Trever G. Bivona, MD, PhD
Professor of Medicine (joint with Cellular and Molecular Pharmacology), UCSF; Senior Investigator, Chan-Zuckerberg Biohub
I am a cell and molecular biologist and a board-certified medical oncologist. I lead a basic and translational research program focused on signal transduction and cancer genetics and the molecular basis of tumor initiation and progression. My discoveries have provided insight into the function and regulation of critical cancer-driving proteins including oncogenic receptor tyrosine kinases and RAS pathway genes. Of note, recent work that forms the basis of this proposal uncovered a distinct mode of kinase-mediated RAS signaling in cancer via membraneless cytoplasmic protein granules. My work also uncovered drug resistance programs mediated by NF-kappaB and Hippo-YAP pathway signaling and lineage plasticity switches in lung cancer and cancer dormancy. The overall goal of my research program is to understand the regulatory principles underlying cell signaling pathways, cancer growth, and metastasis through hypothesis-driven investigations in order to improve cancer therapy and patient survival. I direct the NCI-funded U54 Bay Area Drug Resistance and Sensitivity Center within the Cancer Moonshot program. I have successfully mentored over 20 individuals into independent academic and industry positions over the last 10 years and serve as co-PI on the UCSF NCI-funded K12 translational oncology training program. I am a Chan-Zuckerberg Biohub Senior Investigator and an elected member of the ASCI.
Vanderbilt University, B.S., 1998, Molecular Biology
New York University, School of Medicine, Ph.D., 2004, Cell and Mol. Biology
New York University, School of Medicine, M.D., 2005, Medicine
Brigham and Women’s Hospital/Harvard, 2005-2007, Internal Medicine
Memorial Sloan-Kettering Cancer Center, 2007-2011, Medical Oncology