Research Summary

My primary research focus is the supportive care aspects of pediatric hematopoietic cell transplantation (HCT), with a goal of decreasing treatment-related morbidity and mortality, especially infections, through clinical trials. I am the past-Chair of the international Pediatric Blood and Marrow Transplant Consortium’s (PBMTC) Supportive Care Strategy Group, where I led individuals in the design of pilot multi-center trials in this field. These trials serve as the basis for the design of larger phase III trials in the Children’s Oncology Group (COG). In the COG, I am the Chair of the Cancer Control & Supportive Care Committee, and serve on the Cellular Therapy Committee, overseeing the design of trials in this field.

I was the national principal investigator on the COG protocol ACCL1131: An Open-Label Phase III Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections Undergoing Allogeneic HCT. I was the national vice-chair for COG ACCL1034: Impact of Cleaning with Chlorhexidine Gluconate on Reducing Central Line Associate Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms. I am the national vice-chair of PBMTC SUP1601: Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection.

Other areas of interest include the optimization of conditioning regimens for young patients undergoing HCT. I was the national principal investigator on another COG trial, ASCT1221: A Randomized Phase II Study Comparing Two Different Conditioning Regimens Prior to Allogeneic Hematopoietic Cell Transplantation for Children with JMML.

Research Funding

  • September 3, 2024 - August 31, 2029 - Primary Immune Deficiency Treatment Consortium (PIDTC): A resource to drive scientific and clinical advances related to the treatment of inborn errors of immunity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R24AI184316
  • September 12, 2009 - August 31, 2024 - Primary Immune Deficiency Treatment Consortium , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54AI082973

Education

University of California at San Diego, BS, 1994, Molecular Biology
Vanderbilt University School of Medicine, MD, 1998, Medicine
Stanford University School of Medicine, Intern, 1999, Pediatrics
Stanford University School of Medicine, Resident, 2001, Pediatrics
Stanford University School of Medicine, Fellow, 2005, Hematology/Oncology

Honors & Awards

  • 1990-1994
    Regents Scholar, University of California at San Diego
  • 2002-2005
    Arline & Pete Harman Pediatric Fellow, Lucile Packard Foundation for Children's Health
  • 2011
    Pediatric Faculty Leadership Award, UCSF Fellow's College

