Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Read more about Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. Read more about First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation.
Drugging the Next Undruggable KRAS Allele-Gly12Asp. Read more about Drugging the Next Undruggable KRAS Allele-Gly12Asp.
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens. Read more about Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells. Read more about Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells.
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. Read more about Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Read more about Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. Read more about Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. Read more about Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. Read more about Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
