UCSF at AACR 2024
Each year UCSF Helen Diller Family Comprehensive Cancer Center members, physicians, faculty members, and advocates participate in the Annual Meeting of the American Association for Cancer Research (AACR).
The theme of this year’s conference, “Inspiring Science, Fueling Progress, Revolutionizing Care,” showcases the latest advances in the biology, prevention, detection, diagnosis, and treatment of cancer as well as state-of-the-art concepts and technologies shaping cancer research today. The gathering brings together scientists, clinicians, health care professionals, survivors, and patients.
Honors and Awards
AACR Recognizes 2023-2024 Research Grantees
- Paola Betancur, PhD, UCSF
2024 Breast Cancer Research Foundation-AACR Career Development Award to Promote Diversity and Inclusion
“A genomic insertion variant activates immune escape in breast cancer” - Zulekha A. Qadeer, PhD, UCSF
2023 AACR-Sontag Foundation Brain Cancer Research Fellowship
“Targeting epigenetic drivers in group 3 medulloblastoma”
UCSF in the News
- Advances in Targeted Therapy, Treatment Disparities Among Cancer Conference Talks UCSF.edu | April 5, 2024
- ImPrint Identifies Patients With Breast Cancer Likely to Respond to Neoadjuvant Immunotherapy MDEdge.com April 10, 2024
- After approvals for one of cancer's 'undruggable' targets, research into new KRAS therapies booms: #AACR24 endpts.com April 11, 2024
- Agendia's ImPrint Headed for Prospective Validation as Tool for Guiding Breast Cancer Immunotherapy Precision Medicine Online April 11, 2024
- Advances in Targeted Therapy, Treatment Disparities Among Cancer Conference Talks OncLive April 22, 2024
Friday, April 5
- 3:00 p.m. – 4:30 p.m. | Educational Session: Measuring Structural and Social Determinants of Health in Cancer Research
Salma Shariff-Marco, PhD, MPH, a social and behavioral scientist and UCSF associate adjunct professor, serves as chairperson of this session and also presents “Characterizing social and built environments in cancer epidemiology cohorts: Geospatial data and methods.”
Saturday, April 6
- 2:30 p.m. – 4:00 p.m. | Educational Session: “Genetic Ancestry, Tumor Subtype and Somatic Genomic Landscape”
Elad Ziv, MD, an internal medicine specialist and UCSF professor of Medicine, presents “Genetic ancestry and somatic mutational landscape in >40,000 breast cancer patients.”
Sunday, April 7
- 1:00 p.m. – 2:30 p.m. | Major Symposium: Socioeconomic Contributions to Cancer Health Disparities
Scarlett Gomez, MPH, PhD, an epidemiologist and UCSF professor of Epidemiology and Biostatistics, serves as chairperson for the symposium and also presents “Multi-level socioeconomic contributions to cancer health disparities from concept to measurement to practice."
- 3:00 p.m. – 5:00 p.m. | Mini-Symposium: CL01.03 - Biomarkers Predictive of Therapeutic Benefit
Denise Wolf, PhD, UCSF Department of Laboratory Medicine, is the presenter for “Immune subtyping identifies a subset of HR+HER2- early-stage breast cancer patients with a very high likelihood of response to neoadjuvant immunotherapy (IO): Results from 5 IO arms of the I-SPY2 TRIAL.”
- 6:50 – 7:40 p.m. | Artificial Intelligence for Research Enhancement in Population Sciences: A Population Sciences Working Group Town Hall Meeting
Yulin Hswen, PsyD, MPH, is a computational epidemiologist and assistant professor in the Department of Epidemiology and Biostatistics and the Bakar Computational Health Sciences Institute at UCSF, where she leads research on using artificial intelligence to uncover social patterns of disease and the transmission of information through social networks.
Monday, April 8
- 10:15 a.m. – 12:00 a.m. | Presidential Select Symposium: Cancer Immunotherapy – Where Do We Go from Here?
