Research Summary

CLINICAL INTERESTS: Dr. Nelson B. Schiller is a cardiologist who specializes in the use of echocardiography in the diagnosis and treatment of heart disease. He is the founder of the UCSF Echocardiography Laboratory and the UCSF Adult Congenital Heart Disease Clinic. He has played an integral role in the development of many diagnostic and treatment techniques including two dimensional echocardiography, transesophogeal echocardiography, Doppler pulmonary pressure determination, myocardial contrast perfusion and echocardiography phase imaging for ventricular coordination. In the areas of structural heart disease, he is an expert in the treatment of mitral and aortic valve diseases, hypertrophic cardiomyopathy and congenital heart diseases.

RESEARCH INTERESTS: In collaboration with his colleagues, Schiller is involved in research in quantitation of cardiac function and structure, the biology and function of the left atrium, exercise physiology and hemodynamics in heart disease, body composition in heart disease, adult congenital heart disease, three-dimensional reconstruction, echocardiographic contrast agents for quantitation and myocardial perfusion, transesophageal echocardiography, physiology of renal disease, and outcomes in coronary disease as predicted by quantitative phenotyping,

Research Funding

  • October 1, 1974 - November 30, 2007 - General Clinical Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR000083

Education

Union College, Schenectady, New York, BS, 1962
State University of New York at Buffalo, Buffalo NY, MD, 1966
Medical Intern, Ochsner Medical Foundation, New Orleans, LA, 1966-1967
Medical Resident, University of California at San Diego, CA, 1967-1971
USPHS Clinical Cardiology Trainee, University of California at San Francisco, CA, 1971-1973

Honors & Awards

  • 1966
    Thesis Honors, State University of New York at Buffalo, School of Medicine
  • 1981
    Honorary Member, Venezuelan Society of Cardiology, Elected May 29, 1981
  • 1982
    Gustav Nylin Lecturer, Swedish Society of Medical Sciences, Stockholm
  • 1/21/1983
    Commendation by UC President Saxon and by UCSF Chancellor Krevans for Development of Intraoperative Transesophageal Echocardiography in "A Report to the Regents"
  • 4/5/1991
    Karolinska Institute, Stockholm - Thesis opponent
  • 1994-1998
    The Best Doctors in America (Pacific Region)
  • 1997, 1998, 1999
    The Best Doctors in San Francisco, San Francisco Focus Magazine, San Francisco Chronicle and Examiner
  • 1997-98
    UCSF Clinical Cardiology Fellows Award for Outstanding Teacher

