Research Summary

Dr. Bhattacharya is an attending ICU physician at UCSF Medical Center and directs a research laboratory at the Parnassus Heights campus. His lab focuses on lung injury and fibrosis, both major health problems for which effective therapies are limited, and is developing novel approaches to the study of cell-cell interactions in the lung--for example, between immune and structural cells. These interactions drive the development of scarring and progressive loss of lung function and therefore represent an opportunity for discovery of novel therapies.

Research Funding

  • July 1, 2021 - June 30, 2025 - Targeting ATP Receptor P2RX4 for Pulmonary Fibrosis , Principal Investigator . Sponsor: DOD, Sponsor Award ID: W81XWH2110417
  • May 1, 2016 - April 30, 2021 - The Regulation of RhoA Activation in Airway Smooth Muscle , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL131560
  • September 1, 2012 - June 30, 2018 - IQGAP1 In Vascular Barrier Regulation During Acute Lung Injury , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08HL114641
  • January 1, 2011 - December 31, 2011 - Regulation of Endothelial Permeability by Integrin alpha-v beta-3 , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F32HL099026

Education

Harvard University, Cambridge, MA, A.B., 06/1998, Biology and Psychology
Oxford University, Oxford, United Kingdom, M.Sc., 10/1999, Neuroscience
Harvard University, Boston, MA, M.D., 06/2004, Medicine
Johns Hopkins Hospital, Baltimore, MD, Residency, 06/2007, Internal Medicine
University of California, San Francisco, CA, Fellowship, 06/2010, Pulmonary and Critical Care

Honors & Awards

  • 2008-2009
    Will Rogers Institute Fellowship
  • 2000
    American Neurological Association Summer Fellowship
  • 2000
    Pasteur Summer Research Fellowship for Medical Students
  • 1997
    Member, Phi Beta Kappa Society, Harvard College Chapter
  • 1994-1998
    New York State Robert C. Byrd Honors Scholarship
  • 1994-1998
    Dean's List, Harvard College
  • 1995, 97, 98
    John Harvard Scholarship
  • 1996
    Harvard College Scholarship

Selected Publications

  1. Bhattacharyya A, Yadav P, Bhattacharya M. Myeloid-Mesenchymal Crosstalk in Lung Fibrosis. Compr Physiol. 2025 Feb; 15(1):e70004.  View on PubMed
  2. Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M. Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading. bioRxiv. 2024 Jul 31.  View on PubMed
  3. Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis. J Pathol. 2024 05; 263(1):22-31.  View on PubMed
  4. Bhattacharya M. Hard CiDRE revs up macrophage infectivity in COVID-19. Immunity. 2023 08 08; 56(8):1706-1708.  View on PubMed
  5. Bhattacharya M, Ramachandran P. Immunology of human fibrosis. Nat Immunol. 2023 09; 24(9):1423-1433.  View on PubMed
  6. Bhattacharya M. Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19. Am J Respir Cell Mol Biol. 2022 11; 67(5):520-527.  View on PubMed
  7. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887.  View on PubMed
  8. Bhattacharyya A, Boostanpour K, Bouzidi M, Magee L, Chen TY, Wolters R, Torre P, Pillai SK, Bhattacharya M. IL10 trains macrophage profibrotic function after lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L495-L502.  View on PubMed
  9. Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M. Molecular programs of fibrotic change in aging human lung. Nat Commun. 2021 11 02; 12(1):6309.  View on PubMed
  10. Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A. Invariant Natural Killer T cells coordinate removal of senescent cells. Med. 2021 08 13; 2(8):938-950.  View on PubMed
  11. Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M. Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell Rep. 2020 06 30; 31(13):107825.  View on PubMed
  12. Looney AP, Bhattacharya M. Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts. Bio Protoc. 2019 Aug 20; 9(16).  View on PubMed
  13. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019 02; 20(2):163-172.  View on PubMed
  14. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21).  View on PubMed
  15. Bhattacharya M. Could a coffee a day keep the inflammasome away? Sci Transl Med. 2017 02 08; 9(376).  View on PubMed
  16. Bhattacharya M. Mesenchymal metamorphosis. Sci Transl Med. 2016 12 21; 8(370):370ec202.  View on PubMed
  17. Mallar Bhattacharya. Macrophages build a wall and the host pays for it. Science Translational Medicine. 2016 Nov 9; 8(364).  View on PubMed
  18. Mallar Bhattacharya. Stiff discipline for cells in pulmonary hypertension. Science Translational Medicine. 2016 Sep 28; 8(358):358ec154-358ec154.  View on PubMed
  19. Mallar Bhattacharya. Airway architect Adam33 in asthma. Science Translational Medicine. 2016 Aug 17; 8(352):352ec130-352ec130.  View on PubMed
  20. Mallar Bhattacharya. The gut takes a “Toll” on the lung. Science Translational Medicine. 2016 Jul 6; 8(346):346ec106-346ec106.  View on PubMed

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