An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Read more about An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Read more about The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Read more about The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins. Read more about Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins.
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Read more about Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.
The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h. Read more about The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h.
Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Read more about Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Read more about Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.
A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Read more about A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool. Read more about cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool.