Alexander Marson, MD, PhD, UCSF professor of Medicine and director of the Gladstone-UCSF Institute of Genomic Immunology, will present “Decoding and reprogramming T-cell circuits with CRISPR” at the presidential select symposium.
- 10:15 a.m. – 12:15 p.m. | Clinical Trials Plenary Session: Advances in Targeted Therapy
Hope Rugo, MD, a medical oncologist, Winterhof Family Endowed Professorship in Breast Cancer, and director of Breast Oncology Trials and Clinical Education at UCSF, will be a discussant for two UK trials called the Partner trials.
- 10:15 a.m. – 11:45 a.m. | Major Symposium: Advances in Pediatric Cancer: Mechanisms, Vulnerabilities, and TranslationAlejandro Sweet-Cordero, MD, UCSF chief of Pediatric Oncology, presents “Identification of novel osteosarcoma subtypes based on epigenetic and genomic analysis.”
Sweet-Cordero also will serve as chairperson for Town Hall Meeting: Then and Now: Updates in Pediatric Cancer Predisposition— A Pediatric Cancer Working Group Town Hall Meeting on Sunday, April 7, from 6:00 p.m. – 8:30 p.m. He is chair of AACR’s Pediatric Cancer Working Group (PCWG).
- 2:30 p.m. - 4:30 p.m. | Mini-symposium: Novel Molecular Targets and Biomarkers
Darwin Kwok, MS, cancer immunotherapy Ph.D. candidate at UCSF, presents “Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types.”
- 5:00 p.m. – 5:45 p.m. | “Meet-the-Expert” session
Jennifer Ruben Grandis, MD, an otolaryngologist and associate vice chancellor for clinical and translational research at UCSF, leads a “meet the expert session” on the topic of “Identifying and Measuring Gender Inequities in Science and Medicine.”
Tuesday, April 9
- 10:15 a.m. – 11:45 a.m. | Major Symposium: Health Behavior Practices after Cancer Diagnosis to Deter Cancer Progression and Death: Evidence, Gaps, and Solutions
June Chan, ScD, the Steven and Christine Burd-Safeway Distinguished Professor of Epidemiology and Biostatistics at UCSF, serves as chairperson for this symposium and presents “Does exercise or fitness deter cancer progression after diagnosis?”
- 12:30 p.m. – 2:00 p.m. | Advances in Diagnostics and Therapeutics session: KRAS: Broadening the Attack Beyond G12C with Small Molecules and Immuno-Oncology
Kevin M. Shokat, PhD, UCSF professor of Cellular and Molecular Pharmacology and AACR Academy Fellow, chairs this session and presents “Expanding K-Ras covalent chemistry for targeting K-Ras (G12D).”
- 12:30 p.m. – 2:00 p.m. | Major Symposium: Discovering and Broadening the Therapeutic Modalities of Immune Therapy
Matthew Krummel, PhD, professor of Pathology and Robert E. Smith Endowed Chair in Experimental Pathology at UCSF, presents “Using archetypes and machine learning to discover novel immune pathways for tumor elimination.”
- 12:30 p.m. – 2:00 p.m. | Advances in Prevention Research session: “From Precursors to Prevention: How Research into Cancer Precursor Lesions Creates Prevention Opportunities”Boris Bastian, MD, PhD a dermatologist and the Gerson and Barbara Bass Bakar Distinguished Professor in Cancer Research at UCSF, presents “When you come to a fork in the road, take it: Navigating the diverse evolutionary paths from precursor lesions to melanomas.”
- 6:00 p.m. – 8:00 p.m. | Town Hall Meeting: Advancing Radiation Oncology with Artificial Intelligence: A Radiation Science and Medicine Working Group Town Hall Meeting
Gilmer Valdes, PhD, assistant professor in the UCSF department of Radiation Oncology, is an invited speaker presenting “Causal Targeted Machine Learning for Real-World Evidence Generation in Oncology: Assessing Causal Effects of Radiation Toxicity on Overall Survival in Stage III Non-Small Cell Lung Cancer.”
