Research Funding

  • July 1, 2020 - June 30, 2025 - From Obesity GWAS to therapeutic targets, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK124769
  • February 15, 2002 - August 31, 2020 - The Melanocortin-4 Receptor in Human Obesity, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: R56DK060540
  • August 1, 2015 - July 31, 2020 - UCSF Nutrition Obesity Research Center, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK098722
  • June 1, 2016 - April 30, 2020 - Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK106404

Education

University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology

Honors & Awards

  • 1995
    ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
  • 1996
    Philippe Foundation Post-Doctoral Research Award
  • 1998
    INSERM-CR1 tenure
  • 1999-00
    Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
  • 2000
    American Diabetes Association-Career Development Award
  • 2000
    North American Association for the Study of Obesity-Pilot Study Award
  • 2002
    Greenberg Young Investigator Award in Cardiovascular Genetics

Selected Publications

  1. Adelaide A Bernard, Irene Ojeda Naharros, Florence Bourgain Guglielmetti, Xinyu Yue, Christian Vaisse OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R.  View on PubMed
  2. Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies.  View on PubMed
  3. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.  View on PubMed
  4. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.  View on PubMed
  5. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.  View on PubMed
  6. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.  View on PubMed
  7. Vaisse C, Reiter JF, Berbari NF Cilia and Obesity.  View on PubMed
  8. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.  View on PubMed
  9. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR The Association of Serum Leptin with Mortality in Older Adults.  View on PubMed
  10. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.  View on PubMed
  11. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.  View on PubMed
  12. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N Functional characterization of SIM1-associated enhancers.  View on PubMed
  13. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus.  View on PubMed
  14. Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.  View on PubMed
  15. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations.  View on PubMed
  16. Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC Replication and extension of association between common genetic variants in SIM1 and human adiposity.  View on PubMed
  17. Ivy R. Aslan, Sayali A. Ranadive, Christian Vaisse Monogenic Disorders Within the Energy Balance Pathway.  View on PubMed
  18. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.  View on PubMed
  19. M.M. Swarbrick, D.S. Evans, M.I.V. Ascencio, H. Favre, S.-H. Wu, O.T. Njajou, R. Li, J.M. Zmuda, I. Miljkovic, T.B. Harris, P.-Y. Kwok, C. Vaisse, W.-C. Hsueh Systematic examination of the SIM1 gene region: Replication and extension of association between common genetic variants and adiposity.  View on PubMed
  20. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C Bariatric surgery in a patient with complete MC4R deficiency.  View on PubMed

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