Research Summary

My primary interests are in the application of statistical methods to medical and social-science research. I have a long history of research in psychiatry and psychology with an emphasis on studies of addiction. My work in modeling latent variables has also lead to a productive collaboration which has uncovered sub-phenotypes among patients with acute respiratory distress syndrome. As other colleagues do, I also consult with scientists across a wide range of research areas.

Research Funding

  • September 30, 1991 - June 30, 2024 - Substance Use Disorders Treatment/Services Research Training Program , Co-Investigator . Sponsor: NIH, Sponsor Award ID: T32DA007250
  • September 29, 1994 - May 31, 2016 - Treatment for Complex Patients: Continuing and Extended Care , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50DA009253
  • August 1, 1994 - December 31, 2011 - Impact of Services on Problem Drinking Trajectories , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AA009750

Education

University of San Francisco, BA, 1976, Psychology
University of California, Berkeley, MA, 1979, Quantitative Methods
University of California, Berkeley, PhD, 1986, Quantitative Methods

Honors & Awards

  • 2003-2009
    Faculty, American Psychiatric Association Research Colloq for Jr Investigators
  • 2004-present
    Member, Special Emphasis Panels, NIH
  • 2007-present
    Chartered Member, CSR Study Section: Relapse, Prevention, and Intervention in Addictions

Selected Publications

  1. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Lancet Respir Med. 2023 Aug 23.  View on PubMed
  2. Pagano A, Le T, Fong T, Reid R, Delucchi K, Guydish J. Gambling, tobacco use, and health among individuals in substance use disorder treatment. Am J Addict. 2023 Aug 06.  View on PubMed
  3. Flori HR, Zhang M, Xie J, Yang G, Sapru A, Calfee CS, Delucchi KL, Sinha P, Curley MAQ, Dahmer MK. Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes. Am J Respir Crit Care Med. 2023 08 01; 208(3):331-333.  View on PubMed
  4. Guydish J, McCuistian C, Hosakote S, Le T, Masson CL, Campbell BK, Delucchi K. A cluster-randomized trial of a brief multi-component intervention to improve tobacco outcomes in substance use treatment. Subst Abuse Treat Prev Policy. 2023 Jun 16; 18(1):34.  View on PubMed
  5. Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM. Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Crit Care. 2023 06 13; 27(1):234.  View on PubMed
  6. Martínez C, Lisha N, McCuistian C, Straus E, Delucchi K, Guydish J. Corrigendum: Comparing client and staff reports on tobacco-related knowledge, attitudes, beliefs and services provided in substance use treatment. Tob Induc Dis. 2023; 21:59.  View on PubMed
  7. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. Subphenotypes of frailty in lung transplant candidates. Am J Transplant. 2023 04; 23(4):531-539.  View on PubMed
  8. Niendam TA, Loewy R, Savill M, Delucchi KL, Lesh TA, Ragland JD, Bolden K, Skymba HV, Gobrial S, Meyer MS, Pierce KM, Rosenthal A, Fedechko TL, Tully LM, Tryon VL, Goldman H, Cress RD, Kravitz RL, Carter CS. Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated Psychosis: A Cluster Randomized Clinical Trial. JAMA Psychiatry. 2023 02 01; 80(2):119-126.  View on PubMed
  9. Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network. The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Crit Care. 2022 09 29; 26(1):297.  View on PubMed
  10. Pagano A, McCuistian C, Le T, Campbell BK, Delucchi K, Woodward-Lopez G, Guydish J. Smoking Behavior and Wellness among Individuals in Substance Use Disorder Treatment. J Psychoactive Drugs. 2023 Jul-Aug; 55(3):330-341.  View on PubMed
  11. Jiang Y, Delucchi K, Kaiser N, Hinshaw SP, McBurnett K, Pfiffner LJ. The Two-Factor Structure of the Parent Cognitive Error Questionnaire: A Measure of Parental Cognitive Errors in Relation to Child Problems. Res Child Adolesc Psychopathol. 2022 Oct; 50(10):1249-1260.  View on PubMed
  12. Anderson ACT, Richards A, Delucchi K, Khalili M. Coverage, inequity and predictors of hepatitis B birth vaccination in Myanmar from 2011-2016: results from a national survey. BMC Health Serv Res. 2022 Apr 19; 22(1):516.  View on PubMed
  13. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Am J Respir Crit Care Med. 2022 04 15; 205(8):927-935.  View on PubMed
  14. Nguyen N, Wong M, Delucchi K, Halpern-Felsher B. Adolescents' and young adults' perceptions of risks and benefits differ by type of cannabis products. Addict Behav. 2022 08; 131:107336.  View on PubMed
  15. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022 04; 10(4):367-377.  View on PubMed
  16. Dahmer MK, Yang G, Zhang M, Quasney MW, Sapru A, Weeks HM, Sinha P, Curley MAQ, Delucchi KL, Calfee CS, Flori H, RESTORE and BALI study investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis. Lancet Respir Med. 2022 03; 10(3):289-297.  View on PubMed
  17. Sinha P, Spicer A, Delucchi KL, McAuley DF, Calfee CS, Churpek MM. Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials. EBioMedicine. 2021 Dec; 74:103697.  View on PubMed
  18. Sinha P, Furfaro D, Cummings MJ, Abrams D, Delucchi K, Maddali MV, He J, Thompson A, Murn M, Fountain J, Rosen A, Robbins-Juarez SY, Adan MA, Satish T, Madhavan M, Gupta A, Lyashchenko AK, Agerstrand C, Yip NH, Burkart KM, Beitler JR, Baldwin MR, Calfee CS, Brodie D, O'Donnell MR. Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids. Am J Respir Crit Care Med. 2021 12 01; 204(11):1274-1285.  View on PubMed
  19. McCuistian C, Kapiteni K, Le T, Safier J, Delucchi K, Guydish J. Reducing tobacco use in substance use treatment: An intervention to promote tobacco-free grounds. J Subst Abuse Treat. 2022 04; 135:108640.  View on PubMed
  20. McCuistian C, Le T, Delucchi K, Pagano A, Hosakote S, Guydish J. Racial/Ethnic Differences in Tobacco Use and Cessation Services among Individuals in Substance Use Treatment. J Psychoactive Drugs. 2021 Nov-Dec; 53(5):483-490.  View on PubMed

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