Research Summary

I am a Genitourinary and Molecular Pathologist with interest in tumors of the kidney, prostate, urinary bladder and testis. My research focuses on study of rare and common subtypes of renal tumors, and the molecular biology of renal tumors and prostate carcinoma.

Education

  • Armed Forces Medical College, Pune, India, MBBS, 1993
  • Armed Forces Medical College, Pune, India, MD, 2000
  • University of Texas Health Science Center at San Antonio, Residency, 2015
  • Cedars-Sinai Medical Center, Fellow, 2016
  • University of California, San Francisco, CA, Fellow, 2017

Selected Publications

  1. Repetto F, Sirohi D, Greipp P, Mahlow J. Incidental Detection of TFEB-Amplified Renal Cell Carcinoma by Colocated Gene Amplification of CCND3 (6p21): A Case Report and Review of the Literature. Int J Surg Pathol. 2024 May;32(3):551-555. doi: 10.1177/10668969231185081. Epub 2023 Jul 2. Review. PubMed PMID: 37394760.
  2. Wilcock DM, Moore KH, Rowe L, Mahlow J, Jedrzkiewicz J, Cleary AS, Lomo L, Ruano AL, Gering M, Bradshaw D, Maughan M, Tran P, Burlingame J, Davis R, Affolter K, Albertson DJ, Adelhardt P, Kim JT, Coleman JF, Deftereos G, Gulbahce EH, Sirohi D. Quantitative Imaging Analysis Fluorescence In Situ Hybridization Validation for Clinical HER2 Testing in Breast Cancer. Arch Pathol Lab Med. 2023 Dec 1;147(12):1402-1412. doi: 10.5858/arpa.2022-0372-OA. PubMed PMID: 36920020.
  3. Maughan BL, Sirohi D. Papillary Renal Cell Carcinoma: A Review of Prospective Clinical Trials. Curr Treat Options Oncol. 2023 Sep;24(9):1199-1212. doi: 10.1007/s11864-023-01107-x. Epub 2023 Jul 6. Review. PubMed PMID: 37407886.
  4. Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J. Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists. Int J Surg Pathol. 2023 Sep;31(6):993-1005. doi: 10.1177/10668969221116629. Epub 2022 Aug 9. PubMed PMID: 35946087.
  5. Li H, Sahu KK, Brundage J, Benson M, Swami U, Boucher KM, Gupta S, Hawks J, Sirohi D, Agarwal N, Maughan BL. Phase I Trial of Combination Therapy With Avelumab and Cabozantinib in Patients With Newly Diagnosed Metastatic Clear Cell Renal Cell Carcinoma. Oncologist. 2023 Aug 3;28(8):737-e693. doi: 10.1093/oncolo/oyad019. PubMed PMID: 36952231; PubMed Central PMCID: PMC10400129.
  6. Schwartz CJ, Ruiz J, Bean GR, Sirohi D, Joseph NM, Hosfield EM, Jacobs TW, Mukhtar RA, Chen YY, Krings G. Triple-Negative Apocrine Carcinomas: Toward a Unified Group With Shared Molecular Features and Clinical Behavior. Mod Pathol. 2023 May;36(5):100125. doi: 10.1016/j.modpat.2023.100125. Epub 2023 Feb 6. PubMed PMID: 36870308.
  7. McMurtry V, Mahlow J, Coleman JF, Deftereos G, Jattani R, Bastien RRL, Durtschi J, Jarboe E, Lomo L, Sirohi D. Morphologic Characteristics and Mutational Analysis of Fumarate Hydratase Deficient Kidney and Smooth Muscle Tumors. Am J Clin Pathol. 2023 Feb 1;159(2):164-171. doi: 10.1093/ajcp/aqac148. PubMed PMID: 36495298.
  8. Zhang W, Koh MY, Sirohi D, Ying J, Brintz BJ, Knudsen BS. Predicting IHC staining classes of NF1 using features in the hematoxylin channel. J Pathol Inform. 2023;14:100196. doi: 10.1016/j.jpi.2023.100196. eCollection 2023. PubMed PMID: 36814440; PubMed Central PMCID: PMC9939724.
  9. McFarland TR, Mathew Thomas V, Nussenzveig R, Gebrael G, Sayegh N, Tripathi N, Sahu KK, Goel D, Maughan BL, Sirohi D, Agarwal N, Swami U. Detection of BRCA1, and BRCA2 Alterations in Matched Tumor Tissue and Circulating Cell-Free DNA in Patients with Prostate Cancer in a Real-World Setting. Biomedicines. 2022 Dec 7;10(12). doi: 10.3390/biomedicines10123170. PubMed PMID: 36551924; PubMed Central PMCID: PMC9776086.
