Research Summary

I am Professor of Medicine and Dermatology emeritus on call back at UCSF and staff Endocrinologist at SFVAMC. I continue both my clinical activities and direct a well funded laboratory investigating hormonal regulation of fracture healing and vitamin D and calcium regulation of both skin cancer and wound response.

Research Funding

  • October 1, 2022 - September 30, 2026 - BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to bone (FRACTURECURB): Role of abaloparatide for fracture healing , PI . Sponsor: VA, Sponsor Award ID: 1I01 BX005854
  • July 15, 2021 - June 3, 2026 - Maladaptive Plasticity in Spinal Cord Injury: Cellular Mechanisms , PI of subcontract . Sponsor: NIH, Sponsor Award ID: R01NS122888
  • June 1, 2022 - May 31, 2026 - Biomechanical computed tomography facilitates the diagnosis of osteoporosis and fracture prediction in patients with high risk prostate cancer , PI . Sponsor: DOD, Sponsor Award ID: PC210172
  • January 1, 2018 - December 31, 2021 - Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function , Principal Investigator . Sponsor: NIH, Sponsor Award ID: I01BX003814

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y. Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics. Commun Biol. 2023 Jul 21; 6(1):766.  View on PubMed
  2. Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate. J Steroid Biochem Mol Biol. 2023 Jun 16; 232:106352.  View on PubMed
  3. Bikle DD. Vitamin D and Long Covid: Is there a role in prevention or treatment? J Clin Endocrinol Metab. 2023 Jun 06.  View on PubMed
  4. Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP. Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship? Rev Endocr Metab Disord. 2023 04; 24(2):121-138.  View on PubMed
  5. Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, Cantorna MT. Highlights from the 24th workshop on vitamin D in Austin, September 2022. J Steroid Biochem Mol Biol. 2023 04; 228:106247.  View on PubMed
  6. Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D. Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporos Int. 2023 Mar; 34(3):551-561.  View on PubMed
  7. Mauro T, Bikle D. Skin and bone crosstalk during aging. Nat Aging. 2022 10; 2(10):874-875.  View on PubMed
  8. Bikle DD. Role of vitamin D and calcium signaling in epidermal wound healing. J Endocrinol Invest. 2022 Aug 13.  View on PubMed
  9. Seal KH, Bertenthal D, Bikle DD. Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 10; 37(13):3494.  View on PubMed
  10. Bikle DD. Vitamin D Regulation of Immune Function. Curr Osteoporos Rep. 2022 06; 20(3):186-193.  View on PubMed
  11. Bikle DD. Vitamin D regulation of immune function during covid-19. Rev Endocr Metab Disord. 2022 04; 23(2):279-285.  View on PubMed
  12. Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 03; 37(4):853-861.  View on PubMed
  13. Bikle DD. Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers. JBMR Plus. 2021 Dec; 5(12):e10578.  View on PubMed
  14. Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE. Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D. Osteoporos Int. 2021 Dec; 32(12):2587-2592.  View on PubMed
  15. Bikle DD. Vitamin D regulation of and by long non coding RNAs. Mol Cell Endocrinol. 2021 07 15; 532:111317.  View on PubMed
  16. Celli A, Tu CL, Lee E, Bikle DD, Mauro TM. Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin. J Invest Dermatol. 2021 11; 141(11):2577-2586.  View on PubMed
  17. Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J. Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman. JBMR Plus. 2021 Jan; 5(1):e10445.  View on PubMed
  18. Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD. Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair. Endocrinology. 2020 12 01; 161(12).  View on PubMed
  19. Yoshizaki K, Fukumoto S, Bikle DD, Oda Y. Transcriptional Regulation of Dental Epithelial Cell Fate. Int J Mol Sci. 2020 Nov 25; 21(23).  View on PubMed
  20. Bikle DD. The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status. JBMR Plus. 2021 Jan; 5(1):e10418.  View on PubMed

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