Research Funding

  • June 1, 2016 - May 31, 2021 - Roles for Intracellular pH Dynamics in Cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA197855
  • July 1, 2015 - June 30, 2019 - Regulation of Epithelial Plasticity, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM116384
  • July 1, 2013 - June 30, 2015 - Retention of somatic mutations in cancers by changes in pH sensing, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA178706
  • August 13, 2009 - May 31, 2015 - Mechanisms of Receptor Regulated Na+-H+ Exchange, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM047413

Education

University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy

Honors & Awards

  • 1985-87
    NIH Individual NRSA Postdoctoral Fellowship
  • 1986
    Joseph P. Healy Research Award, University of Massachusetts
  • 1995-2000
    Established Investigator, American Heart Association
  • 1998-present
    Editorial Board, American Journal of Physiology: Cell Physiology
  • 1998-1999
    American Heart Association, National Review Committee for Transport and Metabolism
  • 1998
    Innovation in Basic Sciences Award, UCSF
  • 2000-2002
    American Heart Association, Co-chair National Review Committee for Transport and Metabolism
  • 2001/2003
    Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
  • 2001-2003
    Member, NIH CDF3 Study Section
  • 2003-present
    Editorial Board, Journal of Biological Chemistry
  • 2005
    Sandler Program Integrative Award

Selected Publications

  1. Manoli SS, Kisor K, Webb BA, Barber DL Ethyl Isopropyl Amiloride Decreases Oxidative Phosphorylation and Increases Mitochondrial Fusion in Clonal Untransformed and Cancer Cells.  View on PubMed
  2. Webb BA, Aloisio FM, Charafeddine RA, Cook J, Wittmann T, Barber DL pHLARE: A New Biosensor Reveals Decreased Lysosome pH in Cancer Cells.  View on PubMed
  3. Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.  View on PubMed
  4. Liu Y, White KA, Barber DL Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective.  View on PubMed
  5. Barber DL, Trepat X Editorial overview: Cell dynamics: Integrating cell dynamics across scales.  View on PubMed
  6. Bradley Webb, Anne Dosey, Torsten Wittmann, Justin Kollmann, Diane Barber Filament assembly by the liver phosphofructokinase-1, the “gatekeeper” of glycolysis.  View on PubMed
  7. White KA, Kisor K, Barber DL Intracellular pH dynamics and charge-changing somatic mutations in cancer.  View on PubMed
  8. Benitez M, Tatapudy S, Liu Y, Barber DL, Nystul TG Drosophila anion exchanger 2 is required for proper ovary development and oogenesis.  View on PubMed
  9. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.  View on PubMed
  10. White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL ß-Catenin is a pH sensor with decreased stability at higher intracellular pH.  View on PubMed
  11. Rana MK, Aloisio FM, Choi C, Barber DL Formin-dependent TGF-ß signaling for epithelial to mesenchymal transition.  View on PubMed
  12. Bradley Webb, Annie Dosey, Torsten Wittmann, Justin Kollman, Diane Barber The Glycolytic Enzyme Phosphofructokinase-1 Assembles into Filaments.  View on PubMed
  13. Tatapudy S, Aloisio F, Barber D, Nystul T Cell fate decisions: emerging roles for metabolic signals and cell morphology.  View on PubMed
  14. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.  View on PubMed
  15. White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.  View on PubMed
  16. Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber DL, Hernandez RD Prominent features of the amino acid mutation landscape in cancer.  View on PubMed
  17. Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL The glycolytic enzyme phosphofructokinase-1 assembles into filaments.  View on PubMed
  18. White KA, Grillo-Hill BK, Barber DL Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.  View on PubMed
  19. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber DL, Nystul TG Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation.  View on PubMed
  20. Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.  View on PubMed

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