Research Funding

  • August 4, 2023 - July 31, 2028 - A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer , Principal Investigator . Sponsor: NIH/NCI, Sponsor Award ID: K01CA279498
  • July 1, 2023 - June 30, 2028 - The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer Outcomes , Co-Investigator . Sponsor: NIH/NCI, Sponsor Award ID: P01CA210961

Education

PhD, 12/2016 - Comparative Biochemistry, University of California, Berkeley
MS, 06/2010 - Bioengineering, California Institute of Technology
BA, 12/2001 - Integrative Biology, University of California, Berkeley

Honors & Awards

  • NCI K01 Mentored Research Scientist Development Award to Promote Diversity, National Cancer Institute (NCI), 2023-2028
  • Butler-Williams Scholar Program, National Institute on Aging (NIA), 2021
  • American Association for Cancer Research (AACR) Associate Award Merit Recipient, San Antonio Breast Cancer Symposium (SABCS), 2019
  • Young Investigator Award, Society for Immunotherapy of Cancer (SITC), 2019
  • NIH T32 Cancer Metabolism Training Grant Postdoctoral Fellowship, Beckman Research Institute, City of Hope Comprehensive Cancer Center, 2018-2020
  • NIH T32 Stem Cell Engineering Training Grant Graduate Fellowship, Berkeley Stem Cell Center, University of California, Berkeley, 2012-2014
  • Chancellor’s Fellowship for Graduate Research, University of California, Berkeley, 2011-2015

