Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. Read more about Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. Read more about Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.
An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells. Read more about An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells.
Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways. Read more about Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways.
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. Read more about Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
Electrophilic fragment-based design of reversible covalent kinase inhibitors. Read more about Electrophilic fragment-based design of reversible covalent kinase inhibitors.
Ordering a dynamic protein via a small-molecule stabilizer. Read more about Ordering a dynamic protein via a small-molecule stabilizer.
Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding. Read more about Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding.
Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. Read more about Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.
Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. Read more about Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.
