Jason G. Cyster, PhD
Professor, Department of Microbiology and Immunology, UCSF
We study the intercellular communications and cell migration dynamics underlying anti-pathogen and anti-tumor immune responses. We are recognized for defining how lymphoid microenvironments are organized to support adaptive immunity. We played a key role in the discovery of lymphoid tissue chemokines and established the concept that chemokines continuously guide cells to supportive niches. Our group led the way in defining how cells exit from lymphoid organs, a process essential for immune function. We showed the egress-promoting role of sphingosine-1-phosphate and identified the mechanism of action of key egress regulators, including the immunosuppressive molecule FTY720 (Fingolimod). We use immunological, genetic, cell biological, biochemical, and intravital imaging techniques to study these processes. As well as performing mechanistic studies in mouse models, we have translated key findings to humans, such as our identification of a gene pathway that is disrupted in germinal center B cell-type diffuse large B cell lymphoma.
University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology