Research Summary

Dr. Jess Scholey is an Assistant Professor, Physics Director of the MRI Simulation Program, and Physics Lead of the Proton Ocular Program in the Department of Radiation Oncology at the University of California, San Francisco. She received her BA in Physics from UC Berkeley and went on to receive her MSc and clinical residency training in medical physics from The University of Pennsylvania. Upon completion of her clinical training and ABR certification, she received her PhD from the Joint UC Berkeley-UCSF Bioengineering Program. She joined the faculty in 2017 and focuses on radiation oncology applications of MRI, proton therapy, and deep learning using medical imaging. Dr. Scholey leads the educational curriculum of MRI and proton therapy in the Department of Radiation Oncology and is an active member of the American Association of Physicists in Medicine, International Society for Magnetic Resonance in Medicine, Particle Therapy Co-Operative Group, and the UCSF Center for Intelligent Imaging.

Education

2022 - Diversity, Equity, and Inclusion Champion Training, The University of California
PhD, 2021 - Bioengineering, The University of California
M.S., 2015 - Medical Physics, The University of Pennsylvania
B.A, 2012 - Physics, The University of California, Berkeley

Selected Publications

  1. April Chau OW, Geoghegan T, Everts J, Chen J, Feng M, Chen WC, Scholey JE, Yang Y, Ohliger MA, Sheng K, Miao X, Fan Z, Yang W. Multi-contrast 4DMR via MR multitasking: Early clinical experience and implication for liver stereotactic body radiation therapy. Radiother Oncol. 2025 May; 206:110839.  View on PubMed
  2. Nisanova A, Park SS, Amin A, Zako C, Wilson MD, Scholey J, Afshar AR, Tsai T, Char DH, Mishra KK. Novel Risk Factors for Uveal Melanoma in Adolescent and Young Adult Patients: A Comprehensive Case-Control Analysis. Ophthalmol Sci. 2025 Jul-Aug; 5(4):100687.  View on PubMed
  3. Baniel CC, Sabol RA, Nieto R, Scholey J, Witztum A, Chuter R, Pollom E, Gandhi S, Wang K, Mishra KK, Lichter KE, Park C. Green Horizons in Oncology: A Blueprint for Environmentally Sustainable Radiation Therapy Facilities. Semin Radiat Oncol. 2024 Oct; 34(4):426-432.  View on PubMed
  4. Chen J, Christodoulou AG, Han P, Xiao J, Han F, Hu Z, Wang N, Han H, Ling DC, Chang EL, Feng M, Scholey JE, Cui S, Li D, Yang W, Fan Z. Abdominal MR Multitasking for radiotherapy treatment planning: A motion-resolved and multicontrast 3D imaging approach. Magn Reson Med. 2025 Jan; 93(1):108-120.  View on PubMed
  5. Gao Y, Chang CW, Mandava S, Marants R, Scholey JE, Goette M, Lei Y, Mao H, Bradley JD, Liu T, Zhou J, Sudhyadhom A, Yang X. Author Correction: MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study. Sci Rep. 2024 Jun 25; 14(1):14647.  View on PubMed
  6. Xu D, Miao X, Liu H, Scholey JE, Yang W, Feng M, Ohliger M, Lin H, Lao Y, Yang Y, Sheng K. Paired conditional generative adversarial network for highly accelerated liver 4D MRI. Phys Med Biol. 2024 Jun 17; 69(12).  View on PubMed
  7. Scholey J, Nano T, Singhrao K, Mohamad O, Singer L, Larson PEZ, Descovich M. Linac- and CyberKnife-based MRI-only treatment planning of prostate SBRT using an optimized synthetic CT calibration curve. J Appl Clin Med Phys. 2024 Sep; 25(9):e14411.  View on PubMed
  8. Gao Y, Chang CW, Mandava S, Marants R, Scholey JE, Goette M, Lei Y, Mao H, Bradley JD, Liu T, Zhou J, Sudhyadhom A, Yang X. MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study. Sci Rep. 2024 05 15; 14(1):11166.  View on PubMed
