Research Funding

  • August 1, 1996 - June 30, 2023 - Oral and Craniofacial Sciences Health Research Training, Principal Investigator. Sponsor: NIH, Sponsor Award ID: T32DE007306
  • March 7, 2019 - February 28, 2023 - Enamel biomineralization; the role of pH cycling, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01DE027971
  • March 1, 2014 - February 28, 2017 - WDR72 in Tooth Enamel Formation, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21DE023411
  • December 1, 1999 - August 31, 2015 - Enamel Fluorosis: Mechanisms of Action, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01DE013508
  • February 1, 2010 - January 31, 2013 - Effects of Fluoride on Behavior in Genetically Diverse Mouse Models, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21ES017813
  • December 1, 1999 - August 31, 2011 - Enamel Fluorosis: Mechanisms of Action, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R56DE013508
  • February 19, 2008 - January 31, 2011 - Genetic Variations Related to Fluorosis Susceptibility, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21DE018633
  • August 2, 2007 - July 31, 2009 - Ameloblast Differentiation In Vitro: A Step Closer to Enamel Engineering, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R21DE017910
  • August 1, 1991 - June 30, 2008 - Characterization and Modification of Dental Hard Tissues , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01DE009859
  • August 1, 1999 - July 31, 2006 - NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P60DE013058
  • April 1, 1996 - March 31, 1999 - FLUORIDE EFFECTS ON AMELOBLAST LIKE CELLS IN CULTURE , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE011733
  • February 1, 1994 - January 31, 1999 - AMELOGENIN PROCESSING BY SERINE PROTEINASE(S) IN ENAMEL , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE010614
  • September 30, 1992 - September 29, 1995 - EXPRESSION OF AMELOGENIN IN RNA DURING ENAMEL FORMATION , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE010546
  • September 1, 1990 - August 31, 1994 - ALTERATIONS IN AMELOBLAST FUNCTION IN ENAMEL FLUOROSIS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE009389
  • December 1, 1988 - November 30, 1991 - PROTEINASES IN DEVELOPING ENAMEL MATRIX , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE008706
  • July 1, 1990 - June 30, 1991 - EFFECTS OF PRENATAL FLUORIDE EXPOSURE ON FETAL RAT BONE , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE009642
  • September 1, 1985 - August 31, 1990 - EFFECTS OF CHRONIC HIGH FLUORIDE ON ENAMEL DEVELOPMENT , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R29DE007384
  • September 1, 1985 - August 31, 1988 - EFFECTS OF CHRONIC HIGH FLUORIDE ON ENAMEL DEVELOPMENT , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R23DE007384

Education

  • St. Olaf College, Minnesota, B.S., 1976, Chemistry
  • University of Iowa, D.D.S., 1980, Dentistry
  • University of North Carolina, M.S., 1983, Pediatric Dentistry
  • University of North Carolina, Postdoc, 1985, Mineralized Tissue

Honors & Awards

  • 2021
    Fellow, American Assocation for Dental Research
  • 2013
    Fellow, American Association for the Advancement of Science
  • 2011
    UCSF School of Dentistry Faculty Research Award
  • 2009
    IADR Distinguished Scientist Award