Wednesday, April 10
- 10:15 a.m. – 11:45 a.m. | Major Symposium: Cancer Metabolism Across Scales: From Organelles to Organisms
Rushika Perera, PhD, UCSF associate professor of Anatomy, presents “Lysosome dependent metabolic adaptation in pancreatic cancer.”
YouTube Playlist: Deeper Dive into AACR Presentations
Featured videos of presenters and attendees
- Salma Shariff-Marco, PhD, MPH | Structural and Social Determinants of Health
- Darwin Kwok, MS | Novel Molecular Targets
- Jennifer Grandis, MD | Gender Inequities in Science and Medicine
- Michelle Arkin, PhD | Chemistry and Cancer Drug Discovery
- Alex Marson, MD, PhD | Decoding and reprogramming T cell circuits with CRISPR
- Hope Rugo, MD | Clinical Trials Discussant on "Advanced in Targeted Therapy"
- Scarlett Gomez, PhD, MPH | Preview of Disparities Sessions
- Alejandro Sweet-Cordero, MD | Osteosarcoma
- June Chan, ScD | Highlights in Population Science Presentations
- Gilmer Valdes, PhD | Advancing Radiation Oncology with AI
- Yulin Hswen, ScD, MPH | AI for Research Enhancement in Population Sciences
Highlights on Twitter
✨Highlighting a @CD_AACR Special Issue Commentary for #AACR24 - Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers by @BivonaTrever https://t.co/Rr0zI35xTH @UCSF @UCSFCancer pic.twitter.com/s5seZy9DcP
— Elizabeth McKenna (@ElizSMcKenna) April 8, 2024
In case you needed any more data on the value of exercise @JuneChanScD sharing that cancer-related pathways down regulated in men engaging in more vigorous exercise #AACR24 #AACR2024 pic.twitter.com/4ch2A1QljW
— Stacey Tinianov (she/her) MPH, BCPA (@coffeemommy) April 9, 2024
Out now with the #AACR24 late-breaking session LBMS01:
— Cancer Immunology Research (@CIR_AACR) April 8, 2024
PVRL2 Suppresses Antitumor Immunity Through PVRIG- and TIGIT-Independent Pathways, by @RobertBlelloch, @JiulingYang4 et al.https://t.co/w3tkUaMZZ7@UCSF @UCSFstemcell @UCSFUrology @UCSFCancer @AACR pic.twitter.com/bfhRHztUqK
It was truly an honor to present at the AACR Annual Meeting yesterday. Very grateful to #AACR24 organizers, my mentor @RobertBlelloch, and our incredible collaborators. Our new publication is now online in @CIR_AACR! For more details on the rising star immune checkpoint, PVRL2,⬇️ pic.twitter.com/rsvBCIRY2J
— Jiuling Yang (@JiulingYang4) April 9, 2024
At #AACR24, I presented early promising data from Innovative Cellular Therapeutics with the GCC19 coupled #CART approach. In pre-treated advanced MSS #CRC there were 2 partial responses in the first 4 patients. There is hope for #IO in this devastating disease! https://t.co/54dicPgTVi pic.twitter.com/6UwgBdj4RA
— Bridget Keenan MD PhD (@bridgetMDPhD) April 10, 2024
Nice talk by @MaxKrummel on the frontier of immunotherapy and machine learning at #AACR24. The potential for discovering new immune pathways to combat tumors is immense and underscores the importance of integrating technology in biomedical research. For those intrigued by the…
— Raffaele Di Giacomo, PhD (@sciqst) April 9, 2024
It’s a great honor to chair today’s New Drugs on the Horizon session at #AACR24 together with @MichelleArkin. We are looking forward to a mix of modalities comprising reversible & covalent inhibitors, a non-degrading glue and a radiopharmaceutical drug. Join us in ballroom 20 C. pic.twitter.com/j6LUsvE5P5
— Ingo Hartung (@HartungIngo) April 8, 2024
I am grateful to this panel of experts for sharing their visions for the future of cancer immunotherapy. #AACR24 @AACR https://t.co/XjTeuYUzW1
— AACR President Patricia M. LoRusso (@AACRPres) April 8, 2024