Research Summary

I have 20 years experience managing an NIH- and HHMI-funded immunology research laboratory. My research has involved defining the intercellular communications acting between immune cells to support adaptive immune responses. My group uses immunological, genetic, cell biological, and advanced imaging techniques to study these processes. Although many of our studies are performed using the mouse as a model, in several cases we have translated their work to humans, such as our recent identification of a novel gene pathway that is disrupted in germinal center B cell-type diffuse large B cell lymphoma (GCB-DLBCL).

I have been a research mentor for a large number graduate students, postdoctoral fellows, and clinical fellows. Many of my early trainees, including three past graduate students and fourteen postdoctoral fellows, are now Assistant or Associate Professors, and a number of both types of trainees hold scientist positions in the biotech sector. I have had a long-standing commitment to education with my involvement in teaching in immunology and cell biology courses in the graduate and professional schools at UCSF, and I give several teaching lectures for other professional organizations each year. As Director of the BMS graduate program from 2005-2014, I have had a leadership role in promoting graduate education at UCSF and beyond.

Research Funding

  • April 1, 1997 - March 31, 2022 - B lymphocyte Migration and Homeostasis, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI040098
  • June 1, 2007 - May 31, 2017 - Cellular and Genetic Analysis of Lymphocyte Egress, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI074847
  • September 1, 1988 - May 31, 2014 - Molecular and Cellular Immunology, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: T32AI007334
  • April 1, 1999 - March 31, 2014 - Chemokines and Lymphoid Tissue Organization and Function, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI045073

Education

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology

Honors & Awards

  • 1984
    The Beazely Award for secondary education in Western Australia
  • 1988
    J.A. Wood Memorial prize from the University of Western Australia
  • 1989-1992
    Commonwealth Overseas Studentship
  • 1992-1995
    Cancer Research Institute Postdoctoral Fellowship
  • 1996-2000
    Pew Scholar in the Biomedical Sciences
  • 1997
    Cheryl Whitlock Memorial Prize for Postdoctoral Studies
  • 1998-2003
    David and Lucile Packard Foundation Fellowship
  • 2005
    AAI BD Biosciences Investigator Award
  • 2005
    External Speaker, Harvard Medical School Annual Immunology Retreat
  • 2009
    Alexandre Goidl Memorial Lectureship, University of Maryland Baltimore
  • 2009
    Keynote Speaker, Microanatomy of Immune Responses in Health and Disease, Birmingham, UK
  • 2010
    Organizing Committee Member, International Congress of Immunology, Kobe, Japan
  • 2010
    Keynote Presentation, Antibody Biology & Engineering Gordon Research Conference, Ventura, CA
  • 2010
    14th Köhler Lecture in Immunology, University of Freiburg, Germany
  • 2010
    CRI Fredrick W. Alt Award for New Discoveries in Immunology
  • 2011
    Distinguished Lecture, AAI Annual Meeting, San Francisco
  • 2011
    Elected as an AAAS Fellow
  • 2013
    Keynote Speaker, 14th International TNF conference
  • 2013
    Keynote Speaker, FASEB Meeting on Lysophospholipids
  • 2013
    Keynote Speaker, Gordon Conference on Follicular helper T cells.
  • 2018
    Elected, American Academy of Arts and Sciences

Selected Publications

  1. McMahon DE, Gallman AE, Hruza GJ, Rosenbach M, Lipoff JB, Desai SR, French LE, Lim H, Cyster JG, Fox LP, Fassett MS, Freeman EE Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.  View on PubMed
  2. Liu D, Wu J, An J, Cyster JG Requirements for cDC2 positioning in blood-exposed regions of the neonatal and adult spleen.  View on PubMed
  3. Laidlaw BJ, Cyster JG Transcriptional regulation of memory B cell differentiation.  View on PubMed
  4. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.  View on PubMed
  5. Laidlaw BJ, Duan L, Xu Y, Vazquez SE, Cyster JG The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.  View on PubMed
  6. Pamela L. Graney, Kristine Lai, Sarah Post, Ilana Brito, Jason Cyster, Ankur Singh Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells.  View on PubMed
  7. Pirgova G, Chauveau A, MacLean AJ, Cyster JG, Arnon TI Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.  View on PubMed
  8. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A Test performance evaluation of SARS-CoV-2 serological assays.  View on PubMed
  9. Mintz MA, Cyster JG T follicular helper cells in germinal center B cell selection and lymphomagenesis.  View on PubMed
  10. Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC, McAllister-Lucas LM GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.  View on PubMed
  11. Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenberg M, Dustin ML, Cyster JG The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.  View on PubMed
  12. Laidlaw BJ, Gray EE, Zhang Y, Ramírez-Valle F, Cyster JG Sphingosine-1-phosphate receptor 2 restrains egress of ?d T cells from the skin.  View on PubMed
  13. Lu E, Cyster JG G-protein coupled receptors and ligands that organize humoral immune responses.  View on PubMed
  14. Cyster JG, Allen CDC B Cell Responses: Cell Interaction Dynamics and Decisions.  View on PubMed
  15. Lu E, Wolfreys FD, Muppidi JR, Xu Y, Cyster JG S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.  View on PubMed
  16. Dang EV, Cyster JG Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why.  View on PubMed
  17. Wu J, Wu H, An J, Ballantyne CM, Cyster JG Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity.  View on PubMed
  18. Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.  View on PubMed
  19. Sumida H, Cyster JG G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.  View on PubMed
  20. Barnes MJ, Cyster JG Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gas proteins.  View on PubMed

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