Research Summary

I am an Associate Professor in the UCSF Department of Microbiology & Immunology, and a Leukemia and Lymphoma Society Scholar. My laboratory in the Sandler Asthma Basic Research Center at the UCSF Parnassus campus studies the molecular basis of immune cell programming, with a particular focus on post-transcriptional regulation of gene expression in T cells. My laboratory is part of the Sandler Asthma Basic Research Center (SABRe), an investigative unit dedicated to basic discovery in asthma research. The SABRe Center’s advanced technology cores and connections with clinical research centers create an advantageous environment for marrying basic discoveries and technological innovation in RNA biology with translational approaches to apply fundamental research to advance the prevention and treatment of human disease. Our connections with other HDFCCC investigators have led to synergistic collaborations and joint funding to investigate miRNA homeostasis and function in cancer and immunity.

Research Funding

  • July 1, 2020 - June 30, 2025 - Predoctrol Training in Biomedical Sciences, Principal Investigator. Sponsor: NIH, Sponsor Award ID: T32GM136547
  • August 15, 2012 - July 31, 2024 - Exploring the biology of persistent type 2 airway niches in asthma, Leader, Project 2: MicroRNA networks in persistent type 2 airway niches in asthma. Sponsor: NIH, Sponsor Award ID: 2P01HL107202-06A1
  • May 10, 2018 - April 30, 2020 - Global analysis of T cell post-transcriptional regulatory elements, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21AI128047
  • August 1, 2011 - March 31, 2020 - MicroRNA directed pathway discovery in helper T cell driven airway inflammation, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01HL109102

Education

Virginia Tech (Blacksburg, VA), B.S., 1992-1996, Biochemistry
University of California, San Francisco, Ph.D., 1996-2001, Biomedical Sciences
Immune Disease Institute, Harvard Medical School, 2001-2007, Immunology

Honors & Awards

  • 1997 - 2001
    Howard Hughes Medical Institute Predoctoral Fellowship
  • 2001 - 2004
    Damon Runyon Cancer Research Fund Postdoctoral Fellowship
  • 2005 - 2007
    Leukemia and Lymphoma Society Special Fellow
  • 2006 - 2012
    Burroughs Wellcome Career Award in Biomedical Sciences
  • 2007
    International Cytokine Society Outstanding Postdoctoral Fellow
  • 2009 - 2012
    Dana Foundation Human Immunology Scholar
  • 2012
    American Association of Immunologists Young Investigator Travel Award
  • 2012 -
    Leukemia & Lymphoma Society Scholar

Selected Publications

  1. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152.  View on PubMed
  2. Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23.  View on PubMed
  3. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Mar 26.  View on PubMed
  4. Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG. Epithelial miR-141 regulates IL-13-induced airway mucus production. JCI Insight. 2021 03 08; 6(5).  View on PubMed
  5. Taylor KE, Ansel KM, Marson A, Criswell LA, Farh KK. PICS2: Next-generation fine mapping via probabilistic identification of causal SNPs. Bioinformatics. 2021 Feb 24.  View on PubMed
  6. Wigton EJ, Ansel KM. Noncoding RNAs in B cell responses. RNA Biol. 2021 05; 18(5):633-639.  View on PubMed
  7. Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14.  View on PubMed
  8. Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, Koralov SB. miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling. Cell Rep. 2020 12 01; 33(9):108436.  View on PubMed
  9. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 09 04; 11(1):4499.  View on PubMed
  10. Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV. An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020 08; 50(8):904-914.  View on PubMed
  11. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 06 19; 11(1):3126.  View on PubMed
  12. Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ, National Heart, Lung, and Blood Institute’s ”AsthmaNet“ . Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020 11; 146(5):1016-1026.  View on PubMed
  13. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M, Future Immunology Consortium . Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell. 2019 Dec 12; 179(7):1441-1445.  View on PubMed
  14. Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW. RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Cell Rep. 2019 09 10; 28(11):2795-2806.e3.  View on PubMed
  15. Gagnon JD, Ansel KM. MicroRNA regulation of CD8+ T cell responses. Noncoding RNA Investig. 2019 Aug; 3.  View on PubMed
  16. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4.  View on PubMed
  17. Wigton EJ, DeFranco AL, Ansel KM. Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. Immunohorizons. 2019 08 19; 3(8):389-401.  View on PubMed
  18. Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM. A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization. Genome Res. 2019 06; 29(6):896-906.  View on PubMed
  19. Das S, Extracellular RNA Communication Consortium , Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 04 04; 177(2):231-242.  View on PubMed
  20. Pua HH, Happ HC, Gray CJ, Mar DJ, Chiou NT, Hesse LE, Ansel KM. Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses. Cell Rep. 2019 01 22; 26(4):933-944.e4.  View on PubMed

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