Research Summary

I am Professor of Medicine and Bioengineering & Therapeutic Sciences and Chief of the Division of Clinical Pharmacology at San Francisco General Hospital. With over 500 publications, I am a leading authority on the human pharmacology of nicotine and nicotine addiction. My laboratory also is a leading site for biomarker assessment of tobacco toxicant exposure. I am former president of the Society for Research on Nicotine and Tobacco (SRNT), and the recipient of the Ove Ferno SRNT Award for Clinical Research on Nicotine and Tobacco. I have been a contributing author or editor to six US Surgeon General's Reports on tobacco including the 2010 Surgeon General's Report—How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease.

Research Funding

  • August 15, 2018 - July 31, 2020 - Cigarette Harm Reduction with Scheduled Electronic Cigarette Use, Principal Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: U01DA045519
  • September 1, 1999 - June 30, 2020 - Drug Dependence Clinical Research Program, Co-Principal Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: P30DA012393
  • July 1, 1977 - June 30, 2020 - Clinical Pharmacology, Drug Action and Pharmacogenetics, Co-Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: T32GM007546
  • April 1, 2013 - March 31, 2019 - Technology Innovations for Supporting Health in Alaska Native People, Co-Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL117736


Rennselaer Polytechnic Institute, Troy, NY
University of Rochester School of Medicine, Rochester, NY, MD, 1969, Medicine
Bronx Municipal Hospital Center, Bronx, New York, Intern and Resident, Internal Medicine, 1969-1971
Fellow in Clinical Pharmacology, Department of Medicine, University of California San Francisco, 1971-1972

Honors & Awards

  • Oscar B. Hunter Award
  • Ove Ferno Award
  • 2002
  • UCSF Annual Distinguished Clinical Research Lecturer
  • Rawls Palmer Award for Progress in Medicine
  • Alton Ochsner Award Relating Smoking and Health
  • 1994-2002
  • NIDA Merit Award
  • American Board of Internal Medicine (Diplomate, 1968)
  • American Board of Medical Toxicology
  • American Board of Clinical Pharmacology
  • American Federation for Clinical Research (President 1996 to 1997)
  • American Society for Clinical Inves-tigation
  • American Society of Clinical Pharma-cology and Therapeutics
  • American Society for Pharmacology and Experimental Therapeutics
  • Association of American Physicians
  • Society for Research on Nicotine and Tobacco (President, 1996-1997)

Selected Publications

  1. Nollen NL, Ahluwalia JS, Sanderson Cox L, Okuyemi K, Lawrence D, Samuels L, Benowitz NL Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation: Secondary Analysis of the EAGLES Randomized Clinical Trial.  View on PubMed
  2. Denlinger-Apte RL, White CM, Donny EC, Hatsukami DK, Benowitz NL, Carpenter MJ, Smith TT "I actually finally feel like the cigarettes aren't controlling me." - Interviews with participants smoking very low nicotine content cigarettes during a residential study.  View on PubMed
  3. El-Boraie A, Chenoweth MJ, Pouget JG, Benowitz NL, Fukunaga K, Mushiroda T, Kubo M, Nollen NL, Cox LS, Lerman C, Knight J, Tyndale RF Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations.  View on PubMed
  4. Knox M, Skan J, Benowitz NL, Schnellbaecher M, Prochaska JJ Recruitment best practices of a cardiovascular risk reduction randomised control trial in rural Alaska Native communities.  View on PubMed
  5. Benowitz NL, St Helen G, Nardone N, Addo N, Zhang JJ, Harvanko AM, Calfee CS, Jacob P Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.  View on PubMed
  6. Evins AE, West R, Benowitz NL, Russ C, Lawrence D, McRae T, Maravic MC, Heffner JL, Anthenelli RM Efficacy and Safety of Pharmacotherapeutic Smoking Cessation Aids in Schizophrenia Spectrum Disorders: Subgroup Analysis of EAGLES.  View on PubMed
  7. Pulvers K, Nollen NL, Rice M, Schmid CH, Qu K, Benowitz NL, Ahluwalia JS Effect of Pod e-Cigarettes vs Cigarettes on Carcinogen Exposure Among African American and Latinx Smokers: A Randomized Clinical Trial.  View on PubMed
  8. Carroll DM, Cigan S, Ikuemonisan J, Hammonds T, Stepanov I, St Helen G, Benowitz N, Hatsukami DK Relationships Between Race, Gender, and Spot Urine Levels of Biomarkers of Tobacco Exposure Vary Based on How Creatinine Is Handled in Analyses.  View on PubMed
  9. Wakefield MA, Dunstone K, Brennan E, Vittiglia A, Scollo M, Durkin SJ, Hoek J, Thrasher J, Hatsukami D, Benowitz N, Samet JM Australian smokers' experiences and perceptions of recessed and firm filter cigarettes.  View on PubMed
  10. Piper ME, Baker TB, Benowitz NL, Jorenby DE Corrigendum to: Changes in Use Patterns Over 1 Year Among Smokers and Dual Users of Combustible and Electronic Cigarettes.  View on PubMed
  11. Chaffee BW, Jacob P, Couch ET, Benowitz NL Exposure to a Tobacco-Specific Carcinogen Among Adolescent Smokeless Tobacco Users in Rural California, United States.  View on PubMed
  12. Piper ME, Baker TB, Mermelstein R, Benowitz N, Jorenby DE Relations among cigarette dependence, e-cigarette dependence, and key dependence criteria among dual users of combustible and e-cigarettes.  View on PubMed
  13. Kovar L, Selzer D, Britz H, Benowitz N, St Helen G, Kohl Y, Bals R, Lehr T Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies.  View on PubMed
  14. Nardone N, Giberson J, Prochaska JJ, Jain S, Benowitz NL A Mobile Health Intervention for Adolescents Exposed to Secondhand Smoke: Pilot Feasibility and Efficacy Study.  View on PubMed
  15. Nardone N, Jain S, Benowitz NL Biomarkers of Exposure to Nicotine and Tobacco-Specific Nitrosamines in Adolescent Blunt Users.  View on PubMed
  16. Liakoni E, Nardone N, St Helen G, Dempsey DA, Tyndale RF, Benowitz NL Effects of Nicotine Metabolic Rate on Cigarette Reinforcement.  View on PubMed
  17. Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices.  View on PubMed
  18. Epperson AE, Crouch M, Skan J, Benowitz NL, Schnellbaecher M, Prochaska JJ Cultural and demographic correlates of dual tobacco use in a sample of Alaska Native adults who smoke cigarettes.  View on PubMed
  19. Benowitz NL, Bernert JT, Foulds J, Hecht SS, Jacob P, Jarvis MJ, Joseph A, Oncken C, Piper ME Biochemical Verification of Tobacco Use and Abstinence: 2019 Update.  View on PubMed
  20. Jacob P, St Helen G, Yu L, Nardone N, Havel C, Cheung P, Benowitz NL Biomarkers of Exposure for Dual Use of Electronic Cigarettes and Combustible Cigarettes: Nicotelline, NNAL, and Total Nicotine Equivalents.  View on PubMed

Go to UCSF Profiles, powered by CTSI