LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Read more about LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Read more about Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.
Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Read more about Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Read more about Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Impaired Th2 subset development in the absence of CD4. Read more about Impaired Th2 subset development in the absence of CD4.
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Read more about IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Read more about Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Read more about Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.
alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Read more about alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Read more about CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
