I have performed clinical trials in hematologic malignancies and hematopoietic cell transplantation since 1988. My focus has been predominantly in the acute leukemias and lymphomas, with emphasis on novel chemotherapy drug schedules and dosing aimed at enhancing treatment efficacy and/or reducing treatment toxicity. I discovered the relationship of high-dose cytarabine neurotoxicity and renal insufficiency that led to a dose-modification scheme that reduced neurotoxicity risk (this has become the standard of care in physicians using high doses of cytarabine). I have explored methods of adding immunotherapy to autologous hematopoietic cell transplant, most notably the GVAX platform in AML in conjunction with the Johns Hopkins group. I was the national PI on CALGB protocol 59909 adding rituximab and autologous hematopoietic cell transplant to aggressive chemotherapy for mantle cell lymphoma. I am the UCSF sub-PI on the Ohio State University Blood and Marrow Transplant Research Consortium within the BMT CTN. I am the campus PI on the new University of California Hematologic Malignancies Research Consortium linking UCSF, UCSD, UCD, UCLA, UCSF Fresno and UCI to facilitate clinical and collaborative scientific research in blood cancers in California.
My research activities have been tempered by additional clinical and administrative responsibilities since achieving faculty status. Based on the waxing and waning of nonmalignant hematology faculty at UCSF, I have often had to shift my clinical work to nonmalignant activities (outpatient clinic and inpatient consults) multiple times over my career. At this time, my activities are half malignant and half non-malignant hematology. I served on the National Comprehensive Cancer Network guideline panels for adult acute myeloid leukemia, acute lymphoblastic leukemia, and non-Hodgkin lymphoma.
Olivet College, Olivet, Michigan, B.A., 1978, Chemistry/Biology
University of Michigan Medical School, Ann Arbor, M.D., 1982, Medicine
University of California San Francisco, Residency, 1985, Internal Medicine
University of California San Francisco, Fellowship, 1988, Hematology/Oncology