 2018 Nov 29; 132(Supplement 1):1405-1405.
    View on PubMed
  4. Elisa Dorantes-Acosta,Hui Huang,Sara P. Garcia,Elliot Stieglitz,Mignon Loh,Guo-Cheng Yuan,Alan B. Cantor. Abstract 26: RUNX1 as a transcriptional target of activated Shp2 (PTPN11) in juvenile myelomonocytic leukemia. . 2017 Dec 15; 26-26.
    View on PubMed
  5. Alan Cantor,Elisa Dorantes-Costa,Hui Huang,Sara Garcia,Elliot Stieglitz,Mignon Loh,Guo-Cheng Yuan. Dysregulation of the transcription factor runx1 in juvenile myelomonocytic leukemia. . 2017 Sep 1; 53:s51.
    View on PubMed
  6. Elisa Dorantes Acosta,Hui Huang,Sara P. Garcia,Elliot Stieglitz,Mignon L. Loh,G C Yuan,Alan B. Cantor. RUNX1 Is a Candidate Transcriptional Effector in Juvenile Myelomonocytic Leukemia. . 2016 Dec 2; 128(22):2699-2699.
    View on PubMed
  7. Alexandra S Whale,Alison S Devonshire,George Karlin-Neumann,Jack Regan,Leanne Javier,Simon Cowen,Ana Fernandez-Gonzalez,Gerwyn M Jones,Nicholas Redshaw,Julia Beck,Andreas W Berger,Valerie Combaret,Nina Dahl Kjersgaard,Lisa Davis,Frederic Fina,Tim Forshew,Rikke Fredslund Andersen,Silvia Galbiati,Alvaro Gonzalez Hernandez,Charles Haynes,Filip Janku,Roger Lacave,Justin Lee,Vilas Mistry,Alexandra Pender,Anne Pradines,Charlotte Proudhon,Lao Saal,Elliot Stieglitz,Bryan Ulrich,Carole A Foy,Helen Parkes,Svilen Tzonev,Jim Huggett. AN INTERNATIONAL INTER-LABORATORY DIGITAL PCR STUDY DEMONSTRATES HIGH REPRODUCIBILITY FOR THE MEASUREMENT OF A RARE SEQUENCE VARIANT. . 2016 Sep 28; 077917.
    View on PubMed
  8. Elliot Stieglitz,Camille B Troup,Laura C Gelston,Eric D Chow,Kristie B Yu,Jon Akutagawa,Amaro N Taylor-Weiner,Y. Lucy Liu,Peter D Emanuel,Benjamin S Braun,Robert B. Gerbing,Todd A. Alonzo,Mignon L. Loh. Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia. . 2014 Dec 6; 124(21):410-410.
    View on PubMed
  9. Elliot Stieglitz,Y. Lucy Liu,Peter D. Emanuel,Robert P. Castleberry,Todd Michael Cooper,Kevin Shannon,Mignon L. Loh. Mutations In GATA2 Are Rare In Juvenile Myelomonocytic Leukemia. . 2013 Nov 15; 122(21):1526-1526.
    View on PubMed

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