Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. Read more about Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Read more about Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. Read more about Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. Read more about Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). Read more about Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
Predicting and improving the membrane permeability of peptidic small molecules. Read more about Predicting and improving the membrane permeability of peptidic small molecules.
Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase. Read more about Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.
Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes. Read more about Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes.
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Read more about Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Irreversible Nek2 kinase inhibitors with cellular activity. Read more about Irreversible Nek2 kinase inhibitors with cellular activity.
