The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Read more about The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Read more about Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Read more about Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Read more about Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Read more about Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Read more about PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Read more about A framework for understanding and targeting residual disease in oncogene-driven solid cancers.
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Read more about Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Read more about PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Read more about Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.