Selected Publications

  1. Collier WH, Zobeck M, Esbenshade AJ, Dvorak CC, Sung L, Freyer D, Alexander S, Orgel E, Ullrich NJ, Prudowsky Z, Fisher B, Elgarten CW. On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi-Center Phase-III Randomized Clinical Trials. Pediatr Blood Cancer. 2026 Jul 25; e70593. View on PubMed
  2. Winestone LE, Logan BR, Liu X, Williams O, Dunn EA, Thakar MS, Kidd SA, Mousallem T, Dorsey MJ, O'Reilly RJ, Kapoor N, Forbes Satter L, Kapadia M, Jyonouchi SC, Chandra S, Ebens CL, Chellapandian D, Chaudhury S, Chen K, Dávila Saldaña BJ, Rayes A, Quigg TC, Chandrakasan S, Bednarski JJ, DeSantes KB, Teira P, Gillio AP, Eissa H, Knutsen AP, Aquino VM, Shereck EB, Moore TB, Caywood EH, Vander Lugt MT, Rozmus J, Broglie L, Yu LC, Shah AJ, Joshi AY, Buckley RH, Dara J, Oved JH, Abdel Azim H, Martinez CA, Prockop S, Sullivan KE, Bleesing JJ, Keller MD, Madden LM, Parikh S, Shenoy S, Seroogy CM, Rubin T, Licata J, Andolina JR, Kohn DB, Burroughs L, Leiding JW, Marsh RA, Notarangelo LD, Pai SY, Torgerson TR, Pulsipher MA, Heimall J, Cuvelier GDE, Griffith LM, Puck JM, Dvorak CC, Cowan MJ, Haddad E. Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report. J Hum Immun. 2026 Sep 07; 2(5):e20250231. View on PubMed
  3. Arnold DE, Eissa H, Dunn E, Cuvelier GDE, Wright NAM, Marsh RA, Parikh S, Saldana BD, Vander Lugt MT, Bacchetta R, Satter LF, Chandrakasan S, Kellner E, Allenspach EJ, Schmitt EG, Logan B, Burroughs L, Cowan MJ, Griffith LM, Notarangelo L, Pai SY, Pulsipher MA, Dvorak CC, Haddad E, Puck JM, Torgerson TR, Leiding JW, Heimall J, Chan AY. IMPACT (Immune Monitoring and Phenotype Assessment of Clinical Trajectory) for Patients With Inborn Errors of Immunity From the Primary Immune Deficiency Treatment Consortium (PIDTC). J Allergy Clin Immunol Pract. 2026 Jun 03. View on PubMed
  4. Boelens JJ, Dvorak CC. Yes, we can omit TBI for ALL! Blood Adv. 2026 May 26; 10(10):3717-3718. View on PubMed
  5. Evans EM, Mayday MY, Pearce EM, Iwanaga K, Ly NP, Church GD, Reyes G, Simon MR, Blum J, Kim H, Mu J, Baez-Maidana J, Auletta JJ, Shaw PJ, Kreml EM, Martin PL, Duncan CN, Rowan CM, Godder K, Hurley C, Cuvelier GDE, Qayed M, Abdel-Azim H, Keating AK, Fitzgerald JC, Hanna R, Killinger JS, Hume JR, Quigg TC, Castillo P, Satwani P, Moore TB, Dvorak CC, Zinter MS, Pediatric Transplantation And Cell Therapy Consortium. Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation. Am J Respir Cell Mol Biol. 2026 May 19. View on PubMed
  6. Schoettler ML, Cheng G, Higham CS, Dvorak CC, Rush C, Rangarajan HG, Al-Nazer M, Polishchuk V, Chaudhury S, Lehmann L, Duncan C, Nishitani M, Manougian H, Rotz S, Ofori J, Frost E, Orbodo J, Spencer K, Kenney E, Chonat S, Chewning J, Moore C, Westbrook A, Williams KM. Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment. Transplant Cell Ther. 2026 Jul; 32(7):887.e1-887.e16. View on PubMed
  7. Switzer GE, Bruce JG, Shaw BE, Kuniyil V, Varni JW, Butler BJ, Erickson C, Mussetter A, Neutzling A, Abdel-Azim H, Aguayo-Hiraldo P, Anderson EJ, Aquino VM, Boone K, Boulad F, Chewning JH, Cooper J, Dahlberg A, Dvorak CC, Galvez-Silva J, Haight AE, Hoag JA, Hudspeth M, Jacobsohn D, Kasow KA, Kitko CL, Krishnamurti L, Madden L, Miller HK, Morales E, Olson TS, Pawlowska AB, Prasad VK, Quigg TC, Scaradavou A, Shah NC, Shenoy S, Terwilliger NB, Wiener L, Yanik GA, Yu LC, Pulsipher MA. Factors Associated With Pre-donation Health-related Quality-of-Life Among Pediatric Sibling Hematopoietic Cell Donors: A DonorKids QL Study. Transplant Cell Ther. 2026 Jul; 32(7):885.e1-885.e14. View on PubMed
