Research Summary

In April 2015, I became the inaugural Director of the Bakar Computational Health Sciences Institute at the University of California, San Francisco, with the role of recruiting new computational-related faculty to UCSF.

My prior decade was spent at Stanford University, where I advanced from Assistant to Full Professor and Division Chief by developing and using bioinformatics methods to integrate, leverage, and reason over genomic and other molecular and clinical data sets to yield tools for physicians and patients. Example of this method includes work on cancer drug discovery (PNAS, 2000), type 2 diabetes (PNAS, 2003, 2012), fat cell formation (Nature Cell Biology, 2005), obesity (Bioinformatics, 2007), and transplantation (PNAS, 2009). To facilitate this, we developed tools to index public genomic data sets (Nature Biotechnology, 2006), reuse gene expression data (Nature Methods, 2007, 2010; Nature Communications 2015), and for cloud-computing (Nature Biotechnology, 2010). With these methods, we explore human physiology using electronic health record data (Science, 2008; Science Translational Medicine, 2014), estimate medical risk with whole genomes (Lancet, 2010), computationally reposition drugs (Science Translational Medicine, 2011). In newer work, we are studying entire medical systems through real-world clinical data (Journal of Clinical Investigation, 2020).

My research lab currently has 3 graduate students, 7 post-doctoral research fellows, and 3 staff members. I have successfully administered multiple research projects, including the NIAID ImmPort data archival repository, collaborated with many other researchers around the world, and continue to produce many peer-reviewed publications from each project. I have been heavily invested in teaching and mentoring. I am currently training or have trained 30 post-doctoral scholars in my research lab, with many obtaining prestigious research positions after departing. Twelve graduate students are completing, or have completed their PhD work in the lab, including two members of underrepresented minorities.

Research Funding

  • April 1, 2020 - March 31, 2025 - Computational models of naturally acquired immunity to falciparum malaria, Co-Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: U01AI150741
  • September 26, 2016 - April 30, 2021 - Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for Disease Stratification of Endometriosis, Co-Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: R01HD089511
  • September 1, 2015 - August 31, 2020 - Stanford and Northrop Grumman proposal for the Oncology Models Forum, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U24CA195858
  • April 15, 2014 - March 31, 2019 - Biorepository of Human iPSCs for Studying Dilated and Hypertrophic Cardiomyopathy, Co-Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R24HL117756

Education

Brown University, Providence, RI, A.B./Honors, 1987–1991, Computer Science
Brown University Medical School, RI, M.D., 1991–1995, Medicine
Children’s Hospital and Harvard, Boston, MA, Residency, 1995–1998, Pediatrics
Children’s Hospital and Harvard, Boston, MA, Fellowship, 1998–2001, Pediatric Endocrinology,
Massachusetts Institute of Technology, MA Sc.M. 1998–2002 Medical Informatics
Harvard Medical School and MIT, MA Ph.D. 2002–2004 Health Sci Technology

Honors & Awards

  • 2002, 2003
    Outstanding Speaker, American Association for Clinical Chemistry (awarded twice)
  • 2006
    PhRMA Foundation Informatics Research Starter Grant
  • 2006
    Howard Hughes Medical Institute Physician-Scientist Early Career Award
  • 2007
    Genome Technology magazine “Tomorrow’s Principal Investigator” award
  • 2008
    American Medical Informatics Association New Investigator Award
  • 2009
    Elected into the American College of Medical Informatics
  • 2010
    Young Investigator Award, Society for Pediatric Research
  • 2011
    National Human Genome Research Institute (NHGRI) Genomic Advance of the Month
  • 2012
    Recognized for Outstanding Scientific Accomplishment and Lectureship by the NIH Director (Wednesday Afternoon Lecture Series, WALS)
  • 2013
    Elected into the American Society of Clinical Investigation (ASCI)
  • 2013
    Awarded White House Champion of Change in Open Science
  • 2014
    Kavli Frontiers of Science Invited Fellow for the Indonesian-American Symposium, National Academy of Science
  • 2014
    E. Mead Johnson Award, Society for Pediatrics Research
  • 2015
    Elected to the National Academy of Medicine (NAS)