Selected Publications

  1. Wong JM, Abouzeid CM, Nguyen TD, Fang Q, Bibby D, Schiller NB. Interrater reproducibility of the 2016 American society of echocardiography left ventricular diastolic function guidelines. Echocardiography. 2022 May; 39(5):678-684.  View on PubMed
  2. Lu DY, Beyer AT, Pursnani SK, Shaw RE, Fang Q, Bibby D, Rosenblatt A, Schiller NB. Left ventricular end-systolic volume response post-stress echocardiography: Dilation as a marker of multi-vessel coronary artery disease. Echocardiography. 2022 02; 39(2):215-222.  View on PubMed
  3. Higuchi S, Kim EJ, Gerstenfeld EP, Bibby D, Schiller NB, Hsia HH. Atrial and ventricular cardiomyopathy associated with premature atrial contractions: Speckle-tracking echocardiography demonstrates reversibility following successful ablation. HeartRhythm Case Rep. 2022 Apr; 8(4):243-246.  View on PubMed
  4. Bhatt A, Flink L, Lu DY, Fang Q, Bibby D, Schiller NB. Exercise physiology of the left atrium: quantity and timing of contribution to cardiac output. Am J Physiol Heart Circ Physiol. 2021 02 01; 320(2):H575-H583.  View on PubMed
  5. Schiller NB, Wong JM. From Doppler to Dante: Common and Avoidable Malfeasance in Echocardiography. J Am Soc Echocardiogr. 2021 02; 34(2):199-200.  View on PubMed
  6. Flink L, Parwani P, Ursell PC, Bibby D, Fang Q, Schiller NB. Left atrial mass: relationship between gross anatomy and quantitative echocardiography. Cardiovasc Pathol. 2020 Nov - Dec; 49:107265.  View on PubMed
  7. Eze-Nliam C, Schiller NB, Hayami D, Ghahghaie F, Bibby D, Fang Q, Marcus GM, Åström Aneq M. Endurance exercise in seniors: Tonic, toxin or neither? Clin Physiol Funct Imaging. 2020 Sep; 40(5):320-327.  View on PubMed
  8. Thadani SR, Shaw RE, Fang Q, Whooley MA, Schiller NB. Left Atrial End-Diastolic Volume Index as a Predictor of Cardiovascular Outcomes: The Heart and Soul Study. Circ Cardiovasc Imaging. 2020 04; 13(4):e009746.  View on PubMed
  9. Mishra RK, Tison GH, Fang Q, Scherzer R, Whooley MA, Schiller NB. Association of Machine Learning-Derived Phenogroupings of Echocardiographic Variables with Heart Failure in Stable Coronary Artery Disease: The Heart and Soul Study. J Am Soc Echocardiogr. 2020 03; 33(3):322-331.e1.  View on PubMed
  10. Desai YB, Mishra RK, Fang Q, Whooley MA, Schiller NB. Association of Longitudinal Change in High-Sensitivity Troponin with All-Cause Mortality in Coronary Artery Disease: The Heart and Soul Study. Cardiology. 2020; 145(2):63-70.  View on PubMed
  11. Abuzaid A, Cohen BE, Pursnani S, Lahsaeizadeh S, Ristow B, Shaw RE, Rosenblatt A, Fang Q, Schiller NB. Who is young at heart and when? Diastolic Doppler data from the mind your heart study. Echocardiography. 2019 09; 36(9):1744-1746.  View on PubMed
  12. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA. Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Respir Care. 2019 Sep; 64(9):1101-1108.  View on PubMed
  13. Ranjan R, Mostafavi Toroghi H, Pressman GS, Schiller NB. Doppler Recognition of Low or Normal Central Venous Pressure from Continuous Flow from Inferior Vena Cava Into Right Atrium. Am J Cardiol. 2019 08 01; 124(3):448-452.  View on PubMed
  14. Meisel K, Yuan K, Fang Q, Bibby D, Lee R, Schiller NB. Embolic Stroke of Undetermined Source: A Population with Left Atrial Dysfunction. J Stroke Cerebrovasc Dis. 2019 Jul; 28(7):1891-1896.  View on PubMed
  15. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. Echocardiographic determination of pulmonary arterial capacitance. Int J Cardiovasc Imaging. 2019 Sep; 35(9):1581-1586.  View on PubMed
  16. Ermakov S, Gulhar R, Lim L, Bibby D, Fang Q, Nah G, Abraham TP, Schiller NB, Delling FN. Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse. Heart. 2019 07; 105(14):1063-1069.  View on PubMed
  17. Simpson TF, Tyler JM, Thomas RC, Fang Q, Bibby D, Schiller NB. Mitral annular peak systolic and diastolic velocities are characteristic of healthy hearts: A Doppler tissue imaging study. Echocardiography. 2019 03; 36(3):433-438.  View on PubMed
  18. Dubin RF, Whooley M, Pico A, Ganz P, Schiller NB, Meyer C. Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study. PLoS One. 2018; 13(12):e0208042.  View on PubMed
  19. Fitzpatrick JK, Meyer CS, Schiller NB, Whooley MA, Mishra RK. Ventricular-Vascular Coupling at Rest and after Exercise Is Associated with Heart Failure Hospitalizations in Patients With Coronary Artery Disease. J Am Soc Echocardiogr. 2018 11; 31(11):1212-1220.e3.  View on PubMed
  20. Ranjan R, Valez EM, Haldipur A, Schiller NB. Relation of Velocity-Time Integral of the Left Ventricular Outflow Tract to that of the Descending Thoracic Aorta and Usefulness of a Fixed Ratio for Internal Validation. Am J Cardiol. 2018 07 01; 122(1):166-169.  View on PubMed

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