David A. Quigley, PhD
Felix Feng Endowed Professor
Assistant Professor, Dept. of Urology; Dept. of Epidemiology & Biostatistics, UCSF
Felix Feng Endowed Professor
Assistant Professor, Dept. of Urology; Dept. of Epidemiology & Biostatistics, UCSF
Our lab studies how prostate tumors develop resistance to targeted therapy. We study patient tumors directly to discover how genomic and epigenomic alterations acquired by the tumor affect patient outcomes. This knowledge can help us to develop novel therapies and identify predictive and prognostic biomarkers. Recent projects, in collaboration with physicians and experimental biologists, have used large-scale genome sequencing to identify non-coding DNA structural variants and epigenetic changes associated with therapy resistance in advanced prostate cancer (Lundberg et al. Cancer Research 2023; Zhang et al. Nature Cell Biology 2024; Zhao et al Nature Genetics 2024). Dr. Quigley's research receives support from the National Institutes of Health, the United States Department of Defense, the Prostate Cancer Foundation and the Benioff Initiative for Prostate Cancer Research.
Carleton College, BA, 1998, Computer Science
Columbia University, MA, 2006, Biomedical Informatics
University of Oslo, PhD, 2014, Genetics