Research Summary

I am a physician scientist in the Departments of Radiation Oncology, Neurological Surgery, and Cell and Tissue Biology. My clinical expertise is providing radiotherapy for children and adults with nervous system cancers. My scientific focus is understanding cell signaling with an emphasis on neurofibromatosis and nervous system tumors to develop better tests and treatments for patients.

Research Funding

  • June 4, 2026 - May 31, 2031 - Elucidating the function of NF2 in NF1 mutant peripheral nervous system tumors. , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA304081
  • November 1, 2025 - October 30, 2030 - Directly targeting Ras GTPases in neurofibromatosis type 1 , Principal Investigator . Sponsor: Gilbert Family Foundation, Sponsor Award ID: Gene Therapy Initiative
  • August 1, 2025 - June 30, 2028 - Mapping the RNA Splicing Landscape of NF1 and Its Impact on Neurofibromin Function Across Tissues , Principal Investigator . Sponsor: Department of Defense, Sponsor Award ID: Synergistic Idea Award
  • June 1, 2024 - June 30, 2027 - Dissecting Ras GAP Specificity in the Peripheral Nervous System , Principal Investigator . Sponsor: Department of Defense, Sponsor Award ID: New Investigator Award
  • July 11, 2022 - June 30, 2025 - Francis Collins Scholar , Principal Investigator . Sponsor: Neurofibromatosis Therapeutic Acceleration Program, Sponsor Award ID: unknown
  • January 1, 2023 - December 31, 2024 - Too much of a GAP: full length NF1 reconstitution in neurofibroma and MPNST , Principal Investigator . Sponsor: Children's Tumor Foundation, Sponsor Award ID: Young Investigator Award
  • May 1, 2013 - April 30, 2016 - Transcriptional Targets of PDGF Signaling during Craniofacial Development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F31DE023456

Education

2022 - Radiation Oncology, UCSF
2018 - Internal Medicine, California Pacific Medical Center
MD, PhD, 2017 - Medicine, Neuroscience, Mount Sinai School of Medicine
B.S., 2009 - Biology, California Institute of Technology

Honors & Awards

  • 2017
    SNO Adult Basic Research Abstract Award, Society for Neuro-Oncology
  • 2018
    Graduate Medical Education Research Day Best Poster Award, CPMC
  • 2019-2020
    UCSF Wolfe Meningioma Program Project Fellowship, UCSF
  • 2019-2021
    Children’s Tumor Foundation Young Investigator Award, UCSF
  • 2021 ASTRO
    Annual Meeting Resident Abstract Award, American Society for Radiation Oncology
  • 2021
    Top Peripheral Nerve Paper of the Year, Congress of Neurological Surgeons
  • 2021
    SNO Young Investigator Forum Award Winner, Society for Neuro-Oncology
  • 2020-2022
    Holman Pathway Research Fellowship, American Board of Radiology
  • 2022
    Roentgen Resident/Fellow Research Award, Radiological Society of North America
  • 2022-2025
    Francis Collins Scholar Award, Neurofibromatosis Therapeutic Acceleration Program