Selected Publications

  1. Sayaman RW, Miyano M, Carlson EG, Senapati P, Zirbes A, Shalabi SF, Todhunter ME, Seewaldt VE, Neuhausen SL, Stampfer MR, Schones DE, LaBarge M. Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility. Elife. 2024 Nov 15; 13.  View on PubMed
  2. Del Toro K, Sayaman R, Thi K, Licon-Munoz Y, Hines WC. Transcriptomic analysis of the 12 major human breast cell types reveals mechanisms of cell and tissue function. PLoS Biol. 2024 Nov; 22(11):e3002820.  View on PubMed
  3. Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Shen Y, Salaberry PJ, Zakroui O, Schwarzer C, Scapozza A, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't Veer L, Schor IE, Muñoz DP. Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 + cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype. bioRxiv. 2024 Sep 25.  View on PubMed
  4. Thi K, Del Toro K, Licon-Munoz Y, Sayaman RW, Hines WC. Comprehensive identification, isolation, and culture of human breast cell types. J Biol Chem. 2024 Oct; 300(10):107637.  View on PubMed
  5. Magbanua MJM, Ahmed Z, Sayaman RW, Brown Swigart L, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Perlmutter J, Pohlmann P, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ. Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy. Clin Cancer Res. 2024 Jun 03; 30(11):2444-2451.  View on PubMed
  6. Senapati P, Miyano M, Sayaman RW, Basam M, Leung A, LaBarge MA, Schones DE. Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells. Genome Res. 2023 08; 33(8):1229-1241.  View on PubMed
  7. Roelands J, Kuppen PJK, Ahmed EI, Mall R, Masoodi T, Singh P, Monaco G, Raynaud C, de Miranda NFCC, Ferraro L, Carneiro-Lobo TC, Syed N, Rawat A, Awad A, Decock J, Mifsud W, Miller LD, Sherif S, Mohamed MG, Rinchai D, Van den Eynde M, Sayaman RW, Ziv E, Bertucci F, Petkar MA, Lorenz S, Mathew LS, Wang K, Murugesan S, Chaussabel D, Vahrmeijer AL, Wang E, Ceccarelli A, Fakhro KA, Zoppoli G, Ballestrero A, Tollenaar RAEM, Marincola FM, Galon J, Khodor SA, Ceccarelli M, Hendrickx W, Bedognetti D. An integrated tumor, immune and microbiome atlas of colon cancer. Nat Med. 2023 05; 29(5):1273-1286.  View on PubMed
  8. Magbanua MJM, Brown Swigart L, Ahmed Z, Sayaman RW, Renner D, Kalashnikova E, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Asare S, Liu MC, Albain K, Chien AJ, Forero-Torres A, Isaacs C, Nanda R, Tripathy D, Rodriguez A, Sethi H, Aleshin A, Rabinowitz M, Perlmutter J, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ. Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy. Cancer Cell. 2023 06 12; 41(6):1091-1102.e4.  View on PubMed
  9. Sayaman RW, Saad M, Heimann C, Hu D, Kunji K, Roelands J, Wolf DM, Huntsman S, Ceccarelli M, Thorsson V, Ziv E, Bedognetti D. Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors. STAR Protoc. 2022 12 16; 3(4):101809.  View on PubMed
  10. Chambwe N, Sayaman RW, Hu D, Huntsman S, Cancer Genome Analysis Network, Kemal A, Caesar-Johnson S, Zenklusen JC, Ziv E, Beroukhim R, Cherniack AD. Analysis of germline-driven ancestry-associated gene expression in cancers. STAR Protoc. 2022 09 16; 3(3):101586.  View on PubMed
  11. Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ. Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies. Cancer Cell. 2022 06 13; 40(6):609-623.e6.  View on PubMed
  12. Shalabi SF, Miyano M, Sayaman RW, Lopez JC, Jokela TA, Todhunter ME, Hinz S, Garbe JC, Stampfer MR, Kessenbrock K, Seewaldt VE, LaBarge MA. Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations. Nat Aging. 2021 09; 1(9):838-849.  View on PubMed
  13. Hinz S, Manousopoulou A, Miyano M, Sayaman RW, Aguilera KY, Todhunter ME, Lopez JC, Sohn LL, Wang LD, LaBarge MA. Deep proteome profiling of human mammary epithelia at lineage and age resolution. iScience. 2021 Sep 24; 24(9):103026.  View on PubMed
  14. Zirbes A, Joseph J, Lopez JC, Sayaman RW, Basam M, Seewaldt VL, LaBarge MA. Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression. J Mammary Gland Biol Neoplasia. 2021 09; 26(3):247-261.  View on PubMed
  15. Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA. Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation. Cancer Prev Res (Phila). 2021 08; 14(8):779-794.  View on PubMed
  16. Todhunter ME, Miyano M, Moolamalla DS, Filippov A, Sayaman RW, LaBarge MA. Volume-constrained microcontainers enable myoepithelial functional differentiation in highly parallel mammary organoid culture. iScience. 2021 Apr 23; 24(4):102253.  View on PubMed
  17. Sayaman RW, Miyano M, Senapati P, Shalabi S, Zirbes A, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA. Epigenetic changes with age primes mammary luminal epithelia for cancer initiation. bioRxiv. 2021.  View on PubMed
  18. Sayaman RW, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, Porta-Pardo E, Mokrab Y, Farshidfar F, Kirchhoff T, Sweis RF, Bathe OF, Heimann C, Campbell MJ, Stretch C, Huntsman S, Graff RE, Syed N, Radvanyi L, Shelley S, Wolf D, Marincola FM, Ceccarelli M, Galon J, Ziv E, Bedognetti D. Germline genetic contribution to the immune landscape of cancer. Immunity. 2021 02 09; 54(2):367-386.e8.  View on PubMed
  19. Roelands J, Mall R, Almeer H, Thomas R, Mohamed MG, Bedri S, Al-Bader SB, Junejo K, Ziv E, Sayaman RW, Kuppen PJK, Bedognetti D, Hendrickx W, Decock J. Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry. NPJ Breast Cancer. 2021 Feb 08; 7(1):10.  View on PubMed
  20. Porta-Pardo E, Sayaman RW, Ziv E, Valencia A. The landscape of interactions between cancer polygenic risk scores and somatic alterations in cancer cells. bioRxiv. 2020.  View on PubMed

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