  10. Swami U, Sayegh N, Jo Y, Haaland B, McFarland TR, Nussenzveig RH, Goel D, Sirohi D, Hahn AW, Maughan BL, Goldkorn A, Agarwal N. External Validation of Association of Baseline Circulating Tumor Cell Counts with Survival Outcomes in Men with Metastatic Castration-Sensitive Prostate Cancer. Mol Cancer Ther. 2022 Dec 2;21(12):1857-1861. doi: 10.1158/1535-7163.MCT-22-0020. PubMed PMID: 36198026.
  11. Winter JM, Fresenius HL, Cunningham CN, Wei P, Keys HR, Berg J, Bott A, Yadav T, Ryan J, Sirohi D, Tripp SR, Barta P, Agarwal N, Letai A, Sabatini DM, Wohlever ML, Rutter J. Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction. Elife. 2022 Nov 21;11. doi: 10.7554/eLife.82860. PubMed PMID: 36409067; PubMed Central PMCID: PMC9815822.
  12. Mahlow J, Sanchez A, Barry M, Sirohi D. Composite pheochromocytoma/paraganglioma-ganglioneuroma with a germline SDHC mutation: a first of its kind case report. Histopathology. 2022 Nov;81(5):682-685. doi: 10.1111/his.14776. Epub 2022 Aug 31. PubMed PMID: 36045543.
  13. Tripathi N, Jo Y, Tripathi A, Sayegh N, Li H, Nussenzveig R, Haaland B, Thomas VM, Gupta S, Maughan BL, Swami U, Pal SK, Grivas P, Agarwal N, Sirohi D. Genomic landscape of locally advanced or metastatic urothelial carcinoma with squamous differentiation compared to pure urothelial carcinoma. Urol Oncol. 2022 Nov;40(11):493.e1-493.e7. doi: 10.1016/j.urolonc.2022.07.002. Epub 2022 Jul 30. PubMed PMID: 35918248.
  14. Green YS, Ferreira Dos Santos MC, Fuja DG, Reichert EC, Campos AR, Cowman SJ, Acuña Pilarte K, Kohan J, Tripp SR, Leibold EA, Sirohi D, Agarwal N, Liu X, Koh MY. ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. Oncogene. 2022 Oct;41(42):4709-4723. doi: 10.1038/s41388-022-02460-1. Epub 2022 Sep 12. PubMed PMID: 36097192; PubMed Central PMCID: PMC9568429.
  15. Wilcock DM, McMurtry V, Coleman JF, Kim JT, Khalili P, Deftereos G, Albertson D, Gulbahce EH, Liu T, Sirohi D. Histopathological Correlation of Chromosome 12 Polysomy by Fluorescence in Situ Hybridization in Adipocytic Neoplasms. Int J Surg Pathol. 2022 Oct;30(7):734-742. doi: 10.1177/10668969221085289. Epub 2022 Mar 9. PubMed PMID: 35261272.
  16. Wilcock DM, Sirohi D, Coleman JF, Gulbahce HE. Digital imaging correlation of immunohistochemistry and fluorescence in situ hybridization in breast carcinoma cases with HER2 genetic heterogeneity. Hum Pathol. 2022 Aug;126:129-135. doi: 10.1016/j.humpath.2022.05.011. Epub 2022 May 24. PubMed PMID: 35623464.
  17. Sirohi D, Chipman J, Barry M, Albertson D, Mahlow J, Liu T, Raps E, Haaland B, Sayegh N, Li H, Rathi N, Sharma P, Agarwal N, Knudsen B. Histologic Growth Patterns in Clear Cell Renal Cell Carcinoma Stratify Patients into Survival Risk Groups. Clin Genitourin Cancer. 2022 Jun;20(3):e233-e243. doi: 10.1016/j.clgc.2022.01.005. Epub 2022 Jan 13. PubMed PMID: 35125301.
  18. Smith SC, Hamza A, Sirohi D, Amin MB. Response to the Letter to the Editor Entitled "Do We Have Sufficient Evidence to Define Prognosis for 'Low-grade' Fumarate Hydratase-deficient Renal Cell Carcinoma?". Adv Anat Pathol. 2022 May 1;29(3):181-182. doi: 10.1097/PAP.0000000000000340. PubMed PMID: 35249991.
  19. Jedrzkiewicz J, Sirohi D, Uvejzovic N, Gulbahce HE. RAI1 alternate probe identifies additional gastroesophageal adenocarcinoma cases as amplified following equivocal HER2 fluorescence in situ hybridization testing: experience from a national reference laboratory. Mod Pathol. 2022 Apr;35(4):549-553. doi: 10.1038/s41379-021-00933-4. Epub 2021 Oct 18. PubMed PMID: 34663915.
  20. Wilcock DM, Schmidt RL, Furtado LV, Matynia AP, Deftereos G, Sirohi D. Histologic and Molecular Characterization of Non-Small Cell Lung Carcinoma With Discordant ROS1 Immunohistochemistry and Fluorescence In Situ Hybridization. Appl Immunohistochem Mol Morphol. 2022 Jan 1;30(1):19-26. doi: 10.1097/PAI.0000000000000973. PubMed PMID: 34534989.

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