Research Summary

Dr. Bhattacharya attends at Moffitt Hospital ICU and directs a research laboratory at the Mission Bay Campus focused on the functions of lung macrophages. Ongoing studies are exploring the role of macrophage interactions with other cell types in lung disease models, including lung fibrosis and asthma.

Research Funding

  • May 1, 2016 - April 30, 2021 - The Regulation of RhoA Activation in Airway Smooth Muscle, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL131560
  • September 1, 2012 - June 30, 2017 - IQGAP1 In Vascular Barrier Regulation During Acute Lung Injury, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: K08HL114641
  • January 1, 2011 - December 31, 2011 - Regulation of Endothelial Permeability by Integrin alpha-v beta-3, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: F32HL099026
  • May 1, 2016 - April 30, 2021 - The Regulation of RhoA Activation in Airway Smooth Muscle, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL131560

Education

Harvard University, Cambridge, MA, A.B., 06/1998, Biology and Psychology
Oxford University, Oxford, United Kingdom, M.Sc., 10/1999, Neuroscience
Harvard University, Boston, MA, M.D., 06/2004, Medicine
Johns Hopkins Hospital, Baltimore, MD, Residency, 06/2007, Internal Medicine
University of California, San Francisco, CA, Fellowship, 06/2010, Pulmonary and Critical Care

Honors & Awards

  • 2008-2009
    Will Rogers Institute Fellowship
  • 2000
    American Neurological Association Summer Fellowship
  • 2000
    Pasteur Summer Research Fellowship for Medical Students
  • 1997
    Member, Phi Beta Kappa Society, Harvard College Chapter
  • 1994-1998
    New York State Robert C. Byrd Honors Scholarship
  • 1994-1998
    Dean's List, Harvard College
  • 1995, 97, 98
    John Harvard Scholarship
  • 1996
    Harvard College Scholarship

Selected Publications

  1. Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.  View on PubMed
  2. Looney AP, Bhattacharya M Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts.  View on PubMed
  3. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage.  View on PubMed
  4. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.  View on PubMed
  5. Bhattacharya M Could a coffee a day keep the inflammasome away?  View on PubMed
  6. Bhattacharya M Mesenchymal metamorphosis.  View on PubMed
  7. Mallar Bhattacharya Stiff discipline for cells in pulmonary hypertension.  View on PubMed
  8. Mallar Bhattacharya Airway architect Adam33 in asthma.  View on PubMed
  9. Mallar Bhattacharya The gut takes a “Toll” on the lung.  View on PubMed
  10. Mallar Bhattacharya Unwanted guests: Bacterial microbiome in COPD.  View on PubMed
  11. Mallar Bhattacharya H5N1 stems the alveolar tide: MSCs to the rescue!.  View on PubMed
  12. Bhattacharya M, Kallet RH, Ware LB, Matthay MA Negative-Pressure Pulmonary Edema.  View on PubMed
  13. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.  View on PubMed
  14. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5.  View on PubMed
  15. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.  View on PubMed
  16. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.  View on PubMed
  17. Mallar Bhattacharya, Michael A. Matthay, Hamid Rabb CHAPTER 188 Acute Respiratory Distress Syndrome and the Kidney: Lung and Kidney Crosstalk.  View on PubMed
  18. Mallar Bhattacharya, Benjamin M. Yeh, Aliya Qayyum, Fergus V. Coakley Case 81.  View on PubMed
  19. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.  View on PubMed

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