Research Funding

  • January 1, 2018 - December 31, 2021 - Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function , Principal Investigator . Sponsor: NIH, Sponsor Award ID: I01BX003814
  • April 1, 2008 - January 31, 2021 - Role of IGF-I/integrin signaling in the periosteal response to load , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR055924
  • July 1, 2003 - May 31, 2016 - Vitamin D Receptor Coactivators in Keratinocytes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR050023
  • February 15, 2001 - August 31, 2015 - IGF-1 Mediates the Anabolic Effects of PTH on Bone , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK054793

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Bikle DD. Vitamin D Regulation of Immune Function. Curr Osteoporos Rep. 2022 May 04.  View on PubMed
  2. Bikle DD. Vitamin D regulation of immune function during covid-19. Rev Endocr Metab Disord. 2022 04; 23(2):279-285.  View on PubMed
  3. Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 03; 37(4):853-861.  View on PubMed
  4. Bikle DD. Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers. JBMR Plus. 2021 Dec; 5(12):e10578.  View on PubMed
  5. Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE. Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D. Osteoporos Int. 2021 Dec; 32(12):2587-2592.  View on PubMed
  6. Bikle DD. Vitamin D regulation of and by long non coding RNAs. Mol Cell Endocrinol. 2021 07 15; 532:111317.  View on PubMed
  7. Celli A, Tu CL, Lee E, Bikle DD, Mauro TM. Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin. J Invest Dermatol. 2021 11; 141(11):2577-2586.  View on PubMed
  8. Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J. Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman. JBMR Plus. 2021 Jan; 5(1):e10445.  View on PubMed
  9. Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD. Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair. Endocrinology. 2020 12 01; 161(12).  View on PubMed
  10. Yoshizaki K, Fukumoto S, Bikle DD, Oda Y. Transcriptional Regulation of Dental Epithelial Cell Fate. Int J Mol Sci. 2020 Nov 25; 21(23).  View on PubMed
  11. Bikle DD. The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status. JBMR Plus. 2021 Jan; 5(1):e10418.  View on PubMed
  12. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19. Eur J Endocrinol. 2020 Nov; 183(5):R133-R147.  View on PubMed
  13. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration. PLoS One. 2020; 15(8):e0238076.  View on PubMed
  14. Oda Y, Bikle DD. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World J Stem Cells. 2020 Jul 26; 12(7):604-611.  View on PubMed
  15. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-γ1 signaling. J Cell Physiol. 2020 12; 235(12):9399-9413.  View on PubMed
  16. Xie Z, Wang X, Bikle DD. Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2020; 11:40.  View on PubMed
  17. Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020 04; 16(4):234-252.  View on PubMed
  18. Bikle DD. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J Endocr Soc. 2020 Feb 01; 4(2):bvz038.  View on PubMed
  19. Bikle DD. The Vitamin D Receptor as Tumor Suppressor in Skin. Adv Exp Med Biol. 2020; 1268:285-306.  View on PubMed
  20. Bouillon R, Bikle D. Vitamin D Metabolism Revised: Fall of Dogmas. J Bone Miner Res. 2019 11; 34(11):1985-1992.  View on PubMed

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