Selected Publications

  1. Peterson TA, Fontil V, Koliwad SK, Patel A, Butte AJ Quantifying Variation in Treatment Utilization for Type 2 Diabetes Across Five Major University of California Health Systems.  View on PubMed
  2. Nelson CA, Acuna AU, Paul AM, Scott RT, Butte AJ, Cekanaviciute E, Baranzini SE, Costes SV Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases.  View on PubMed
  3. Butte AJ Trials and Tribulations-11 Reasons Why We Need to Promote Clinical Trials Data Sharing.  View on PubMed
  4. Patel NA, Butte AJ Characteristics and challenges of the clinical pipeline of digital therapeutics.  View on PubMed
  5. Reznikov LR, Norris MH, Vashisht R, Bluhm AP, Li D, Liao YJ, Brown A, Butte AJ, Ostrov DA Identification of antiviral antihistamines for COVID-19 repurposing.  View on PubMed
  6. Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.  View on PubMed
  7. Arneson D, Elliott M, Mosenia A, Oskotsky B, Solodar S, Vashisht R, Zack T, Bleicher P, Butte AJ, Rudrapatna VA CovidCounties is an interactive real time tracker of the COVID19 pandemic at the level of US counties.  View on PubMed
  8. Madhavan S, Bastarache L, Brown JS, Butte AJ, Dorr DA, Embi PJ, Friedman CP, Johnson KB, Moore JH, Kohane IS, Payne PRO, Tenenbaum JD, Weiner MG, Wilcox AB, Ohno-Machado L Use of electronic health records to support a public health response to the COVID-19 pandemic in the United States: a perspective from 15 academic medical centers.  View on PubMed
  9. Eaneff S, Obermeyer Z, Butte AJ The Case for Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies.  View on PubMed
  10. Norgeot B, Quer G, Beaulieu-Jones BK, Torkamani A, Dias R, Gianfrancesco M, Arnaout R, Kohane IS, Saria S, Topol E, Obermeyer Z, Yu B, Butte AJ Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist.  View on PubMed
  11. Hu Z, Tang A, Singh J, Bhattacharya S, Butte AJ A robust and interpretable end-to-end deep learning model for cytometry data.  View on PubMed
  12. Arneson D, Elliott M, Mosenia A, Oskotsky B, Vashisht R, Zack T, Bleicher P, Butte AJ, Rudrapatna VA CovidCounties - an interactive, real-time tracker of the COVID-19 pandemic at the level of US counties.  View on PubMed
  13. Norgeot B, Muenzen K, Peterson TA, Fan X, Glicksberg BS, Schenk G, Rutenberg E, Oskotsky B, Sirota M, Yazdany J, Schmajuk G, Ludwig D, Goldstein T, Butte AJ Protected Health Information filter (Philter): accurately and securely de-identifying free-text clinical notes.  View on PubMed
  14. Rough K, Dai AM, Zhang K, Xue Y, Vardoulakis LM, Cui C, Butte AJ, Howell MD, Rajkomar A Predicting Inpatient Medication Orders From Electronic Health Record Data.  View on PubMed
  15. Kosti I, Lyalina S, Pollard KS, Butte AJ, Sirota M Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth.  View on PubMed
  16. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R Time for NIH to lead on data sharing.  View on PubMed
  17. Rudrapatna VA, Glicksberg BS, Avila P, Harding-Theobald E, Wang C, Butte AJ Accuracy of medical billing data against the electronic health record in the measurement of colorectal cancer screening rates.  View on PubMed
  18. Kurnat-Thoma E, Baranova A, Baird P, Brodsky E, Butte AJ, Cheema AK, Cheng F, Dutta S, Grant C, Giordano J, Maitland-van der Zee AH, Fridsma DB, Jarrin R, Kann MG, Keeney J, Loscalzo J, Madhavan G, Maron BA, McBride DK, McKean M, Mun SK, Palmer JC, Patel B, Parakh K, Pariser AR, Pristipino C, Radstake TRDJ, Rajasimha HK, Rouse WB, Rozman D, Saleh A, Schmidt HHHW, Schultz N, Sethi T, Silverman EK, Skopac J, Svab I, Trujillo S, Valentine JE, Verma D, West BJ, Vasudevan S Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine.  View on PubMed
  19. Nam SM, Peterson TA, Butte AJ, Seo KY, Han HW Explanatory Model of Dry Eye Disease Using Health and Nutrition Examinations: Machine Learning and Network-Based Factor Analysis From a National Survey.  View on PubMed
  20. Rudrapatna VA, Butte AJ Opportunities and challenges in using real-world data for health care.  View on PubMed

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