University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Christian Vaisse, MD, PhD

Christian Vaisse, MD, PhD

Associate Professor, Department of Medicine (Diabetes Center), UCSF

Cancer Center Program Memberships

Affiliate Member

Education

University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology


Professional Experience

  • 1991-1995
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1995-1997
    Post-Doctoral Fellow, Rockefeller University, New-York
  • 1997
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1997-1999
    Senior Scientist (INSERM Tenure) Pasteur institute and Attending Physician Department of Internal medicine and Nutrition at Hospital Hotel-Dieu, Paris
  • 1999-present
    Assistant Professor in Residence, Department of Medicine and Diabetes Research Center, University of California San Francisco

Honors & Awards

  • 1995
    ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
  • 1996
    Philippe Foundation Post-Doctoral Research Award
  • 1998
    INSERM-CR1 tenure
  • 1999-00
    Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
  • 2000
    American Diabetes Association-Career Development Award
  • 2000
    North American Association for the Study of Obesity-Pilot Study Award
  • 2002
    Greenberg Young Investigator Award in Cardiovascular Genetics

Selected Publications

  1. Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA. Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies. Am J Clin Nutr. 2019 Sep 25.
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  2. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2019 Apr; 1(4):475-484.
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  3. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science. 2019 01 18; 363(6424).
    View on PubMed
  4. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 02; 50(2):180-185.
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  5. Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7).
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  6. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271.
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  7. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. The Association of Serum Leptin with Mortality in Older Adults. PLoS One. 2015; 10(10):e0140763.
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  8. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014; 9(5):e96805.
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  9. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17.
    View on PubMed
  10. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 01; 23(7):1700-8.
    View on PubMed
  11. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Int J Obes (Lond). 2014 Jan; 38(1):148-51.
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  12. Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nat Chem Biol. 2012 Aug; 8(8):725-30.
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  13. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011 Jul; 21(7):930-4.
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  14. Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring). 2011 Dec; 19(12):2394-2403.
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  15. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93.
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  16. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. Bariatric surgery in a patient with complete MC4R deficiency. Int J Obes (Lond). 2011 Mar; 35(3):457-61.
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  17. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25.
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  18. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009 Sep; 23(9):3059-69.
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  19. Calton MA, Vaisse C. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Med. 2009 Mar 11; 1(3):31.
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  20. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93.
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