Research Summary

My primary interests are in the application of statistical methods to medical and social-science research. I have a long history of research in psychiatry and psychology with an emphasis on studies of addiction. My work in modeling latent variables has also lead to a productive collaboration which has uncovered sub-phenotypes among patients with acute respiratory distress syndrome. As other colleagues do, I also consult with scientists across a wide range of research areas.

Research Funding

  • September 30, 1991 - June 30, 2024 - Substance Use Disorders Treatment/Services Research Training Program , Co-Investigator . Sponsor: NIH, Sponsor Award ID: T32DA007250
  • September 29, 1994 - May 31, 2016 - Treatment for Complex Patients: Continuing and Extended Care , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50DA009253
  • August 1, 1994 - December 31, 2011 - Impact of Services on Problem Drinking Trajectories , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AA009750

Education

University of San Francisco, BA, 1976, Psychology
University of California, Berkeley, MA, 1979, Quantitative Methods
University of California, Berkeley, PhD, 1986, Quantitative Methods

Honors & Awards

  • 2003-2009
    Faculty, American Psychiatric Association Research Colloq for Jr Investigators
  • 2004-present
    Member, Special Emphasis Panels, NIH
  • 2007-present
    Chartered Member, CSR Study Section: Relapse, Prevention, and Intervention in Addictions

Selected Publications

  1. Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS. Agreement between Sepsis-2 and Sepsis-3 Definitions among Patients Admitted to the Intensive Care Unit. Ann Am Thorac Soc. 2025 Mar; 22(3):460-462.  View on PubMed
  2. Rezoagli E, Xin Y, Signori D, Sun W, Gerard S, Delucchi KL, Magliocca A, Vitale G, Giacomini M, Mussoni L, Montomoli J, Subert M, Ponti A, Spadaro S, Poli G, Casola F, Herrmann J, Foti G, Calfee CS, Laffey J, Bellani G, Cereda M, CT-COVID19 Multicenter Study Group. Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan. Crit Care. 2024 08 05; 28(1):263.  View on PubMed
  3. Nelson JC, Delucchi KL. Commentary on Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment. Am J Geriatr Psychiatry. 2024 Nov; 32(11):1337-1339.  View on PubMed
  4. Vijayaraghavan M, Elser H, Delucchi K, Tsoh JY, Lynch K, Weiser SD, Riley ED. Distinct patterns of cigarette smoking intensity and other substance use among women who experience housing instability. Addict Behav. 2024 09; 156:108066.  View on PubMed
  5. Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS. Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Crit Care. 2024 05 14; 28(1):164.  View on PubMed
  6. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS. Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Crit Care. 2024 04 22; 28(1):132.  View on PubMed
  7. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS. Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Am J Respir Crit Care Med. 2024 04 01; 209(7):805-815.  View on PubMed
  8. Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS. Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time. Am J Respir Crit Care Med. 2024 04 01; 209(7):816-828.  View on PubMed
  9. DeMerle KM, Kennedy JN, Chang CH, Delucchi K, Huang DT, Kravitz MS, Shapiro NI, Yealy DM, Angus DC, Calfee CS, Seymour CW. Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial. Sci Rep. 2024 03 14; 14(1):6234.  View on PubMed
  10. Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial. Crit Care. 2024 02 21; 28(1):56.  View on PubMed
  11. Campbell BK, Le T, McCuistian C, Bonniot C, Delucchi K, Guydish J. Policy and Practice Changes Associated with a Tobacco-Free Initiative in Residential Substance Use Disorder Treatment. J Psychoactive Drugs. 2024 Feb 16; 1-10.  View on PubMed
  12. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Lancet Respir Med. 2023 11; 11(11):965-974.  View on PubMed
  13. Pagano A, Le T, Fong T, Reid R, Delucchi K, Guydish J. Gambling, tobacco use, and health among individuals in substance use disorder treatment. Am J Addict. 2023 11; 32(6):563-573.  View on PubMed
  14. Flori HR, Zhang M, Xie J, Yang G, Sapru A, Calfee CS, Delucchi KL, Sinha P, Curley MAQ, Dahmer MK. Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes. Am J Respir Crit Care Med. 2023 08 01; 208(3):331-333.  View on PubMed
  15. Guydish J, McCuistian C, Hosakote S, Le T, Masson CL, Campbell BK, Delucchi K. A cluster-randomized trial of a brief multi-component intervention to improve tobacco outcomes in substance use treatment. Subst Abuse Treat Prev Policy. 2023 06 16; 18(1):34.  View on PubMed
  16. Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM. Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Crit Care. 2023 06 13; 27(1):234.  View on PubMed
  17. Martínez C, Lisha N, McCuistian C, Straus E, Delucchi K, Guydish J. Corrigendum: Comparing client and staff reports on tobacco-related knowledge, attitudes, beliefs and services provided in substance use treatment. Tob Induc Dis. 2023; 21:59.  View on PubMed
  18. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. Subphenotypes of frailty in lung transplant candidates. Am J Transplant. 2023 04; 23(4):531-539.  View on PubMed
  19. Niendam TA, Loewy R, Savill M, Delucchi KL, Lesh TA, Ragland JD, Bolden K, Skymba HV, Gobrial S, Meyer MS, Pierce KM, Rosenthal A, Fedechko TL, Tully LM, Tryon VL, Goldman H, Cress RD, Kravitz RL, Carter CS. Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated Psychosis: A Cluster Randomized Clinical Trial. JAMA Psychiatry. 2023 02 01; 80(2):119-126.  View on PubMed
  20. Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network. The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Crit Care. 2022 09 29; 26(1):297.  View on PubMed

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