Research Summary
Dr. Arjomandi is Professor of Medicine in the Divisions of Pulmonary, Critical Care, Allergy, and Sleep Medicine and Occupational and Environmental Medicine at UCSF with a joint appointment at San Francisco Veterans Affairs Medical Center. He is Director of the UCSF Human Exposure Laboratory at San Francisco General Hospital, Director of Environmental Medicine Clinic at San Francisco VA Medical Center, Site Director for the VA Airborne Hazard Exposure Study Center of Excellence at San Francisco VA, and an investigator at the UCSF Center for Tobacco Control Research and Education.
Dr. Arjomandi received his bachelor degree in molecular biology from University of California San Diego in 1991, and his MD degree from Stanford University School of Medicine in 1996. He completed his residency in Internal Medicine at UCLA Medical Center (1999) and his fellowship in Pulmonary and Critical Care Medicine at UCSF (2003) before obtaining an NIH/NHLBI Mentored Patient-oriented Career Development Award (K23) and joining the faculty at UCSF. In 2008, He also obtained a joint appointment at the San Francisco VA Medical Center.
Research Interests
The lung is constantly exposed to various environmental pollutants, allergens, and toxins, which interact with airways and alveoli and result in inflammation, injury, and disease. My laboratory primary research interest has been centered on the paradigm that respiratory exposures to pollutants and toxicants contribute to development and progression of chronic lung diseases, and may further yield systemic effects well beyond lungs. Under this paradigm, my research activities have focused on understanding the physiologic and immunologic mechanisms via which environmental exposures contribute to chronic lung diseases and how knowledge of these mechanisms could be translated to ways to better define, prognosticate, and manage disease burden at both individual and societal levels.
I have dedicated my efforts to (1) investigate the biology of airway immune cells using inhalational exposure to ozone in humans as a model of lung injury simulating exacerbation in chronic lung disease, and (2) characterize the early cardiopulmonary changes due to exposure to tobacco smoke and the pathophysiology and biology associated with those changes.
Research Funding
July 1, 2020 - June 30, 2023 - Occult Cardiovascular Disease with Chronic Exposure to Secondhand Tobacco Smoke, PI. Sponsor: Flight Attendant Medical Research Institute (FAMRI), Sponsor Award ID: SFGH Foundation
July 1, 2017 - June 30, 2022 - Circulating Tumor DNA in Patients at High Risk for Lung Cancer, PI. Sponsor: Guardant Health, Inc., Sponsor Award ID: NCIRE-2062
April 1, 2019 - March 31, 2022 - Characterization of Innate Immunity in Pollution-induced Exacerbation in Chronic Obstructive Pulmonary Disease (CO3PD Study), PI. Sponsor: California TRDRP, Sponsor Award ID: T29IR0715
March 1, 2020 - February 28, 2022 - Lung Macrophage Populations and Functions in COPD-Susceptible Smokers (Pre-COPD Study), PI. Sponsor: Department of Defense, Sponsor Award ID: W81XWH-20-1-0158
Education
University of California, San Diego, BA, 06/1991, Molecular Biology
Stanford University, MD, 06/1996, MD Program
University of California, Los Angeles, Residency, 06/1999, Internal Medicine
University of California, San Francisco Fellowship, 06/2003, Pulmonary & Critical Care Medicine
University of California, San Francisco, Certificate, 06/2003, Advanced Training in Clinical Research
Veterans Affairs Cooperative Study Program, Certificate, 08/2009, Clinical Trial Design Course
University of California, San Francisco, Certificate, 05/2010, Mentor Development Program
The Jackson Laboratories (NIH/NHLBI), Certificate, 10/2010, Genetic Approaches to Complex Heart, Lung and Blood Diseases
University of California, San Francisco, CA, 2018, Diversity, Equity, and Inclusion Champion Training