Research Summary

Next-generation sequencing technologies developed in the last ten years have dramatically widened our view into the many kinds of events that are driving tumor biology. Gene fusions, copy number alterations, mutations, epigenetic changes, stromal microenvironment, immunogenicity and transcript level alterations can all be ascertained via the knife of DNA and RNA sequencing. Statistical methods, factor analysis, insights from evolutionary biology and immunology as well as an understanding of mutation processes at work in tumors can help us distill out the important driver events from the background of non-functional passenger mutations, and give us useful insights into the multiple systemic processes driving tumor progression.

I am specifically interested in using these integrated approaches to help understand and improve treatments for gynecologic cancers. However, the "organ of origin" approach has narrowed our view and exploring carcinogenesis pan-cancer will allow for novel insights into uncommon or difficult to treat gynecologic cancers. To this end, I collaborate with clinicians and scientists across oncology with a goal to further a model of cancer medicine in which genetic data is incorporated.

Education

Carnegie Mellon University, Pittsburgh, PA, B.F.A., 1996-1999, Classical piano
Columbia University, New York, NY, Post-bac, 2002-2003, Pre-medical sciences
Boston University School of Medicine, Boston, MA, M.D., 2004-2008, Medicine
University of California San Francisco, Resident, 2008-2012, Obstetrics, Gynecology & Reproductive Sciences
Stanford University and UCSF, Fellow, 2012-2015, Gynecologic Oncology

Honors & Awards

  • 2009
    Outstanding Resident Award in Medical Student Teaching
  • 2010
    Alpha Omega Alpha
  • 2011
    Resident Scholar - Association of Professors of Gynecology and Obstetrics
  • 2013 & 2014
    Outstanding Fellow Award in Medical Student Teaching
  • 2015
    Leo Lagasse Award for best fellow presentation on clinical research at the 2015 Western Association of Gynecologic Oncologists Annual Meeting

Selected Publications

  1. Roddy E, Chapman J. Genomic insights in gynecologic cancer. Curr Probl Cancer. 2017 Jan - Feb; 41(1):8-36.  View on PubMed
  2. Chapman JS, Roddy E, Westhoff G, Simons E, Brooks R, Ueda S, Chen L. Post-operative enteral immunonutrition for gynecologic oncology patients undergoing laparotomy decreases wound complications. Gynecol Oncol. 2015 Jun; 137(3):523-8.  View on PubMed
  3. Henderson JT, Harper CC, Gutin S, Saraiya M, Chapman J, Sawaya GF. Routine bimanual pelvic examinations: practices and beliefs of US obstetrician-gynecologists. Am J Obstet Gynecol. 2013 Feb; 208(2):109.e1-7.  View on PubMed
  4. Saleeby E, Chapman J, Morse J, Bryant A. H1N1 influenza in pregnancy: cause for concern. Obstet Gynecol. 2009 Oct; 114(4):885-891.  View on PubMed
  5. Friedman S, Chen C, Chapman JS, Jeruss S, Terrin N, Tighiouart H, Parsons SK, Wilson JM. Neurodevelopmental outcomes of congenital diaphragmatic hernia survivors followed in a multidisciplinary clinic at ages 1 and 3. J Pediatr Surg. 2008 Jun; 43(6):1035-43.  View on PubMed
  6. Chen C, Jeruss S, Chapman JS, Terrin N, Tighiouart H, Glassman E, Wilson JM, Parsons SK. Long-term functional impact of congenital diaphragmatic hernia repair on children. J Pediatr Surg. 2007 Apr; 42(4):657-65.  View on PubMed

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