Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRASG12D.

Budai B, Vaupel A, Dickson CJ, Beyer KS, Guthy DA, Ostermann N, McGregor LM, De Kanter R, Weiss A, Linder M, Sager E, Bomio-Confaglia C, Proctor R, Leblanc C, Yuan J, Cotesta S, Wilcken R, Danilack AD, Garcia F, Rogemoser P, Kazic-Legueux M, Zhang Z, Zheng Q, Shokat KM, Brachmann SM, Ehmke V