Selected Publications

  1. Pan S, Mirchia K, Payne E, Liu SJ, Al-Adli N, Peeran Z, Shukla P, Young JS, Gupta R, Wu J, Pak J, Ozawa T, Na B, Reddy AT, Braunstein SE, Phillips JJ, Chang S, Solomon DA, Perry A, Raleigh DR, Berger MS, Abate AR, Vasudevan HN. Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma. JCI Insight. 2025 Sep 23; 10(18). View on PubMed
  2. Lin K, Zou C, Hubbard A, Sengelmann S, Goudy L, Wang IC, Sharma R, Pak J, Foster K, Ozawa T, de Groot JF, Phillips J, Vasudevan HN, Raleigh DR, Marson A, Murthy N, Gilbert LA, Berger MS, Liu SJ. Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy. Neuro Oncol. 2025 Jul 30; 27(6):1443-1457. View on PubMed
  3. Vasudevan HN, Arang N, Sacconi Nunez M, Kennedy P, Payne E, Mohabeer S, Chien J, Wright A, Sale MJ, Krogan NJ, Forget A, McCormick F. A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system. View on PubMed
  4. Barrios J, Porter E, Capaldi DPI, Upadhaya T, Chen WC, Perks JR, Apte A, Aristophanous M, LoCastro E, Hsu D, Stone PH, Villanueva-Meyer JE, Valdes G, Jiang F, Maddalena M, Ballangrud A, Prezelski K, Lin H, Sun JY, Aldin MAK, Chau OW, Ziemer B, Seaberg M, Sneed PK, Nakamura JL, Boreta LC, Fogh SE, Raleigh DR, Chew J, Vasudevan H, Cha S, Hess C, Fragoso R, Shultz DB, Pike L, Hervey-Jumper SL, Tsang DS, Theodosopoulos P, Cooke D, Benedict SH, Sheng K, Seuntjens J, Coolens C, Deasy JO, Braunstein S, Morin O. Author Correction: Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy. Nat Commun. 2025 Jun 02; 16(1):5096. View on PubMed
  5. Barrios J, Porter E, Capaldi DPI, Upadhaya T, Chen WC, Perks JR, Apte A, Aristophanous M, LoCastro E, Hsu D, Stone PH, Villanueva-Meyer JE, Valdes G, Jiang F, Maddalena M, Ballangrud A, Prezelski K, Lin H, Sun JY, Aldin MAK, Chau OW, Ziemer B, Seaberg M, Sneed PK, Nakamura JL, Boreta LC, Fogh SE, Raleigh DR, Chew J, Vasudevan H, Cha S, Hess C, Fragoso R, Shultz DB, Pike L, Hervey-Jumper SL, Tsang DS, Theodosopoulos P, Cooke D, Benedict SH, Sheng K, Seuntjens J, Coolens C, Deasy JO, Braunstein S, Morin O. Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy. Nat Commun. 2025 May 15; 16(1):4536. View on PubMed
  6. Raleigh D, Mirchia K, Oten S, Picart T, Nguyen M, Ambati V, Vasudevan H, Young J, Taylor J, Krishna S, Brang D, Phillips J, Perry A, Berger M, Chang S, de Groot J, Hervey-Jumper S. Spatial synaptic connectivity underlies oligodendroglioma evolution and recurrence. Res Sq. 2025 Apr 04. View on PubMed
  7. Shukla PD, Nguyen MP, Lui A, Catalan T, Young JS, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Huppert LA, Aghi MK, Vasudevan HN, Morshed RA. Association of lower tumor mutation burden with rapid local progression in patients with brain metastases. J Neurosurg. 2025 Jun 01; 142(6):1701-1709. View on PubMed
  8. Vasudevan HN, Lazar AA, Reyes K, Rong DA, Arevalo S, Federman S, Chan JW, Chiu CY, Miller S, Yom SS. Comparison of Plasma Metagenomic Next-generation Sequencing and PCR Methods for Epstein-Barr Virus Viral Load Monitoring in Nasopharyngeal Carcinoma. Anticancer Res. 2024 Dec; 44(12):5445-5453. View on PubMed
  9. Na B, Shah SR, Vasudevan HN. Correction to: Past, Present, and Future Therapeutic Strategies for NF‑1‑Associated Tumors. Curr Oncol Rep. 2024 Oct; 26(10):1223. View on PubMed
  10. Eaton CD, Avalos L, Liu SJ, Chen Z, Zakimi N, Casey-Clyde T, Bisignano P, Lucas CG, Stevenson E, Choudhury A, Vasudevan HN, Magill ST, Young JS, Krogan NJ, Villanueva-Meyer JE, Swaney DL, Raleigh DR. MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features. Nat Commun. 2024 Sep 09; 15(1):7873. View on PubMed
  11. Vasudevan H, Braunstein S. In Reply to the Letter to the Editor Regarding "Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases". World Neurosurg. 2024 08; 188:252. View on PubMed
  12. Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR. Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest. bioRxiv. 2024 Jul 12. View on PubMed
  13. Huppert LA, Fisch S, Tsopurashvili E, Somepalle SS, Salans M, Vasudevan HN, Jo Chien A, Majure M, Rugo HS, Balassanian R, Boreta L, Melisko ME. Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study. Breast Cancer Res Treat. 2024 Aug; 206(3):625-636. View on PubMed
  14. Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A, Liu SJ, Phillips JJ, Magill ST, Horbinski CM, Solomon DA, Perry A, Vasudevan HN, Heimberger AB, Raleigh DR. Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution. Nat Genet. 2024 Jun; 56(6):1121-1133. View on PubMed
  15. Na B, Shah SR, Vasudevan HN. Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors. Curr Oncol Rep. 2024 Jun; 26(6):706-713. View on PubMed
  16. Haugh AM, Osorio RC, Francois RA, Tawil ME, Tsai KK, Tetzlaff M, Daud A, Vasudevan HN. Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations. Cancers (Basel). 2024 Mar 29; 16(7). View on PubMed
  17. Salans M, Ni L, Morin O, Ziemer B, Capaldi DPI, Raleigh DR, Vasudevan HN, Chew J, Nakamura J, Sneed PK, Boreta L, Villanueva-Meyer JE, Theodosopoulos P, Braunstein S. Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty. J Neurooncol. 2024 Feb; 166(3):535-546. View on PubMed
  18. Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR. Epigenetic reprogramming shapes the cellular landscape of schwannoma. Nat Commun. 2024 Jan 12; 15(1):476. View on PubMed
  19. Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun. 2024 Jan 12; 15(1):477. View on PubMed
  20. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Lam TC, Pu JK, Li LF, Leung GK, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Patel AJ, Sahm F, Magill ST, Raleigh DR. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 12; 29(12):3067-3076. View on PubMed

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