Research Summary

Next-generation sequencing technologies developed in the last ten years have dramatically widened our view into the many kinds of events that are driving tumor biology. Gene fusions, copy number alterations, mutations, epigenetic changes, stromal microenvironment, immunogenicity and transcript level alterations can all be ascertained via the knife of DNA and RNA sequencing. Statistical methods, factor analysis, insights from evolutionary biology and immunology as well as an understanding of mutation processes at work in tumors can help us distill out the important driver events from the background of non-functional passenger mutations, and give us useful insights into the multiple systemic processes driving tumor progression.

I am specifically interested in using these integrated approaches to help understand and improve treatments for gynecologic cancers. However, the "organ of origin" approach has narrowed our view and exploring carcinogenesis pan-cancer will allow for novel insights into uncommon or difficult to treat gynecologic cancers. To this end, I collaborate with clinicians and scientists across oncology with a goal to further a model of cancer medicine in which genetic data is incorporated.

Education

Carnegie Mellon University, Pittsburgh, PA, B.F.A., 1996-1999, Classical piano
Columbia University, New York, NY, Post-bac, 2002-2003, Pre-medical sciences
Boston University School of Medicine, Boston, MA, M.D., 2004-2008, Medicine
University of California San Francisco, Resident, 2008-2012, Obstetrics, Gynecology & Reproductive Sciences
Stanford University and UCSF, Fellow, 2012-2015, Gynecologic Oncology

Honors & Awards

  • 2009
    Outstanding Resident Award in Medical Student Teaching
  • 2010
    Alpha Omega Alpha
  • 2011
    Resident Scholar - Association of Professors of Gynecology and Obstetrics
  • 2013 & 2014
    Outstanding Fellow Award in Medical Student Teaching
  • 2015
    Leo Lagasse Award for best fellow presentation on clinical research at the 2015 Western Association of Gynecologic Oncologists Annual Meeting

Selected Publications

  1. Peters PN, Pierson WE, Chen LM, Westphalen AC, Chapman JS, Hsu IC PET-detected asymptomatic recurrence is associated with improved survival in recurrent cervical cancer.  View on PubMed
  2. Pierson WE, Peters PN, Chang MT, Chen LM, Quigley DA, Ashworth A, Chapman JS An integrated molecular profile of endometrioid ovarian cancer.  View on PubMed
  3. Ahmad TR, Chen LM, Chapman JS, Chen LL Medicaid and Medicare payer status are associated with worse surgical outcomes in gynecologic oncology.  View on PubMed
  4. Ladwig NR, Schoolmeester JK, Weil L, Chapman JS, Zaloudek C, Umetsu SE Inflammatory Myofibroblastic Tumor Associated With the Placenta: Short Tandem Repeat Genotyping Confirms Uterine Site of Origin.  View on PubMed
  5. Manrriquez E, Chapman JS, Mak J, Blanco AM, Chen LM Disparities in genetics assessment for women with ovarian cancer: Can we do better?  View on PubMed
  6. Ohliger MA, Hope TA, Chapman JS, Chen LM, Behr SC, Poder L PET/MR Imaging in Gynecologic Oncology.  View on PubMed
  7. Chen LM, Chen LL, Chapman JS In Reply.  View on PubMed
  8. Chapman JS, Roddy E, Ueda S, Brooks R, Chen LL, Chen LM Enhanced Recovery Pathways for Improving Outcomes After Minimally Invasive Gynecologic Oncology Surgery.  View on PubMed
  9. Klauschen F, Bläker H, Stenzinger A, Chapman JS, Collisson EA, Taylor BS Re: "Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course".  View on PubMed
  10. Chapman JS, Collisson EA, Taylor BS The Authors Respond.  View on PubMed
  11. Chang MT, Asthana S, Gao SP, Lee BH, Chapman JS, Kandoth C, Gao J, Socci ND, Solit DB, Olshen AB, Schultz N, Taylor BS Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.  View on PubMed
  12. Chapman JS, Asthana S, Cade L, Chang MT, Wang Z, Zaloudek CJ, Ueda S, Collisson EA, Taylor BS Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course.  View on PubMed
  13. Chapman JS, Roddy E, Westhoff G, Simons E, Brooks R, Ueda S, Chen L Post-operative enteral immunonutrition for gynecologic oncology patients undergoing laparotomy decreases wound complications.  View on PubMed
  14. Chapman JS, Jacoby V, Chen LM Managing symptoms and maximizing quality of life after preventive interventions for cancer risk reduction.  View on PubMed
  15. Chapman JS, Powell CB, McLennan J, Crawford B, Mak J, Stewart N, Chen LM Surveillance of survivors: follow-up after risk-reducing salpingo-oophorectomy in BRCA 1/2 mutation carriers.  View on PubMed
  16. Saleeby E, Chapman J, Morse J, Bryant A H1N1 influenza in pregnancy: cause for concern.  View on PubMed
  17. Friedman S, Chen C, Chapman JS, Jeruss S, Terrin N, Tighiouart H, Parsons SK, Wilson JM Neurodevelopmental outcomes of congenital diaphragmatic hernia survivors followed in a multidisciplinary clinic at ages 1 and 3.  View on PubMed
  18. Chen C, Jeruss S, Chapman JS, Terrin N, Tighiouart H, Glassman E, Wilson JM, Parsons SK Long-term functional impact of congenital diaphragmatic hernia repair on children.  View on PubMed

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