University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Arun P. Wiita, MD, PhD

Arun P. Wiita, MD, PhD

Health Sciences Clinical Instructor, Dept. of Laboratory Medicine, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

My research laboratory spans a number of areas within genomics, proteomics, and hematologic malignancies. One major area of research involves the use of targeted, quantitative proteomics to answer important biological questions in myeloma and B-cell leukemia. We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

Education

2002, Princeton University, Princeton, NJ, A.B., Chemistry
2008, Columbia University, New York, NY, Ph.D, Neurobiology/Biophysics
2009, Columbia University, New York, NY, M.D., Medicine
2012, University of California, San Francisco, CA, Residency, Laboratory Medicine
2014, University of California, San Francisco, CA, Post-Doc, Pharmaceutical Chemistry


Professional Experience

  • 2007
    Graduate Student Fellow, Columbia U. Science & Technology Venture
  • 2008-2009
    Co-founder, MedVolution Systems, Inc. (clinical decision support software)
  • 2009-2012
    Resident, Dept. of Laboratory Medicine, UCSF
  • 2012-2014
    Post-doctoral Scholar, Wells Lab, Dept. of Pharmaceutical Chemistry, UCSF
  • 2014-present
    HS Clinical Instructor, Dept. of Laboratory Medicine, UCSF

Honors & Awards

  • 2008
    Winner, Wharton Venture Award, team “Bayesian Diagnosis Pro”, U. Penn.
  • 2008
    Dean’s Award for Excellence in Research, Columbia U. College of P&S (best Ph.D. thesis prize)
  • 2010, 2013
    Paul Strandjord Young Investigator Award, Academy of Clinical & Lab. Physicians and Scientists
  • 2010
    Laurence J. Marton Award for Excellence in Research, Dept. Lab. Med., UCSF
  • 2010
    Julius Krevans Award for Clinical Excellence, San Francisco General Hospital/UCSF
  • 2012
    NIH Ruth F. Kirschstein F32 Post-doctoral Fellowship (declined)
  • 2012
    Jane Coffin Childs Fund Post-doctoral Fellowship (declined)
  • 2012-15
    Damon Runyon Cancer Research Foundation Post-doctoral Fellowship

Selected Publications