Research Summary

I am a physician scientist in the Departments of Radiation Oncology and Neurological Surgery. My clinical expertise is providing radiotherapy for children and adults with nervous system cancers. My scientific focus is understanding oncogenic growth factor signaling through receptor tyrosine kinases and the Ras signaling pathway with an emphasis on neurofibromatosis and nervous system tumors to identify better treatments for patients.

Research Funding

  • July 11, 2022 - June 30, 2025 - Francis Collins Scholar , Principal Investigator . Sponsor: Neurofibromatosis Therapeutic Acceleration Program, Sponsor Award ID:
  • January 1, 2023 - December 31, 2024 - Too much of a GAP: full length NF1 reconstitution in neurofibroma and MPNST , Principal Investigator . Sponsor: Children's Tumor Foundation, Sponsor Award ID:
  • October 1, 2022 - June 30, 2023 - Therapeutically targeting NF1 loss in glioblastoma , Principal Investigator . Sponsor: UCSF Brain Tumor Center SPORE Career Enhancement Program, Sponsor Award ID:

Education

2022 - Radiation Oncology, UCSF
2018 - Internal Medicine, California Pacific Medical Center
MD, PhD, 2017 - Medicine, Neuroscience, Mount Sinai School of Medicine
B.S., 2009 - Biology, California Institute of Technology

Honors & Awards

  • 2017
    SNO Adult Basic Research Abstract Award, Society for Neuro-Oncology
  • 2018
    Graduate Medical Education Research Day Best Poster Award, CPMC
  • 2019-2020
    UCSF Wolfe Meningioma Program Project Fellowship, UCSF
  • 2019-2021
    Children’s Tumor Foundation Young Investigator Award, UCSF
  • 2021 ASTRO
    Annual Meeting Resident Abstract Award, American Society for Radiation Oncology
  • 2021
    Top Peripheral Nerve Paper of the Year, Congress of Neurological Surgeons
  • 2021
    SNO Young Investigator Forum Award Winner, Society for Neuro-Oncology
  • 2020-2022
    Holman Pathway Research Fellowship, American Board of Radiology
  • 2022
    Roentgen Resident/Fellow Research Award, Radiological Society of North America
  • 2022-2025
    Francis Collins Scholar Award, Neurofibromatosis Therapeutic Acceleration Program

Selected Publications

  1. Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D. Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution. Res Sq. 2023 May 15.  View on PubMed
  2. Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, Lam TC, Pu J, Leung G, Chang J, Perlow H, Palmer J, Haberler C, Berghoff A, Preusser M, Nicolaides T, Mawrin C, Agnihotri S, Resnick A, Rood B, Chew J, Young J, Boreta L, Braunstein S, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer J, Chandler J, Solomon D, Rogers C, Pugh S, Mehta M, Sneed P, Berger M, Horbinski C, McDermott M, Perry A, Bi W, Patel A, Sahm F, Magill S. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Res Sq. 2023 Mar 20.  View on PubMed
  3. Eaton C, Avalos L, Liu SJ, Casey-Clyde T, Bisignano P, Lucas CH, Stevenson E, Choudhury A, Vasudevan H, Magill S, Krogan N, Villanueva-Meyer J, Swaney D, Raleigh D. MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features. Res Sq. 2023 Mar 14.  View on PubMed
  4. Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE. Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases. World Neurosurg. 2023 Feb; 170:e514-e519.  View on PubMed
  5. Peng KL, Vasudevan HN, Lockney DT, Baum R, Hendrickson RC, Raleigh DR, Schmitt AM. Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance. Proc Natl Acad Sci U S A. 2022 09 13; 119(37):e2203738119.  View on PubMed
  6. Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA. Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta Neuropathol. 2022 Oct; 144(4):747-765.  View on PubMed
  7. Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR. Intratumor and informatic heterogeneity influence meningioma molecular classification. Acta Neuropathol. 2022 09; 144(3):579-583.  View on PubMed
  8. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659.  View on PubMed
  9. Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL. A molecularly integrated grade for meningioma. Neuro Oncol. 2022 05 04; 24(5):796-808.  View on PubMed
  10. Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, McDermott MW, Raleigh DR, Braunstein SE. Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors. J Neurosurg. 2022 Jan 21; 1-7.  View on PubMed
  11. Ahmad TR, Vasudevan HN, Lazar AA, Chan JW, George JR, Alvarado MD, Yu SS, Daud A, Yom SS. Should Sentinel Lymph Node Biopsy Status Guide Adjuvant Radiation Therapy in Patients With Merkel Cell Carcinoma? Adv Radiat Oncol. 2021 Nov-Dec; 6(6):100764.  View on PubMed
  12. Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR. Accurate Bulk Quantitation of Droplet Digital Polymerase Chain Reaction. Anal Chem. 2021 07 27; 93(29):9974-9979.  View on PubMed
  13. Wu SY, Yee E, Vasudevan HN, Fogh SE, Boreta L, Braunstein SE, Hong JC. Risk Stratification for Imminent Risk of Death at the Time of Palliative Radiotherapy Consultation. JAMA Netw Open. 2021 07 01; 4(7):e2115641.  View on PubMed
  14. Vasudevan HN, Yom SS. Nasopharyngeal Carcinoma and Its Association with Epstein-Barr Virus. Hematol Oncol Clin North Am. 2021 10; 35(5):963-971.  View on PubMed
  15. Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR. Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy. Neurosurgery. 2021 06 15; 89(1):E99-E101.  View on PubMed
  16. Demaree B, Delley CL, Vasudevan HN, Peretz CAC, Ruff D, Smith CC, Abate AR. Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia. Nat Commun. 2021 03 11; 12(1):1583.  View on PubMed
  17. Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR. Accurate bulk quantitation of droplet digital PCR. bioRxiv. 2021 Jan 15.  View on PubMed
  18. Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR. Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer. Neurosurgery. 2021 01 13; 88(2):234-245.  View on PubMed
  19. Vasudevan HN, Xu P, Servellita V, Miller S, Liu L, Gopez A, Chiu CY, Abate AR. Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification. Sci Rep. 2021 01 12; 11(1):780.  View on PubMed
  20. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR. A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection. Neurosurgery. 2020 12 15; 88(1):202-210.  View on PubMed

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