Research Summary

My primary interests are in the application of statistical methods to medical and social-science research. I have a long history of research in psychiatry and psychology with an emphasis on studies of addiction. My work in modeling latent variables has also lead to a productive collaboration which has uncovered sub-phenotypes among patients with acute respiratory distress syndrome. As other colleagues do, I also consult with scientists across a wide range of research areas.

Research Funding

  • September 30, 1991 - June 30, 2024 - Substance Use Disorders Treatment/Services Research Training Program, Co-Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: T32DA007250
  • September 1, 1997 - May 31, 2015 - Treatment for Complex Patients: Continuing and Extended Care, Co-Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: P50DA009253
  • August 1, 1994 - November 30, 1997 - Impact of Services on Problem Drinking Trajectories, Principal Investigator. Sponsor: NIH/NIAAA, Sponsor Award ID: R01AA009750
  • September 30, 1991 - June 30, 2024 - Substance Use Disorders Treatment/Services Research Training Program, Co-Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: T32DA007250

Education

University of San Francisco, BA, 1976, Psychology
University of California, Berkeley, MA, 1979, Quantitative Methods
University of California, Berkeley, PhD, 1986, Quantitative Methods

Honors & Awards

  • 2003-2009
    Faculty, American Psychiatric Association Research Colloq for Jr Investigators
  • 2004-present
    Member, Special Emphasis Panels, NIH
  • 2007-present
    Chartered Member, CSR Study Section: Relapse, Prevention, and Intervention in Addictions

Selected Publications

  1. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022 Jan 10.  View on PubMed
  2. Dahmer MK, Yang G, Zhang M, Quasney MW, Sapru A, Weeks HM, Sinha P, Curley MAQ, Delucchi KL, Calfee CS, Flori H, RESTORE and BALI study investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis. Lancet Respir Med. 2021 Dec 06.  View on PubMed
  3. Sinha P, Spicer A, Delucchi KL, McAuley DF, Calfee CS, Churpek MM. Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials. EBioMedicine. 2021 Nov 30; 74:103697.  View on PubMed
  4. McCuistian C, Kapiteni K, Le T, Safier J, Delucchi K, Guydish J. Reducing tobacco use in substance use treatment: An intervention to promote tobacco-free grounds. J Subst Abuse Treat. 2021 Oct 23; 108640.  View on PubMed
  5. McCuistian C, Le T, Delucchi K, Pagano A, Hosakote S, Guydish J. Racial/Ethnic Differences in Tobacco Use and Cessation Services among Individuals in Substance Use Treatment. J Psychoactive Drugs. 2021 Oct 21; 1-8.  View on PubMed
  6. Riley ED, Delucchi K, Rubin S, Weiser SD, Vijayaraghavan M, Lynch K, Tsoh JY. Ongoing tobacco use in women who experience homelessness and unstable housing: A prospective study to inform tobacco cessation interventions and policies. Addict Behav. 2021 Sep 25; 125:107125.  View on PubMed
  7. Sinha P, Furfaro D, Cummings MJ, Abrams D, Delucchi K, Maddali MV, He J, Thompson A, Murn M, Fountain J, Rosen A, Robbins-Juarez SY, Adan MA, Satish T, Madhavan M, Gupta A, Lyashchenko AK, Agerstrand C, Yip NH, Burkart KM, Beitler JR, Baldwin MR, Calfee CS, Brodie D, O'Donnell MR. Latent Class Analysis Reveals COVID-19-related ARDS Subgroups with Differential Responses to Corticosteroids. Am J Respir Crit Care Med. 2021 Sep 20.  View on PubMed
  8. Rubin SB, Vijayaraghavan M, Weiser SD, Tsoh JY, Cohee A, Delucchi K, Riley ED. Homeless women's perspectives on smoking and smoking cessation programs: A qualitative study. Int J Drug Policy. 2021 Sep 01; 98:103377.  View on PubMed
  9. Yonek JC, Meacham MC, Ramo D, Delucchi K, Tolou-Shams M, Satre DD. The Relationship of E-Cigarette Use to Tobacco Use Outcomes Among Young Adults Who Smoke and Use Alcohol. J Addict Med. 2021 Sep-Oct 01; 15(5):421-424.  View on PubMed
  10. Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS. Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Thorax. 2021 Jul 12.  View on PubMed
  11. Dutra Silva J, Su Y, Calfee CS, Delucchi KL, Weiss D, McAuley DF, O'Kane C, Krasnodembskaya AD. Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS. Eur Respir J. 2021 07; 58(1).  View on PubMed
  12. Guydish J, Le T, Hosakote S, Straus E, Wong J, Martínez C, Delucchi K. Tobacco use among substance use disorder (SUD) treatment staff is associated with tobacco-related services received by clients. J Subst Abuse Treat. 2021 Jun 01; 132:108496.  View on PubMed
  13. McKelvey K, Gaiha SM, Delucchi KL, Halpern-Felsher B. Measures of both perceived general and specific risks and benefits differentially predict adolescent and young adult tobacco and marijuana use: findings from a Prospective Cohort Study. Humanit Soc Sci Commun. 2021; 8(1).  View on PubMed
  14. Mayer SE, Surachman A, Prather AA, Puterman E, Delucchi KL, Irwin MR, Danese A, Almeida DM, Epel ES. The long shadow of childhood trauma for depression in midlife: examining daily psychological stress processes as a persistent risk pathway. Psychol Med. 2021 Mar 26; 1-10.  View on PubMed
  15. Vogel EA, Ramo DE, Rubinstein ML, Delucchi KL, Darrow SM, Costello C, Prochaska JJ. Effects of Social Media on Adolescents' Willingness and Intention to Use E-Cigarettes: An Experimental Investigation. Nicotine Tob Res. 2021 03 19; 23(4):694-701.  View on PubMed
  16. Lebares CC, Coaston TN, Delucchi KL, Guvva EV, Shen WT, Staffaroni AM, Kramer JH, Epel ES, Hecht FM, Ascher NL, Harris HW, Cole SW. Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials. Ann Surg. 2021 03 01; 273(3):424-432.  View on PubMed
  17. Borsari B, Li Y, Tighe J, Manuel JK, Gökbayrak NS, Delucchi K, Morasco BJ, Abadjian L, Cohen BE, Baxley C, Seal KH. A pilot trial of collaborative care with motivational interviewing to reduce opioid risk and improve chronic pain management. Addiction. 2021 09; 116(9):2387-2397.  View on PubMed
  18. Lebares CC, Greenberg AL, Ascher NL, Delucchi KL, Reilly LM, van der Schaaf M, Baathe F, O'Sullivan P, Isaksson Rø K. Exploration of Individual and System-Level Well-being Initiatives at an Academic Surgical Residency Program: A Mixed-Methods Study. JAMA Netw Open. 2021 01 04; 4(1):e2032676.  View on PubMed
  19. Sinha P, Calfee CS, Delucchi KL. Practitioner's Guide to Latent Class Analysis: Methodological Considerations and Common Pitfalls. Crit Care Med. 2021 01 01; 49(1):e63-e79.  View on PubMed
  20. Nutley SK, Camacho MR, Eichenbaum J, Nosheny RL, Weiner M, Delucchi KL, Mackin RS, Mathews CA. Hoarding disorder is associated with self-reported cardiovascular / metabolic dysfunction, chronic pain, and sleep apnea. J Psychiatr Res. 2021 02; 134:15-21.  View on PubMed

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