Research Summary

I have extensive experience with developing tissue-based biomarker techniques and with directing biorepositories for the optimal acquisition, archiving, annotation, and custodianship of human tissue for cancer research. The techniques that I have expertise with in molecular morphology include immunohistochemistry / immunofluorescence and molecular in situ analyses. A major emphasis of my technical research core activities since 2008 has been to develop more quantitative detection of biomarkers of activated signaling pathways in a wide spectrum of human disease, focusing on cancer. My translational research focuses on the application of multiple proteomic, epigenetic and genetic techniques for the molecular morphologic analysis of biomarkers in CNS tumor sections. The technologies include processing techniques for tissue to preserve analyte quality for RNA, DNA and proteomics with optimal histologic quality and multiple detection modalities on tissue sections for biomarker multiplexing in heterogeneous tumors, including the genomic and proteomic characterization of prognostic markers in CNS tumors. I directed the establishment of a tissue technology laboratory to optimize the use of quantitative immunofluorescence detection techniques for combined IF/ISH analyses and for the multiplex analysis of inter-related signaling pathways in human tissue, focusing on cancer. Before coming to UCSF, I was Director of the UCSD Moores Comprehensive Center Biorepository, Histopathology, and Tissue Technology Shared Resource in 2012-2015.

Research Funding

  • August 1, 2018 - July 31, 2019 - A shared resource for multiplexed ion beam imaging microscopy, Principal Investigator. Sponsor: NIH, Sponsor Award ID: S10OD025187
  • July 1, 1983 - June 30, 1993 - NEUROPATHOLOGY RESEARCH, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: T32NS007236
  • April 15, 1986 - March 31, 1990 - MONOAMINES IN EMBRYONAL CNS TUMOR DIFFERENTIATION, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS022455
  • July 1, 1984 - June 30, 1989 - MONOAMINES IN EMBRYONAL CNS TUMOR DIFFERENTIATION, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K07NS000854

Education

Duke University, BS, 1968-1972, Zoology
Stanford University School of Medicine, MD, PhD, 1968-1972, Medicine/Neurosciences
University of Colorado, Intern, 1979-1980, Pathology
Stanford University School of Medicine, Postdoctoral Fellow, 1980-1982, Neurochemistry/Neuropathology
University of Virginia, Residency Fellowship, 1982-1984, Pathology/Neuropathology

Honors & Awards

  • 1971
    Phi Beta Kappa, Junior Year Election, Duke University
  • 1972
    Graduation Summa Cum Laude with Distinction in Zoology, Duke University
  • 1972
    Edward C. Horn Memorial Prize for Excellence in Zoology
  • 1974
    Weil Award, American Association of Neuropathologists
  • 1974-1976
    Scholar of the Insurance Medical Scientist Fund, Stanford University School of Medicine
  • 1990
    Charter Member, Diagnostic Slide Session of the American Association of Neuropathologists
  • 2003-2004
    Vice President, American Association of Neuropathologists

