Research Funding

  • June 1, 2016 - July 31, 2026 - Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK106404
  • February 15, 2002 - August 31, 2025 - The Melanocortin-4 Receptor in Human Obesity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK060540
  • August 1, 2015 - July 31, 2025 - UCSF Nutrition Obesity Research Center , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P30DK098722
  • July 1, 2020 - June 30, 2025 - From Obesity GWAS to therapeutic targets , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK124769
  • September 1, 2002 - March 31, 2021 - Diabetes Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30DK063720
  • February 15, 2002 - August 31, 2020 - The Melanocortin-4 Receptor in Human Obesity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56DK060540
  • May 1, 2012 - March 31, 2016 - Identification & functional characterization of SIM1 obesity-associated variants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK090382
  • September 15, 2005 - July 31, 2010 - Role of Pro-opiomelanocortin mutations in human obesity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK068152
  • December 1, 1974 - March 31, 2009 - General Clinical Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR000079
  • October 1, 1974 - November 30, 2007 - General Clinical Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR000083
  • December 1, 1981 - March 31, 2007 - PEDIATRIC CLINICAL RESEARCH CENTER , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR001271

Education

University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology

Honors & Awards

  • 1995
    ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
  • 1996
    Philippe Foundation Post-Doctoral Research Award
  • 1998
    INSERM-CR1 tenure
  • 1999-00
    Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
  • 2000
    American Diabetes Association-Career Development Award
  • 2000
    North American Association for the Study of Obesity-Pilot Study Award
  • 2002
    Greenberg Young Investigator Award in Cardiovascular Genetics

Selected Publications

  1. Ojeda-Naharros I, Das T, Castro RA, Bazan JF, Vaisse C, Nachury MV Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia.  View on PubMed
  2. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Author Correction: Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2024 Mar; 6(3):598.  View on PubMed
  3. Brewer KK, Brewer KM, Terry TT, Caspary T, Vaisse C, Berbari NF Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.  View on PubMed
  4. Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW Identification of AgRP cells in the murine hindbrain that drive feeding.  View on PubMed
  5. Terry TT, Gigante ED, Alexandre CM, Brewer KM, Engle SE, Yue X, Berbari NF, Vaisse C, Caspary T. Ciliary ARL13B prevents obesity in mice. bioRxiv. 2023 Aug 04.  View on PubMed
  6. TOMAS P. BACHOR, KUSH ATTAL, EIRINI VAGENA, FRANCOIS MIFSUD, VIANA PHAM, MARTIN VALDEARCOS-CONTRERAS, CHRISTIAN VAISSE, ALLISON XU 1522-P: Identification of AgRP Cells in the Murine Hindbrain That Drive Feeding.  View on PubMed
  7. Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF. Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain. eNeuro. 2023 03; 10(3).  View on PubMed
  8. Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. JCI Insight. 2023 01 24; 8(2).  View on PubMed
  9. Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Sci Adv. 2022 Mar 11; 8(10):eabj2917.  View on PubMed
  10. Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 05 03; 131(9).  View on PubMed
  11. Adelaide A Bernard, Irene Ojeda Naharros, Florence Bourgain Guglielmetti, Xinyu Yue, Christian Vaisse. OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R. Journal of the Endocrine Society. 2020 May 8; 4(Supplement_1):or04-01-.  View on PubMed
  12. Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA. Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies. Am J Clin Nutr. 2019 12 01; 110(6):1316-1326.  View on PubMed
  13. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. . 2019 Sep 12.  View on PubMed
  14. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2019 04; 1(4):475-484.  View on PubMed
  15. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science. 2019 01 18; 363(6424).  View on PubMed
  16. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 02; 50(2):180-185.  View on PubMed
  17. Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7).  View on PubMed
  18. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271.  View on PubMed
  19. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. The Association of Serum Leptin with Mortality in Older Adults. PLoS One. 2015; 10(10):e0140763.  View on PubMed
  20. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014; 9(5):e96805.  View on PubMed

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