Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity. Read more about Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Read more about A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
Ancient transcriptional regulators can easily evolve new pair-wise cooperativity. Read more about Ancient transcriptional regulators can easily evolve new pair-wise cooperativity.
Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. Read more about Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Read more about Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator. Read more about Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator.
B cell peripheral tolerance is promoted by cathepsin B protease. Read more about B cell peripheral tolerance is promoted by cathepsin B protease.
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Read more about Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. Read more about TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Read more about Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
