Research Summary

Dr. Jason Chan is a radiation oncologist who specializes in the treatment of head and neck, skull base, cutaneous, and thoracic malignancies. Dr. Chan received his undergraduate and medical degrees from Brown University. He completed his Internal Medicine internship at Kaiser Permanente San Francisco and his residency in Radiation Oncology at UCSF. He is an investigator in a number of translational studies and clinical trials in head and neck and lung cancers. His research interests include HPV-associated oropharyngeal cancer, nasopharyngeal cancer, lung, thyroid, and cutaneous malignancies. His clinical practice offers a wide range of treatment options for first time and repeat radiotherapy including Cyberknife radiosurgery and high-dose-rate brachytherapy.

Education

MD, - , Brown University
Residency, - , University of California, San Francisco

Selected Publications

  1. Bhethanabotla RM, Gulati A, Khalsa IK, Evans C, Perrin CE, Lappin JJ, Kidane J, Crosby TW, Chan JW, Yom SS, Young VN, Rosen CA, Schneider SL, Ha PK, Boscardin WJ, Laus J, Ryan WR, Ma Y. Swallowing Function Outcomes in Head and Neck Cancer Survivors Followed by a Long-Term Dysphagia Surveillance Protocol. Head Neck. 2025 May 05.  View on PubMed
  2. Phuong C, Ni L, Sharma M, Cunha JAM, Yom SS, Hsu IC, Chan JW. Outcomes and dosimetric analysis of reirradiation of oral cavity and oropharyngeal cancers with high-dose-rate brachytherapy. Brachytherapy. 2025 May-Jun; 24(3):413-419.  View on PubMed
  3. Machtay M, Torres-Saavedra PA, Thorstad W, Nguyen-Tân PF, Siu LL, Holsinger FC, El-Naggar A, Chung C, Cmelak A, Burtness B, Bednarz G, Quon H, Breen SL, Gwede CK, Dicker AP, Yao M, Jordan RC, Dorth J, Lee N, Chan JW, Dunlap N, Bar-Ad V, Stokes WA, Chakravarti A, Sher D, Rao S, Harris J, Yom SS, Le QT, NRG Oncology RTOG 0920 Collaborating Team, TransSCOT Consortium. Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer. J Clin Oncol. 2025 Apr 20; 43(12):1474-1487.  View on PubMed
  4. Vasudevan HN, Lazar AA, Reyes K, Rong DA, Arevalo S, Federman S, Chan JW, Chiu CY, Miller S, Yom SS. Comparison of Plasma Metagenomic Next-generation Sequencing and PCR Methods for Epstein-Barr Virus Viral Load Monitoring in Nasopharyngeal Carcinoma. Anticancer Res. 2024 Dec; 44(12):5445-5453.  View on PubMed
  5. Malik NH, Montero M, Chen JJ, Sinha S, Yom SS, Chan JW. Higher area deprivation index is associated with poorer local control and overall survival in non-metastatic nasopharyngeal carcinoma. Head Neck. 2024 06; 46(6):1468-1474.  View on PubMed
  6. Singhrao K, Dugan CL, Calvin C, Pelayo L, Yom SS, Chan JW, Scholey JE, Singer L. Evaluating the Hounsfield unit assignment and dose differences between CT-based standard and deep learning-based synthetic CT images for MRI-only radiation therapy of the head and neck. J Appl Clin Med Phys. 2024 Jan; 25(1):e14239.  View on PubMed
  7. Massachi J, Singer L, Glastonbury C, Scholey J, Singhrao K, Calvin C, Yom SS, Chan JW. Incidental findings and safety events from magnetic resonance imaging simulation for head and neck radiation treatment planning: A single institution experience. Tech Innov Patient Support Radiat Oncol. 2024 Mar; 29:100228.  View on PubMed
  8. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Lam TC, Pu JK, Li LF, Leung GK, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Patel AJ, Sahm F, Magill ST, Raleigh DR. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 Dec; 29(12):3067-3076.  View on PubMed