  8. MacKenzie TC, Lianoglou BR, Gonzalez J, Dvorak CC, Kharbanda S, Herzeg A, Canepa E, Kreger EM, Frascoli M, Sper R, Gupta A, Leung J, Tang Q, Sinha R, Worthington AK, Gano D, Coco Bakkour S, Chafets D, Keller RL, Shimotake J, Lal A, Glenn OA, Moon-Grady A, Vichinsky EP. In Utero Hematopoietic Cell Transplantation in Fetuses with Alpha Thalassemia Major: A Phase 1 Clinical Trial. Blood Adv. 2026 Apr 15. View on PubMed
  9. Orange JS, Chinen J, Horner CC, Kobrynski LJ, Ballow M, Butte MJ, Chandrakasan S, Chinn IK, Satter LF, Freeman AF, Heimall JR, Knight V, Lawrence MG, Lehman HK, Maglione PJ, Perez EE, Risma KA, Walter JE, Abraham RS, Barmettler S, Broderick L, Chang CC, Chan AY, Chen K, Connelly J, Danziger-Isakov LA, De la Morena MT, DiGiacomo D, Dimitriades VR, Dorsey MJ, Dulek DE, Dutmer CM, Dvorak CC, Farmer JR, Frazer-Abel A, Joshi AY, Keller MD, Khan YW, Kitcharoensakkul M, Leiding JW, Myers KC, Nandakumar V, Platt CD, Pai SY, Patel NC, Pozos TC, Puck JM, Rider NL, Sacco KA, Williams KW, Lieberman JA, Rank MA, Shaker MS, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Ledford DK, Mosnaim G, Wang J. 2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS). Ann Allergy Asthma Immunol. 2026 Apr; 136(4):426-493.e1. View on PubMed
  10. Chan AY, Dvorak CC. TLR8 gain-of-function: on the highway to the danger zone. Blood Adv. 2026 Mar 24; 10(6):2047-2048. View on PubMed
  11. Alexander JL, Dávila Saldaña BJ, Brazauskas R, Dammalapati SG, Griffith LM, Shah AJ, Shimano KA, Ochs HD, Bleesing JJ, Ebens CL, Kapadia M, Bauchat A, Kapoor N, Oved JH, Eissa H, Lust H, Keller MD, Haines H, Chandrakasan S, Talano JA, Rayes A, Madden L, Shereck E, Miller HK, Satter LF, Martinez C, Rozmus J, Bednarski JJ, Yu LC, Chellapandian D, Aquino VM, Knutsen A, Chong H, Chopek A, Gillio AP, Joshi A, Rangarajan H, Moore TB, Andolina JR, DeSantes KB, Vander Lugt M, Prockop SE, Shyr DC, Sullivan KE, Parikh S, Weinacht KG, Torgerson TR, Marsh R, Dvorak CC, Chan AY, Haddad E, Heimall JR, Pulsipher MA, Leiding JW, Kohn DB, Puck JM, Notarangelo LD, Rawlings DJ, Cowan MJ, Petrovic A, Pai SY, Burroughs LM. Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood Adv. 2026 Mar 10; 10(5):1783-1798. View on PubMed
  12. Liberio N, Allbee-Johnson M, Ahn KW, Moskop A, Phelan R, Shaw BE, Page KM, Schultz KR, Phillips CL, Mehta PA, Qayed M, Sharma A, Lipsitt AE, Symons H, Bolaños-Meade J, Kharbanda S, Dvorak CC, Kapoor N, Doherty EE, Chavan RS, Broglie L. Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant. J Clin Oncol. 2026 Apr 10; 44(11):1003-1015. View on PubMed
  13. Rayes A, Logan BR, Liu X, Dara J, Buckley RH, Oved JH, Kapoor N, Kapadia M, Chandra S, Martinez CA, Bunin NJ, Chandrakasan S, Chen K, Bednarski JJ, Haines HL, Eissa H, Talano JM, Keller MD, Ebens CL, Chaudhury S, Shereck EB, Aquino VM, Knutsen AP, Alexander JL, Gillio AP, Chellapandian D, Shah AJ, Miller HK, Vander Lugt MT, Seroogy CM, Dorsey MJ, Mousallem T, Parrott RE, O'Reilly RJ, Aguayo-Hiraldo PI, Prockop SE, Dávila Saldaña BJ, Thakar MS, Burroughs LM, Torgerson TR, Leiding JW, Marsh RA, Griffith LM, Pulsipher MA, Kohn DB, Notarangelo L, Cowan MJ, Puck JM, Cuvelier GDE, Heimall J, Haddad E, Pai SY, Dvorak CC. Outcomes following matched sibling donor transplantation for severe combined immunodeficiency: a report from the PIDTC. Blood Adv. 2026 Feb 10; 10(3):887-900. View on PubMed
