Research Funding

  • June 1, 2016 - May 31, 2021 - Roles for Intracellular pH Dynamics in Cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA197855
  • July 1, 2015 - June 30, 2019 - Regulation of Epithelial Plasticity, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM116384
  • July 1, 2013 - June 30, 2015 - Retention of somatic mutations in cancers by changes in pH sensing, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA178706
  • August 13, 2009 - May 31, 2015 - Mechanisms of Receptor Regulated Na+-H+ Exchange, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM047413

Education

University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy

Honors & Awards

  • 1985-87
    NIH Individual NRSA Postdoctoral Fellowship
  • 1986
    Joseph P. Healy Research Award, University of Massachusetts
  • 1995-2000
    Established Investigator, American Heart Association
  • 1998-present
    Editorial Board, American Journal of Physiology: Cell Physiology
  • 1998-1999
    American Heart Association, National Review Committee for Transport and Metabolism
  • 1998
    Innovation in Basic Sciences Award, UCSF
  • 2000-2002
    American Heart Association, Co-chair National Review Committee for Transport and Metabolism
  • 2001/2003
    Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
  • 2001-2003
    Member, NIH CDF3 Study Section
  • 2003-present
    Editorial Board, Journal of Biological Chemistry
  • 2005
    Sandler Program Integrative Award

Selected Publications

  1. Sesanto R, Kuehn JF, Barber DL, White KA. Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate. Biochemistry. 2021 Jun 29; 60(25):1983-1994.  View on PubMed
  2. Manoli SS, Kisor K, Webb BA, Barber DL. Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells. Am J Physiol Cell Physiol. 2021 07 01; 321(1):C147-C157.  View on PubMed
  3. Webb BA, Aloisio FM, Charafeddine RA, Cook J, Wittmann T, Barber DL. pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells. Mol Biol Cell. 2021 01 15; 32(2):131-142.  View on PubMed
  4. Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. Biochem J. 2020 08 28; 477(16):2999-3018.  View on PubMed
  5. Liu Y, White KA, Barber DL. Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective. Front Oncol. 2020; 10:1401.  View on PubMed
  6. Barber DL, Trepat X. Editorial overview: Cell dynamics: Integrating cell dynamics across scales. Curr Opin Cell Biol. 2020 10; 66:130-132.  View on PubMed
  7. Bradley Webb, Anne Dosey, Torsten Wittmann, Justin Kollmann, Diane Barber. Filament assembly by the liver phosphofructokinase-1, the “gatekeeper” of glycolysis. The FASEB Journal. 2020 Apr 1; 34(S1):1-1.  View on PubMed
  8. White KA, Kisor K, Barber DL. Intracellular pH dynamics and charge-changing somatic mutations in cancer. Cancer Metastasis Rev. 2019 06; 38(1-2):17-24.  View on PubMed
  9. Benitez M, Tatapudy S, Liu Y, Barber DL, Nystul TG. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Dev Biol. 2019 08 15; 452(2):127-133.  View on PubMed
  10. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 05 31; 294(22):8779-8790.  View on PubMed
  11. White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. β-Catenin is a pH sensor with decreased stability at higher intracellular pH. J Cell Biol. 2018 11 05; 217(11):3965-3976.  View on PubMed
  12. Rana MK, Aloisio FM, Choi C, Barber DL. Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. Mol Biol Cell. 2018 06 15; 29(12):1465-1475.  View on PubMed
  13. Bradley Webb, Annie Dosey, Torsten Wittmann, Justin Kollman, Diane Barber. The Glycolytic Enzyme Phosphofructokinase-1 Assembles into Filaments. Biophysical Journal. 2018 Feb 1; 114(3):228a.  View on PubMed
  14. Tatapudy S, Aloisio F, Barber D, Nystul T. Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Rep. 2017 12; 18(12):2105-2118.  View on PubMed
  15. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 09 27; 6.  View on PubMed
  16. White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. Sci Signal. 2017 Sep 05; 10(495).  View on PubMed
  17. Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber DL, Hernandez RD. Prominent features of the amino acid mutation landscape in cancer. PLoS One. 2017; 12(8):e0183273.  View on PubMed
  18. Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL. The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017 08 07; 216(8):2305-2313.  View on PubMed
  19. White KA, Grillo-Hill BK, Barber DL. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci. 2017 02 15; 130(4):663-669.  View on PubMed
  20. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber DL, Nystul TG. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol. 2016 Nov 07; 215(3):345-355.  View on PubMed

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