Substrate analog studies of the ?-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Read more about Substrate analog studies of the ?-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors. Read more about Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily. Read more about Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily.
Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes. Read more about Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes.
Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent. Read more about Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent.
Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Read more about Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis.
Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Read more about Development of an optimized activatable MMP-14 targeted SPECT imaging probe.
Using specificity to strategically target proteases. Read more about Using specificity to strategically target proteases.
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Read more about Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.
Recent developments in the identification of novel oxazolidinone antibacterial agents. Read more about Recent developments in the identification of novel oxazolidinone antibacterial agents.
