Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. Read more about Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.
Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. Read more about Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair.
The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. Read more about The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
Revisiting the "Art of the Chemical Probe". Read more about Revisiting the "Art of the Chemical Probe".
CRISPR Approaches to Small Molecule Target Identification. Read more about CRISPR Approaches to Small Molecule Target Identification.
Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. Read more about Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. Read more about CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine.
The Promise and Challenge of In Vivo Delivery for Genome Therapeutics. Read more about The Promise and Challenge of In Vivo Delivery for Genome Therapeutics.
Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. Read more about Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. Read more about Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.
