Research Funding

  • January 1, 2018 - December 31, 2021 - Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function, Principal Investigator. Sponsor: VA, Sponsor Award ID: I01BX003814
  • April 1, 2008 - January 31, 2020 - Role of IGF-I/integrin signaling in the periosteal response to load, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: R01AR055924
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource, Co-Investigator. Sponsor: NIH, Sponsor Award ID: P41RR001614
  • July 1, 2003 - September 27, 2010 - Vitamin D Receptor Coactivators in Keratinocytes, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: R01AR050023

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair.  View on PubMed
  2. Yoshizaki K, Fukumoto S, Bikle DD, Oda Y Transcriptional Regulation of Dental Epithelial Cell Fate.  View on PubMed
  3. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.  View on PubMed
  4. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration.  View on PubMed
  5. Oda Y, Bikle DD Vitamin D and calcium signaling in epidermal stem cells and their regeneration.  View on PubMed
  6. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling.  View on PubMed
  7. Xie Z, Wang X, Bikle DD Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.  View on PubMed
  8. Bikle D, Christakos S New aspects of vitamin D metabolism and action - addressing the skin as source and target.  View on PubMed
  9. Bikle DD Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level.  View on PubMed
  10. Bikle DD The Vitamin D Receptor as Tumor Suppressor in Skin.  View on PubMed
  11. Bouillon R, Bikle D Vitamin D Metabolism Revised: Fall of Dogmas.  View on PubMed
  12. Munson S, Wang Y, Chang W, Bikle DD Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.  View on PubMed
  13. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.  View on PubMed
  14. Bikle DD Do sunscreens block vitamin D production? A critical review by an international panel of experts.  View on PubMed
  15. Christakos S, Li S, De La Cruz J, Bikle DD New developments in our understanding of vitamin metabolism, action and treatment.  View on PubMed
  16. Bikle DD, Schwartz J Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.  View on PubMed
  17. Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner.  View on PubMed
  18. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome.  View on PubMed
  19. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.  View on PubMed
  20. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.  View on PubMed

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