Research Summary

I am Professor of Medicine and Bioengineering & Therapeutic Sciences and Chief of the Division of Clinical Pharmacology at San Francisco General Hospital. With over 500 publications, I am a leading authority on the human pharmacology of nicotine and nicotine addiction. My laboratory also is a leading site for biomarker assessment of tobacco toxicant exposure. I am former president of the Society for Research on Nicotine and Tobacco (SRNT), and the recipient of the Ove Ferno SRNT Award for Clinical Research on Nicotine and Tobacco. I have been a contributing author or editor to six US Surgeon General's Reports on tobacco including the 2010 Surgeon General's Report—How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease.

Research Funding

  • August 15, 2018 - July 31, 2020 - Cigarette Harm Reduction with Scheduled Electronic Cigarette Use, Principal Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: U01DA045519
  • September 1, 1999 - June 30, 2020 - Drug Dependence Clinical Research Program, Co-Principal Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: P30DA012393
  • July 1, 1977 - June 30, 2020 - Clinical Pharmacology, Drug Action and Pharmacogenetics, Co-Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: T32GM007546
  • April 1, 2013 - March 31, 2019 - Technology Innovations for Supporting Health in Alaska Native People, Co-Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL117736


Rennselaer Polytechnic Institute, Troy, NY
University of Rochester School of Medicine, Rochester, NY, MD, 1969, Medicine
Bronx Municipal Hospital Center, Bronx, New York, Intern and Resident, Internal Medicine, 1969-1971
Fellow in Clinical Pharmacology, Department of Medicine, University of California San Francisco, 1971-1972

Honors & Awards

  • Oscar B. Hunter Award
  • Ove Ferno Award
  • 2002
  • UCSF Annual Distinguished Clinical Research Lecturer
  • Rawls Palmer Award for Progress in Medicine
  • Alton Ochsner Award Relating Smoking and Health
  • 1994-2002
  • NIDA Merit Award
  • American Board of Internal Medicine (Diplomate, 1968)
  • American Board of Medical Toxicology
  • American Board of Clinical Pharmacology
  • American Federation for Clinical Research (President 1996 to 1997)
  • American Society for Clinical Inves-tigation
  • American Society of Clinical Pharma-cology and Therapeutics
  • American Society for Pharmacology and Experimental Therapeutics
  • Association of American Physicians
  • Society for Research on Nicotine and Tobacco (President, 1996-1997)

Selected Publications

  1. Estimation of risk of neuropsychiatric adverse events from varenicline, bupropion and nicotine patch versus placebo: secondary analysis of results from the EAGLES trial using Bayes factors.  View on PubMed
  2. Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies.  View on PubMed
  3. Thirdhand smoke associations with the gut microbiomes of infants admitted to a neonatal intensive care unit: An observational study.  View on PubMed
  4. Correlates of the nicotine metabolite ratio in Alaska Native people who smoke cigarettes.  View on PubMed
  5. A Multicenter, Double-blind, Randomized, Placebo-controlled Phase 2b Trial of Cytisinicline in Adult Smokers (The ORCA-1 Trial).  View on PubMed
  6. Prochaska JJ, Vogel EA, Benowitz N Nicotine delivery and cigarette equivalents from vaping a JUULpod.  View on PubMed
  7. Liakoni E, Tyndale RF, Jacob P, Dempsey DA, Addo N, Benowitz NL Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance.  View on PubMed
  8. Rezk-Hanna M, Seals DR, Rossman MJ, Gupta R, Nettle CO, Means A, Dobrin D, Cheng CW, Brecht ML, Mosenifar Z, Araujo JA, Benowitz NL Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping.  View on PubMed
  9. Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE E-Cigarettes and Cardiopulmonary Health.  View on PubMed
  10. Aquilina NJ, Havel CM, Cheung P, Harrison RM, Ho KF, Benowitz NL, Jacob Iii P Ubiquitous atmospheric contamination by tobacco smoke: Nicotine and a new marker for tobacco smoke-derived particulate matter, nicotelline.  View on PubMed
  11. Nollen NL, Ahluwalia JS, Sanderson Cox L, Okuyemi K, Lawrence D, Samuels L, Benowitz NL Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation: Secondary Analysis of the EAGLES Randomized Clinical Trial.  View on PubMed
  12. Denlinger-Apte RL, White CM, Donny EC, Hatsukami DK, Benowitz NL, Carpenter MJ, Smith TT "I actually finally feel like the cigarettes aren't controlling me." - Interviews with participants smoking very low nicotine content cigarettes during a residential study.  View on PubMed
  13. El-Boraie A, Chenoweth MJ, Pouget JG, Benowitz NL, Fukunaga K, Mushiroda T, Kubo M, Nollen NL, Cox LS, Lerman C, Knight J, Tyndale RF Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations.  View on PubMed
  14. Knox M, Skan J, Benowitz NL, Schnellbaecher M, Prochaska JJ Recruitment best practices of a cardiovascular risk reduction randomised control trial in rural Alaska Native communities.  View on PubMed
  15. Benowitz NL, St Helen G, Nardone N, Addo N, Zhang JJ, Harvanko AM, Calfee CS, Jacob P Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.  View on PubMed
  16. Evins AE, West R, Benowitz NL, Russ C, Lawrence D, McRae T, Maravic MC, Heffner JL, Anthenelli RM Efficacy and Safety of Pharmacotherapeutic Smoking Cessation Aids in Schizophrenia Spectrum Disorders: Subgroup Analysis of EAGLES.  View on PubMed
  17. Pulvers K, Nollen NL, Rice M, Schmid CH, Qu K, Benowitz NL, Ahluwalia JS Effect of Pod e-Cigarettes vs Cigarettes on Carcinogen Exposure Among African American and Latinx Smokers: A Randomized Clinical Trial.  View on PubMed
  18. Carroll DM, Cigan S, Ikuemonisan J, Hammonds T, Stepanov I, St Helen G, Benowitz N, Hatsukami DK Relationships Between Race, Gender, and Spot Urine Levels of Biomarkers of Tobacco Exposure Vary Based on How Creatinine Is Handled in Analyses.  View on PubMed
  19. Wakefield MA, Dunstone K, Brennan E, Vittiglia A, Scollo M, Durkin SJ, Hoek J, Thrasher J, Hatsukami D, Benowitz N, Samet JM Australian smokers' experiences and perceptions of recessed and firm filter cigarettes.  View on PubMed
  20. Piper ME, Baker TB, Benowitz NL, Jorenby DE Corrigendum to: Changes in Use Patterns Over 1 Year Among Smokers and Dual Users of Combustible and Electronic Cigarettes.  View on PubMed

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