  9. Plonowska-Hirschfeld KA, Gulati A, Stephens EM, Ochoa E, Xu MJ, Ha PK, Heaton CM, Yom SS, Chan JW, Algazi A, Kang H, Ryan WR. Treatment Modality Impact on Patient-Reported Quality of Life in Human Papilloma Virus-Associated Oropharyngeal Carcinoma. Laryngoscope. 2024 04; 134(4):1687-1695.  View on PubMed
  10. Gulati A, Plonowska-Hirschfeld K, Stephens EM, Kansara S, Zebolsky AL, Ochoa E, Xu MJ, Ha PK, Heaton CM, Yom SS, Chan JW, Algazi AP, Kang H, Ryan WR. A prospective evaluation of neck and shoulder function following treatments of early-stage human papillomavirus-associated oropharynx cancer. Clin Otolaryngol. 2023 Sep; 48(5):756-765.  View on PubMed
  11. Ching JCF, Lam S, Lam CCH, Lui AOY, Kwong JCK, Lo AYH, Chan JWH, Cai J, Leung WS, Lee SWY. Integrating CT-based radiomic model with clinical features improves long-term prognostication in high-risk prostate cancer. Front Oncol. 2023; 13:1060687.  View on PubMed
  12. Oliver DE, Laborde JM, Singh DP, Milano MT, Videtic GM, Williams GR, LaRiviere MJ, Chan JW, Peters GW, Decker RH, Samson P, Robinson CG, Breen WG, Owen D, Tian S, Higgins KA, Almeldin D, Jabbour SK, Wang F, Grass GD, Perez BA, Dilling TJ, Strosberg J, Rosenberg SA. Early-Stage Primary Lung Neuroendocrine Tumors Treated With Stereotactic Body Radiation Therapy: A Multi-Institution Experience. Int J Radiat Oncol Biol Phys. 2023 Jul 15; 116(4):849-857.  View on PubMed
  13. Lee RH, Wai KC, Chan JW, Ha PK, Kang H. Approaches to the Management of Metastatic Adenoid Cystic Carcinoma. Cancers (Basel). 2022 Nov 20; 14(22).  View on PubMed
  14. Sinha S, Chan JW. Just Because You Could, Does Not Mean You Should. Int J Radiat Oncol Biol Phys. 2022 Nov 01; 114(3):384.  View on PubMed
  15. Benjamin DJ, Chen S, Eldredge JB, Schokrpur S, Li D, Quan Z, Chan JW, Cummings AL, Daly ME, Goldman JW, Gubens MA, Harris JP, Onaitis MW, Zhu VW, Patel SP, Kelly K. The Role of Chemotherapy Plus Immune Checkpoint Inhibitors in Oncogenic-Driven NSCLC: A University of California Lung Cancer Consortium Retrospective Study. JTO Clin Res Rep. 2022 Dec; 3(12):100427.  View on PubMed
  16. Subramaniam RM, DeMora L, Yao M, Yom SS, Gillison M, Caudell JJ, Waldron J, Xia P, Chung CH, Truong MT, Echevarria M, Chan JW, Geiger JL, Mell L, Seaward S, Thorstad WL, Beitler JJ, Sultanem K, Blakaj D, Le QT. 18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus-Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002. J Nucl Med. 2023 03; 64(3):362-367.  View on PubMed
  17. Kidane J, Laus J, Gulati A, Gochman GE, Schneider SL, Chan JW, Yom SS, Ha P, Boscardin WJ, Ryan WR, Ma Y. Longitudinal Analysis of Swallowing Displacement Kinematics After Oropharyngeal Cancer Treatment. Laryngoscope. 2023 06; 133(6):1339-1348.  View on PubMed
  18. Cheung CK, Chew J, Wai K, Calkins SM, Ha PK, Ryan WR, Cunha A, Yom SS, Hsu IC, Chan JW. Feasibility of accelerated image-guided high-dose-rate interstitial brachytherapy with inverse planning simulated annealing (IPSA-HDRBT) for post-operative treatment of pathologically node-negative squamous cell carcinomas of the oral tongue. Brachytherapy. 2022 Sep-Oct; 21(5):686-691.  View on PubMed
  19. Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW. Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases. J Neurosurg. 2023 01 01; 138(1):104-112.  View on PubMed
  20. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659.  View on PubMed

Go to UCSF Profiles, powered by CTSI