  14. Kharbanda S, Cho E, Chen J, Zhang M, Yalcin K, Yesilipek A, Yabe H, Lindemans C, van Hasselt P, Alghasi A, Fong N, Bhattacharya R, Sheikh I, Guilcher GMT, Grimard P, Tomatsu S, Dvorak CC. Allogeneic Hematopoietic Cell Transplantation for Morquio A Syndrome: An International Retrospective Study. Transplant Cell Ther. 2026 Jun; 32(6):703.e1-703.e11. View on PubMed
  15. Collier WH, Zobeck M, Esbenshade AJ, Dvorak CC, Sung L, Freyer D, Alexander S, Orgel E, Ullrich NJ, Prudowsky Z, Fisher B, Elgarten CW. Evaluating the use of hierarchical composite endpoints in pediatric cancer supportive care clinical trials: Illustrative examples from two multi-center phase-III randomized clinical trials. medRxiv. 2026 Jan 23. View on PubMed
  16. Chandrakasan S, Westbrook A, Griffith LM, Hagin D, Iyengar S, Mangurian C, Scalchunes C, Sullivan KE, Zablocki A, Bakshi N, Sinha C, Burroughs LM, Chan AY, Dvorak CC, Haddad E, Heimall J, Kohn DB, Leiding JW, Notarangelo LD, Pai SY, Puck JM, Pulsipher MA, Marsh RA, Torgerson T, Cowan MJ, Ochs HD, Parikh S. Clinical spectrum of Wiskott-Aldrich syndrome carriers: Self-reported survey of 193 carriers. Clin Immunol. 2026 Feb; 283:110658. View on PubMed
  17. Brumm VL, Kidd SA, Logan BR, Chunara F, Heimall J, Griffith LM, Kohn DB, Sanchez L, Bednarski JJ, Martinez C, Lugt MV, Kapoor N, Wright N, Spitzer B, Oved JH, Chandra S, Chellapandian D, Ebens CL, Petrovic A, Rayes A, Haines HL, Lust H, Schofield HT, Christopher L, Harris LL, Satter LF, Burroughs L, Dvorak CC, Haddad E, Leiding JW, Marsh RA, Notarangelo LD, Pai SY, Pulsipher MA, Puck JM, Cowan MJ, Shah AJ. Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency (SCID): A PIDTC study. J Hum Immun. 2026 Jan 05; 2(1):e20250163. View on PubMed
  18. Dvorak CC, Waters E, Temple WC, Salinas Cisneros G, Chu J, Winestone LE, Higham CS, Kharbanda S, Shimano KA, Avagyan S, Pauerstein P, Huang JN, Brooks JT, Long-Boyle JR. Fludarabine Pharmacokinetic Model-Based Dosing Minimizes the Risk of Graft Rejection in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther. 2026 Apr; 32(4):476.e1-476.e14. View on PubMed
  19. Hudda Z, Webster A, Anderson E, Badia P, Bagatell R, Bhar S, Bidgoli A, Boyd K, Chaudhury S, Cisneros GS, Craddock J, Davies SM, Desai AV, Drobatz L, Dvorak CC, Elkus H, Fabrizio VA, Foster JH, Fraint E, Freedman JL, Galvez J, Garcia M, Haight A, Higham C, Jodele S, Kamat A, Kaviany S, Lehmann L, Leung K, Lind KT, Llaurador G, Kapadia M, Khazal S, Massi K, Mormann M, Pater L, Rangarajan HG, Rotz S, Sabulski A, Sartain SE, Schoettler ML, Sokol E, Streby KA, Stein M, Verneris MR, Weiss BD, Yazdani S, Zheng D, Dandoy CE. Acute Toxicities and Early Outcomes of Tandem Autologous Stem Cell Transplantation in Pediatric High-Risk Neuroblastoma: A Multicenter Study. Transplant Cell Ther. 2026 Feb; 32(2):199.e1-199.e12. View on PubMed
  20. Smith MA, Hutchinson Z, Colglazier E, Parker C, Higham CS, Fineman JR, Zinter MS, Dvorak CC, Nawaytou HM. Early Echocardiographic and Serum Biomarkers Predict Thrombotic Microangiopathy, Endotheliopathy, and Survival After Pediatric Hematopoietic Stem Cell Transplant. Transplant Cell Ther. 2026 Mar; 32(3):306.e1-306.e13. View on PubMed

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