Selected Publications

  1. Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors.  View on PubMed
  2. Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.  View on PubMed
  3. Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer.  View on PubMed
  4. Browne SH, Diaz-Perez JA, Preziosi M, King CC, Jones GA, Jain S, Sun X, Reid EG, VandenBerg S, Wang HY mTOR activity in AIDS-related diffuse large B-cell lymphoma.  View on PubMed
  5. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.  View on PubMed
  6. van Draanen J, Davidson P, Bour-Jordan H, Bowman-Carpio L, Boyle D, Dubinett S, Gardner B, Gardner J, McFall C, Mercola D, Nakazono T, Soares S, Stoppler H, Tempero M, Vandenberg S, Wan YJ, Dry S Assessing Researcher Needs for a Virtual Biobank.  View on PubMed
  7. Sheth V, Shao H, Chen J, Vandenberg S, Corey-Bloom J, Bydder GM, Du J Magnetic resonance imaging of myelin using ultrashort Echo time (UTE) pulse sequences: Phantom, specimen, volunteer and multiple sclerosis patient studies.  View on PubMed
  8. van Vugt VA, Kesari A, Muller KA, Carter B, Vandenberg SR, Kesari S A 22-Year Old Woman with Right Eyelid Swelling.  View on PubMed
  9. Jones KA, Gilder AS, Lam MS, Du N, Banki MA, Merati A, Pizzo DP, VandenBerg SR, Gonias SL Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature.  View on PubMed
  10. Barajas RF, Phillips JJ, Vandenberg SR, McDermott MW, Berger MS, Dillon WP, Cha S Pro-angiogenic cellular and genomic expression patterns within glioblastoma influences dynamic susceptibility weighted perfusion MRI.  View on PubMed
  11. Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR, Chen CC Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.  View on PubMed
  12. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, Jain R, Joseph I, Kim J, Kasaian K, Mikkelsen T, Murray BA, O'Neill BP, Pachter L, Parsons DW, Sougnez C, Sulman EP, Vandenberg SR, Van Meir EG, von Deimling A, Zhang H, Crain D, Lau K, Mallery D, Morris S, Paulauskis J, Penny R, Shelton T, Sherman M, Yena P, Black A, Bowen J, Dicostanzo K, Gastier-Foster J, Leraas KM, Lichtenberg TM, Pierson CR, Ramirez NC, Taylor C, Weaver S, Wise L, Zmuda E, Davidsen T, Demchok JA, Eley G, Ferguson ML, Hutter CM, Mills Shaw KR, Ozenberger BA, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Ayala B, Baboud J, Chudamani S, Jensen MA, Liu J, Pihl T, Raman R, Wan Y, Wu Y, Ally A, Auman JT, Balasundaram M, Balu S, Baylin SB, Beroukhim R, Bootwalla MS, Bowlby R, Bristow CA, Brooks D, Butterfield Y, Carlsen R, Carter S, Chin L, Chu A, Chuah E, Cibulskis K, Clarke A, Coetzee SG, Dhalla N, Fennell T, Fisher S, Gabriel S, Getz G, Gibbs R, Guin R, Hadjipanayis A, Hayes DN, Hinoue T, Hoadley K, Holt RA, Hoyle AP, Jefferys SR, Jones S, Jones CD, Kucherlapati R, Lai PH, Lander E, Lee S, Lichtenstein L, Ma Y, Maglinte DT, Mahadeshwar HS, Marra MA, Mayo M, Meng S, Meyerson ML, Mieczkowski PA, Moore RA, Mose LE, Mungall AJ, Pantazi A, Parfenov M, Park PJ, Parker JS, Perou CM, Protopopov A, Ren X, Roach J, Sabedot TS, Schein J, Schumacher SE, Seidman JG, Seth S, Shen H, Simons JV, Sipahimalani P, Soloway MG, Song X, Sun H, Tabak B, Tam A, Tan D, Tang J, Thiessen N, Triche T, Van Den Berg DJ, Veluvolu U, Waring S, Weisenberger DJ, Wilkerson MD, Wong T, Wu J, Xi L, Xu AW, Yang L, Zack TI, Zhang J, Aksoy BA, Arachchi H, Benz C, Bernard B, Carlin D, Cho J, DiCara D, Frazer S, Fuller GN, Gao J, Gehlenborg N, Haussler D, Heiman DI, Iype L, Jacobsen A, Ju Z, Katzman S, Kim H, Knijnenburg T, Kreisberg RB, Lawrence MS, Lee W, Leinonen K, Lin P, Ling S, Liu W, Liu Y, Liu Y, Lu Y, Mills G, Ng S, Noble MS, Paull E, Rao A, Reynolds S, Saksena G, Sanborn Z, Sander C, Schultz N, Senbabaoglu Y, Shen R, Shmulevich I, Sinha R, Stuart J, Sumer SO, Sun Y, Tasman N, Taylor BS, Voet D, Weinhold N, Weinstein JN, Yang D, Yoshihara K, Zheng S, Zhang W, Zou L, Abel T, Sadeghi S, Cohen ML, Eschbacher J, Hattab EM, Raghunathan A, Schniederjan MJ, Aziz D, Barnett G, Barrett W, Bigner DD, Boice L, Brewer C, Calatozzolo C, Campos B, Carlotti CG, Chan TA, Cuppini L, Curley E, Cuzzubbo S, Devine K, DiMeco F, Duell R, Elder JB, Fehrenbach A, Finocchiaro G, Friedman W, Fulop J, Gardner J, Hermes B, Herold-Mende C, Jungk C, Kendler A, Lehman NL, Lipp E, Liu O, Mandt R, McGraw M, Mclendon R, McPherson C, Neder L, Nguyen P, Noss A, Nunziata R, Ostrom QT, Palmer C, Perin A, Pollo B, Potapov A, Potapova O, Rathmell WK, Rotin D, Scarpace L, Schilero C, Senecal K, Shimmel K, Shurkhay V, Sifri S, Singh R, Sloan AE, Smolenski K, Staugaitis SM, Steele R, Thorne L, Tirapelli DP, Unterberg A, Vallurupalli M, Wang Y, Warnick R, Williams F, Wolinsky Y, Bell S, Rosenberg M, Stewart C, Huang F, Grimsby JL, Radenbaugh AJ, Zhang J Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.  View on PubMed
  13. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.  View on PubMed
  14. Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.  View on PubMed
  15. Li J, Taich ZJ, Goyal A, Gonda D, Akers J, Adhikari B, Patel K, Vandenberg S, Yan W, Bao Z, Carter BS, Wang R, Mao Y, Jiang T, Chen CC Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas.  View on PubMed
  16. Farid N, Almeida-Freitas DB, White NS, McDonald CR, Kuperman JM, Almutairi AA, Muller KA, VandenBerg SR, Kesari S, Dale AM Combining diffusion and perfusion differentiates tumor from bevacizumab-related imaging abnormality (bria).  View on PubMed
  17. Hartman LL, Crawford JR, Makale MT, Milburn M, Joshi S, Salazar AM, Hasenauer B, VandenBerg SR, MacDonald TJ, Durden DL Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors.  View on PubMed
  18. Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.  View on PubMed
  19. Mahta A, Borys E, Vandenberg SR, Carter B, Kesari S 72 year old female with leg weakness.  View on PubMed
  20. Du J, Ma G, Li S, Carl M, Szeverenyi NM, VandenBerg S, Corey-Bloom J, Bydder GM Ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain using a clinical 3T scanner.  View on PubMed

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