Over the past decade, my laboratory has pioneered multiple approaches for perturbing, quantifying, and interpreting cancer heterogeneity in normal and diseased tissues. We investigate phenotypic heterogeneity, whether arising from microenvironment, epigenetic or genetic sources, and its impact on cancer evolution, drug tolerance and effective treatment strategies.
April 1, 2020 - March 31, 2025 - Scalable Image-Based Approach for Profiling and Annotating Very Large Compound Libraries” , co-PI . Sponsor: NIH/NCI, Sponsor Award ID: 2R01 CA184984-06A1
September 1, 2019 - August 31, 2024 - A drug discovery paradigm for fast-tracking adaptations to high altitude , co-PI . Sponsor: DARPA, Sponsor Award ID: Panacea
September 1, 2017 - June 30, 2021 - Reverse-engineering mechanisms of neural circuit wiring in the fly visual system , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01EY028205
February 1, 2015 - January 31, 2020 - Systems-level role of GSK3 in colonic epithelium homeostasis and drug resistance , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM112690
University of Pennsylvania, BA, 1985, Mathematics
University of California, San Diego, MA, 1986, Mathematics
University of California, San Diego, PhD, 1990, Mathematics (Advisor: Richard Hamilton)