Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. Read more about Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy. Read more about Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Read more about Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Read more about UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer. Read more about TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer.
Nucleic acid targeting: towards personalized therapy for head and neck cancer. Read more about Nucleic acid targeting: towards personalized therapy for head and neck cancer.
RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Read more about RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.
TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. Read more about TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair.
Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Read more about Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death.
Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Read more about Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.