Selected Publications

  1. Den Besten P, Wells CR, Abduweli Uyghurturk D. Fluoride exposure and blood cell markers of inflammation in children and adolescents in the United States: NHANES, 2013-2016. Environ Health. 2022 Oct 27; 21(1):102.  View on PubMed
  2. Földes A, Reider H, Varga A, Nagy KS, Perczel-Kovach K, Kis-Petik K, DenBesten P, Ballagi A, Varga G. Culturing and Scaling up Stem Cells of Dental Pulp Origin Using Microcarriers. Polymers (Basel). 2021 Nov 15; 13(22).  View on PubMed
  3. Földes A, Sang-Ngoen T, Kádár K, Rácz R, Zsembery Á, DenBesten P, Steward MC, Varga G. Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel Formation. Front Pharmacol. 2021; 12:682654.  View on PubMed
  4. Kádár K, Juhász V, Földes A, Rácz R, Zhang Y, Löchli H, Kató E, Köles L, Steward MC, DenBesten P, Varga G, Zsembery Á. TRPM7-Mediated Calcium Transport in HAT-7 Ameloblasts. Int J Mol Sci. 2021 Apr 13; 22(8).  View on PubMed
  5. Abduweli Uyghurturk D, Goin DE, Martinez-Mier EA, Woodruff TJ, DenBesten PK. Maternal and fetal exposures to fluoride during mid-gestation among pregnant women in northern California. Environ Health. 2020 04 06; 19(1):38.  View on PubMed
  6. Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Abduweli Uyghurturk D, Jalai R, Onur SG, Mentes A, DenBesten PK. Fluoride related changes in behavioral outcomes may relate to increased serotonin. Physiol Behav. 2019 07 01; 206:76-83.  View on PubMed
  7. Al-Ansari S, Jalali R, Plotkin LI, Bronckers ALJJ, DenBesten P, Zhang Y, Raber-Durlacher JE, de Lange J, Rozema FR. The Importance of Connexin 43 in Enamel Development and Mineralization. Front Physiol. 2018; 9:750.  View on PubMed
  8. Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC. Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 05; 97(5):483-491.  View on PubMed
  9. Rácz R, Földes A, Bori E, Zsembery Á, Harada H, Steward MC, DenBesten P, Bronckers ALJJ, Gerber G, Varga G. No Change in Bicarbonate Transport but Tight-Junction Formation Is Delayed by Fluoride in a Novel Ameloblast Model. Front Physiol. 2017; 8:940.  View on PubMed
  10. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 11 22; 9(11):e3.  View on PubMed
  11. Jalali R, Lodder JC, Zandieh-Doulabi B, Micha D, Melvin JE, Catalan MA, Mansvelder HD, DenBesten P, Bronckers A. The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice. Front Physiol. 2017; 8:924.  View on PubMed
  12. Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers A. Corrigendum to " Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors" [Archives of Oral Biology 29 (July (83)) (2017) 214-221]. Arch Oral Biol. 2017 12; 84:177.  View on PubMed
  13. Varga G, DenBesten P, Rácz R, Zsembery Á. Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies. Oral Dis. 2018 Sep; 24(6):879-890.  View on PubMed
  14. Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers ALJJ. Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors. Arch Oral Biol. 2017 Nov; 83:214-221.  View on PubMed
  15. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 08 18; 292(33):13531-13540.  View on PubMed
  16. Bronckers AL, Lyaruu DM, Jalali R, DenBesten PK. Buffering of protons released by mineral formation during amelogenesis in mice. Eur J Oral Sci. 2016 10; 124(5):415-425.  View on PubMed
  17. Kunimatsu R, Yoshimi Y, Hirose N, Awada T, Miyauchi M, Takata T, Li W, Zhu L, Denbesten PK, Tanimoto K. The C-terminus of amelogenin enhances osteogenic differentiation of human cementoblast lineage cells. J Periodontal Res. 2017 Apr; 52(2):218-224.  View on PubMed
  18. Yoshimi Y, Kunimatsu R, Hirose N, Awada T, Miyauchi M, Takata T, Li W, Zhu L, Denbesten P, Tanne K, Tanimoto K. Effects of C-Terminal Amelogenin Peptide on Proliferation of Human Cementoblast Lineage Cells. J Periodontol. 2016 Jul; 87(7):820-7.  View on PubMed
  19. Bronckers AL, Lyaruu D, Jalali R, Medina JF, Zandieh-Doulabi B, DenBesten PK. Ameloblast Modulation and Transport of Cl⁻, Na⁺, and K⁺ during Amelogenesis. J Dent Res. 2015 Dec; 94(12):1740-7.  View on PubMed
  20. Jalali R, Zandieh-Doulabi B, DenBesten PK, Seidler U, Riederer B, Wedenoja S, Micha D, Bronckers AL. Slc26a3/Dra and Slc26a6 in Murine Ameloblasts. J Dent Res. 2015 Dec; 94(12):1732-9.  View on PubMed

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