Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Read more about Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.
ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Read more about ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth.
Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Read more about Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.
Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. Read more about Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.
Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation. Read more about Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation.
Adaptive stress signaling in targeted cancer therapy resistance. Read more about Adaptive stress signaling in targeted cancer therapy resistance.
Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Read more about Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.
Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. Read more about Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.
Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model. Read more about Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model.
Alternative splicing in cancer: implications for biology and therapy. Read more about Alternative splicing in cancer: implications for biology and therapy.