  9. Singhrao K, Dugan CL, Calvin C, Pelayo L, Yom SS, Chan JW, Scholey JE, Singer L. Evaluating the Hounsfield unit assignment and dose differences between CT-based standard and deep learning-based synthetic CT images for MRI-only radiation therapy of the head and neck. J Appl Clin Med Phys. 2024 Jan; 25(1):e14239.  View on PubMed
  10. Massachi J, Singer L, Glastonbury C, Scholey J, Singhrao K, Calvin C, Yom SS, Chan JW. Incidental findings and safety events from magnetic resonance imaging simulation for head and neck radiation treatment planning: A single institution experience. Tech Innov Patient Support Radiat Oncol. 2024 Mar; 29:100228.  View on PubMed
  11. Singhrao K, Zubair M, Nano T, Scholey JE, Descovich M. End-to-end validation of fiducial tracking accuracy in robotic radiosurgery using MRI-only simulation imaging. Med Phys. 2024 Jan; 51(1):31-41.  View on PubMed
  12. Valdes G, Scholey J, Nano TF, Gennatas ED, Mohindra P, Mohammed N, Zeng J, Kotecha R, Rosen LR, Chang J, Tsai HK, Urbanic JJ, Vargas CE, Yu NY, Ungar LH, Eaton E, Simone CB. Predicting the Effect of Proton Beam Therapy Technology on Pulmonary Toxicities for Patients With Locally Advanced Lung Cancer Enrolled in the Proton Collaborative Group Prospective Clinical Trial. Int J Radiat Oncol Biol Phys. 2024 May 01; 119(1):66-77.  View on PubMed
  13. Chang CW, Marants R, Gao Y, Goette M, Scholey JE, Bradley JD, Liu T, Zhou J, Sudhyadhom A, Yang X. Multimodal imaging-based material mass density estimation for proton therapy using supervised deep learning. Br J Radiol. 2023 Dec; 96(1152):20220907.  View on PubMed
  14. Marants R, Tattenberg S, Scholey J, Kaza E, Miao X, Benkert T, Magneson O, Fischer J, Vinas L, Niepel K, Bortfeld T, Landry G, Parodi K, Verburg J, Sudhyadhom A. Validation of an MR-based multimodal method for molecular composition and proton stopping power ratio determination using ex vivo animal tissues and tissue-mimicking phantoms. Phys Med Biol. 2023 08 28; 68(17).  View on PubMed
  15. Jiao C, Ling D, Bian S, Vassantachart A, Cheng K, Mehta S, Lock D, Zhu Z, Feng M, Thomas H, Scholey JE, Sheng K, Fan Z, Yang W. Contrast-Enhanced Liver Magnetic Resonance Image Synthesis Using Gradient Regularized Multi-Modal Multi-Discrimination Sparse Attention Fusion GAN. Cancers (Basel). 2023 Jul 08; 15(14).  View on PubMed
  16. Singer L, Scholey J. Finding Resonance: Using MRI to Improve the Care of Oligometastatic Disease. Int J Radiat Oncol Biol Phys. 2022 12 01; 114(5):936-940.  View on PubMed
  17. Claessens M, Oria CS, Brouwer CL, Ziemer BP, Scholey JE, Lin H, Witztum A, Morin O, Naqa IE, Van Elmpt W, Verellen D. Quality Assurance for AI-Based Applications in Radiation Therapy. Semin Radiat Oncol. 2022 10; 32(4):421-431.  View on PubMed
  18. Scholey JE, Rajagopal A, Vasquez EG, Sudhyadhom A, Larson PEZ. Generation of synthetic megavoltage CT for MRI-only radiotherapy treatment planning using a 3D deep convolutional neural network. Med Phys. 2022 Oct; 49(10):6622-6634.  View on PubMed
  19. Thomas HR, Miao X, Ferguson D, Calvin C, Bhaskar Krishnamurthy U, Anwar M, Feng M, Scholey J. Contrast-enhanced 4D-MRI for internal target volume generation in treatment planning for liver tumors. Radiother Oncol. 2022 08; 173:69-76.  View on PubMed
  20. Scholey J, Vinas L, Kearney V, Yom S, Larson PEZ, Descovich M, Sudhyadhom A. Improved accuracy of relative electron density and proton stopping power ratio through CycleGAN machine learning. Phys Med Biol. 2022 05 02; 67(10).  View on PubMed

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