University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Arun P. Wiita, MD, PhD

Arun P. Wiita, MD, PhD

Health Sciences Clinical Instructor, Dept. of Laboratory Medicine, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

My research laboratory spans a number of areas within genomics, proteomics, and hematologic malignancies. One major area of research involves the use of targeted, quantitative proteomics to answer important biological questions in myeloma and B-cell leukemia. We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

Education

2002, Princeton University, Princeton, NJ, A.B., Chemistry
2008, Columbia University, New York, NY, Ph.D, Neurobiology/Biophysics
2009, Columbia University, New York, NY, M.D., Medicine
2012, University of California, San Francisco, CA, Residency, Laboratory Medicine
2014, University of California, San Francisco, CA, Post-Doc, Pharmaceutical Chemistry


Professional Experience

  • 2007
    Graduate Student Fellow, Columbia U. Science & Technology Venture
  • 2008-2009
    Co-founder, MedVolution Systems, Inc. (clinical decision support software)
  • 2009-2012
    Resident, Dept. of Laboratory Medicine, UCSF
  • 2012-2014
    Post-doctoral Scholar, Wells Lab, Dept. of Pharmaceutical Chemistry, UCSF
  • 2014-present
    HS Clinical Instructor, Dept. of Laboratory Medicine, UCSF

Honors & Awards

  • 2008
    Winner, Wharton Venture Award, team “Bayesian Diagnosis Pro”, U. Penn.
  • 2008
    Dean’s Award for Excellence in Research, Columbia U. College of P&S (best Ph.D. thesis prize)
  • 2010, 2013
    Paul Strandjord Young Investigator Award, Academy of Clinical & Lab. Physicians and Scientists
  • 2010
    Laurence J. Marton Award for Excellence in Research, Dept. Lab. Med., UCSF
  • 2010
    Julius Krevans Award for Clinical Excellence, San Francisco General Hospital/UCSF
  • 2012
    NIH Ruth F. Kirschstein F32 Post-doctoral Fellowship (declined)
  • 2012
    Jane Coffin Childs Fund Post-doctoral Fellowship (declined)
  • 2012-15
    Damon Runyon Cancer Research Foundation Post-doctoral Fellowship

Selected Publications

  1. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 Jan 13.
    View on PubMed
  2. Ha TK, Mardy AH, Beleford D, Spanier A, Wayman BV, Penon-Portmann M, Wiita AP, Shieh JT. X-linked duplication copy number variation in a familial overgrowth condition. Am J Med Genet C Semin Med Genet. 2019 Nov 25.
    View on PubMed
  3. Jaewoong Lee, Gang Xiao, Kadriye Nehir Nehir Cosgun, Huimin Geng, Ning Ma, Lai N Chan, Kohei Kume, Matthew Nix, Zhengshan Chen, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Michael S. Diamond, Jae U Jung, Nagarajan Vaidehi, Markus Müschen. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis. Blood. 2019 Nov 13; 134(Supplement_1):2782-2782.
    View on PubMed
  4. Matthew Nix, Yu-Hsiu T. Lin, Huimin Geng, Makeba Marcoulis, Paul Phojanakong, Donghui Wang, Veronica Steri, Jeffrey Whitman, Sagar Bapat, Elliot Stieglitz, Anne Deucher, Kristie L White, Byron C Hann, Arun P. Wiita. In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies. Blood. 2019 Nov 13; 134(Supplement_1):1337-1337.
    View on PubMed
  5. Ian Ferguson, Yu-Hsiu T. Lin, Sami Tuomivaara, Jeffrey L. Wolf, Thomas G. Martin, Sandy W. Wong, Nina D. Shah, Christoph Driessen, Brian G. Van Ness, Arun P. Wiita. Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology. Blood. 2019 Nov 13; 134(Supplement_1):1803-1803.
    View on PubMed
  6. Lai N Chan, Mark A. Murakami, Rebecca Caesar, Christian Hurtz, Kohei Kume, Teresa Sadras, Seyedmehdi Shojaee, Petri Pölönen, Amol Ugale, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Merja Heinäniemi, Olli Lohi, Arun P. Wiita, Shai Izraeli, David M Weinstock, Markus Müschen. Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation. Blood. 2019 Nov 13; 134(Supplement_1):3944-3944.
    View on PubMed
  7. Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP. Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood Adv. 2019 Nov 12; 3(21):3214-3227.
    View on PubMed
  8. Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2019 Oct 08.
    View on PubMed
  9. Priya Choudhry, Margarette Mariano, Huimin Geng, Arun Wiita. DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e144-e145.
    View on PubMed
  10. Vishesh Sarin, Katharine Yu, Marina Sirota, Arun Wiita. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e76.
    View on PubMed
  11. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26):13026-13035.
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  12. Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019 May/Jun; 11(4):639-652.
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  13. Spector JD, Wiita AP. ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains. J Hum Genet. 2019 May; 64(5):437-443.
    View on PubMed
  14. Anne H. Mardy, Teresa N. Sparks, Arun P. Wiita, Kathryn Drexler, Brette V. Wayman, Allan Nadel, Mary E. Norton. 880: Variants of uncertain significance in prenatal microarrays. American Journal of Obstetrics and Gynecology. 2019 Jan 1; 220(1):s572-s573.
    View on PubMed
  15. Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001. Oncotarget. 2018 Dec 28; 9(102):37700-37714.
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  16. Priya Choudhry, Margarette C. Mariano, Arun P Wiita. DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):5618-5618.
    View on PubMed
  17. Jae-Woong Lee, Huimin Geng, Derek S Dinson, Gang Xiao, Kadriye Nehir Cosgun, Lai N Chan, Zhengshan Chen, Michael Farzan, Jae U Jung, Arun P Wiita, Markus Muschen. IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation. Blood. 2018 Nov 29; 132(Supplement 1):552-552.
    View on PubMed
  18. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926.
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  19. Yu-Hsiu T. Lin, Gergory P. Way, Margarette C. Mariano, Makeba Marcoulis, Ian Ferguson, Casey S. Greene, Arun P Wiita. Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects. Blood. 2018 Nov 29; 132(Supplement 1):469-469.
    View on PubMed
  20. Ian Ferguson, Christine Lam, Margarette C. Mariano, Donghui Wang, Paul Phojanakong, Sami Toumivaara, Hao Shao, Byron C Hann, Jason Gestwicki, Arun P Wiita. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):3212-3212.
    View on PubMed

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