Research Summary

I am an Associate Professor in the UCSF Department of Microbiology & Immunology, and a Leukemia and Lymphoma Society Scholar. My laboratory in the Sandler Asthma Basic Research Center at the UCSF Parnassus campus studies the molecular basis of immune cell programming, with a particular focus on post-transcriptional regulation of gene expression in T cells. My laboratory is part of the Sandler Asthma Basic Research Center (SABRe), an investigative unit dedicated to basic discovery in asthma research. The SABRe Center’s advanced technology cores and connections with clinical research centers create an advantageous environment for marrying basic discoveries and technological innovation in RNA biology with translational approaches to apply fundamental research to advance the prevention and treatment of human disease. Our connections with other HDFCCC investigators have led to synergistic collaborations and joint funding to investigate miRNA homeostasis and function in cancer and immunity.

Research Funding

  • July 1, 2020 - June 30, 2025 - Predoctrol Training in Biomedical Sciences, Principal Investigator. Sponsor: NIH, Sponsor Award ID: T32GM136547
  • August 15, 2012 - July 31, 2024 - Exploring the biology of persistent type 2 airway niches in asthma, Leader, Project 2: MicroRNA networks in persistent type 2 airway niches in asthma. Sponsor: NIH, Sponsor Award ID: 2P01HL107202-06A1
  • May 10, 2018 - April 30, 2020 - Global analysis of T cell post-transcriptional regulatory elements, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21AI128047
  • August 1, 2011 - March 31, 2020 - MicroRNA directed pathway discovery in helper T cell driven airway inflammation, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01HL109102

Education

Virginia Tech (Blacksburg, VA), B.S., 1992-1996, Biochemistry
University of California, San Francisco, Ph.D., 1996-2001, Biomedical Sciences
Immune Disease Institute, Harvard Medical School, 2001-2007, Immunology

Honors & Awards

  • 1997 - 2001
    Howard Hughes Medical Institute Predoctoral Fellowship
  • 2001 - 2004
    Damon Runyon Cancer Research Fund Postdoctoral Fellowship
  • 2005 - 2007
    Leukemia and Lymphoma Society Special Fellow
  • 2006 - 2012
    Burroughs Wellcome Career Award in Biomedical Sciences
  • 2007
    International Cytokine Society Outstanding Postdoctoral Fellow
  • 2009 - 2012
    Dana Foundation Human Immunology Scholar
  • 2012
    American Association of Immunologists Young Investigator Travel Award
  • 2012 -
    Leukemia & Lymphoma Society Scholar

Selected Publications

  1. Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.  View on PubMed
  2. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.  View on PubMed
  3. Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG Epithelial miR-141 regulates IL-13-induced airway mucus production.  View on PubMed
  4. Taylor KE, Ansel KM, Marson A, Criswell LA, Farh KK PICS2: Next-generation fine mapping via probabilistic identification of causal SNPs.  View on PubMed
  5. Wigton EJ, Ansel KM Noncoding RNAs in B cell responses.  View on PubMed
  6. Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.  View on PubMed
  7. Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, Koralov SB miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.  View on PubMed
  8. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.  View on PubMed
  9. Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells.  View on PubMed
  10. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.  View on PubMed
  11. Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma.  View on PubMed
  12. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M Universal Principled Review: A Community-Driven Method to Improve Peer Review.  View on PubMed
  13. Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.  View on PubMed
  14. Gagnon JD, Ansel KM MicroRNA regulation of CD8+ T cell responses.  View on PubMed
  15. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.  View on PubMed
  16. Wigton EJ, DeFranco AL, Ansel KM Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.  View on PubMed
  17. Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.  View on PubMed
  18. Das S, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.  View on PubMed
  19. Pua HH, Happ HC, Gray CJ, Mar DJ, Chiou NT, Hesse LE, Ansel KM Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses.  View on PubMed
  20. Chiou NT, Kageyama R, Ansel KM Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.  View on PubMed

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