Research Summary

Daniel B. Vigneron, PhD, is a Professor in the Department of Radiology and Biomedical Imaging and a Professor in the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco. He is also Director of the Advanced Imaging Technologies Resource Group, Director of the Hyperpolarized MRI Technology Resource Center, and Associate Director of the Surbeck Laboratory for Advanced Imaging at UCSF. Dr. Vigneron’s professional activities focus on the advancement of biomedical MRI research. Dr. Vigneron obtained his BA in Chemistry from Wesleyan University in Middletown, Connecticut in 1983, and he received his PhD in Pharmaceutical Chemistry from UCSF in 1988 for his graduate work on applying new MRI techniques for characterizing disease and therapy response. In 1990, he completed a postdoctoral fellowship from the Fox Chase Cancer Center in Philadelphia and in 1991 he completed a postdoctoral scholarship from UCSF.

Dr. Vigneron’s research is focused on the development of metabolic magnetic resonance imaging techniques for research and clinical assessments of human diseases. His initial focus was on developing 3D MR spectroscopic imaging for the non-invasive assessment of brain tumor metabolism. Another major research interest of Dr. Vigneron’s is the characterization of prostate cancer using novel MR metabolic imaging techniques. Developing specialized acquisitions techniques for prostate cancer MRSI has been a major project for Dr. Vigneron and his group.

Dr. Vigneron leads the technical development aspects of hyperpolarized carbon-13 MR program at UCSF and is the Principal Investigator of three projects focused on new metabolic MRI techniques. He has published over 200 articles, over 10 book chapters and over 450 abstracts related to his research.

Research Funding

  • April 11, 2019 - March 31, 2024 - Hyperpolarized C-13 MRI for Early Detection of Aggressive Prostate Cancer in Active Surveillance Patients, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA232320
  • June 1, 2019 - February 29, 2024 - Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI Methods, Principal Investigator. Sponsor: NIH/NIBIB, Sponsor Award ID: U01EB026412
  • March 6, 2017 - February 28, 2022 - CLINICAL TRANSLATION OF HYPERPOLARIZED 13C-UREA FOR CANCER MR MOLECULAR IMAGING, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA214554
  • August 1, 2011 - July 31, 2021 - NIH Biomedical Technology Resource Center (BTRC), Principal Investigator. Sponsor: NIH/NIBIB, Sponsor Award ID: P41 EB013598

Education

Wesleyan University, Middletown, CT, BA, 1983, Chemistry/Pre-Med
University of California San Francisco, CA, PhD, 1988, Pharm. Chemistry
Fox Chase Cancer Center, Philadelphia, PA, Postdoctoral, 1988-90, Medical NMR

Honors & Awards

  • 1998-2000
    Three CapCure Foundation Research Awards
  • 2001
    American Society of Neuroradiology - Outstanding Presentation Award in Pediatric Neuroradiology
  • 2007
    American Society of Neuroradiology – Outstanding Presentation Award
  • 2007
    Elected to the College of Fellows of the American Institute for Medical and Biological Engineering
  • 2009
    International Society of Magnetic Resonance in Medicine Fellowship Award

Selected Publications

  1. Li Y, Vigneron DB, Xu D. Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging. Eur J Nucl Med Mol Imaging. 2021 Aug 25.  View on PubMed
  2. Qin H, Tang S, Riselli AM, Bok RA, Delos Santos R, van Criekinge M, Gordon JW, Aggarwal R, Chen R, Goddard G, Zhang CT, Chen A, Reed G, Ruscitto DM, Slater J, Sriram R, Larson PEZ, Vigneron DB, Kurhanewicz J. Clinical translation of hyperpolarized 13 C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging. Magn Reson Med. 2021 Aug 10.  View on PubMed
  3. Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, Van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB. Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors. Magn Reson Med. 2021 Jul 03.  View on PubMed
  4. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. Denoising of hyperpolarized 13 C MR images of the human brain using patch-based higher-order singular value decomposition. Magn Reson Med. 2021 Jun 25.  View on PubMed
  5. Lv X, Walton JH, Druga E, Wang F, Aguilar A, McKnelly T, Nazaryan R, Liu FL, Wu L, Shenderova O, Vigneron DB, Meriles CA, Reimer JA, Pines A, Ajoy A. Background-free dual-mode optical and 13C magnetic resonance imaging in diamond particles. Proc Natl Acad Sci U S A. 2021 May 25; 118(21).  View on PubMed
  6. Bøgh N, Olin RB, Hansen ES, Gordon JW, Bech SK, Bertelsen LB, Sánchez-Heredia JD, Blicher JU, Østergaard L, Ardenkjær-Larsen JH, Bok RA, Vigneron DB, Laustsen C. Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke. J Cereb Blood Flow Metab. 2021 May 20; 271678X211018317.  View on PubMed
  7. Tang S, Meng MV, Slater JB, Gordon JW, Vigneron DB, Stohr BA, Larson PEZ, Wang ZJ. Metabolic imaging with hyperpolarized 13 C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience. Cancer. 2021 Aug 01; 127(15):2693-2704.  View on PubMed
  8. Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R. Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models. Metabolites. 2021 Feb 26; 11(3).  View on PubMed
  9. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. Tumor Metabolism and Neurocognition in CNS Lymphoma. Neuro Oncol. 2021 Feb 24.  View on PubMed
  10. Autry AW, Park I, Kline C, Chen HY, Gordon JW, Raber S, Hoffman C, Kim Y, Okamoto K, Vigneron DB, Lupo JM, Prados M, Li Y, Xu D, Mueller S. Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers. AJNR Am J Neuroradiol. 2021 01; 42(1):178-184.  View on PubMed
  11. Walker CM, Gordon JW, Xu Z, Michel KA, Li L, Larson PEZ, Vigneron DB, Bankson JA. Slice profile effects on quantitative analysis of hyperpolarized pyruvate. NMR Biomed. 2020 10; 33(10):e4373.  View on PubMed
  12. Ohliger MA, Gordon JW, Carvajal L, Larson PEZ, Ou JJ, Agarwal S, Zhu Z, Vigneron DB, von Morze C. 55 Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized 13 C MRI. Magn Reson Med. 2021 01; 85(1):518-530.  View on PubMed
  13. Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ. A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI. Magn Reson Med. 2020 12; 84(6):2943-2952.  View on PubMed
  14. Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y. Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. Neuroimage Clin. 2020; 27:102323.  View on PubMed
  15. Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB. Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI. Magn Reson Med. 2020 12; 84(6):3351-3365.  View on PubMed
  16. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J. Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model. Int J Radiat Oncol Biol Phys. 2020 08 01; 107(5):887-896.  View on PubMed
  17. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D. Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco. NMR Biomed. 2021 05; 34(5):e4280.  View on PubMed
  18. Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J. Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers (Basel). 2020 Feb 26; 12(3).  View on PubMed
  19. Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ. A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020 09; 84(3):1113-1125.  View on PubMed
  20. Milshteyn E, Reed GD, Gordon JW, von Morze C, Cao P, Tang S, Leynes AP, Larson PEZ, Vigneron DB. Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence. J Magn Reson. 2020 03; 312:106691.  View on PubMed

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