Research Summary

My primary research focus is the supportive care aspects of pediatric hematopoietic cell transplantation (HCT), with a goal of decreasing treatment-related morbidity and mortality, especially infections, through clinical trials. I am the past-Chair of the international Pediatric Blood and Marrow Transplant Consortium’s (PBMTC) Supportive Care Strategy Group, where I led individuals in the design of pilot multi-center trials in this field. These trials serve as the basis for the design of larger phase III trials in the Children’s Oncology Group (COG). In the COG, I am the Chair of the Cancer Control & Supportive Care Committee, and serve on the Cellular Therapy Committee, overseeing the design of trials in this field.

I was the national principal investigator on the COG protocol ACCL1131: An Open-Label Phase III Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections Undergoing Allogeneic HCT. I was the national vice-chair for COG ACCL1034: Impact of Cleaning with Chlorhexidine Gluconate on Reducing Central Line Associate Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms. I am the national vice-chair of PBMTC SUP1601: Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection.

Other areas of interest include the optimization of conditioning regimens for young patients undergoing HCT. I was the national principal investigator on another COG trial, ASCT1221: A Randomized Phase II Study Comparing Two Different Conditioning Regimens Prior to Allogeneic Hematopoietic Cell Transplantation for Children with JMML.

Research Funding

  • September 12, 2009 - August 31, 2024 - Primary Immune Deficiency Treatment Consortium , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54AI082973

Education

University of California at San Diego, BS, 1994, Molecular Biology
Vanderbilt University School of Medicine, MD, 1998, Medicine
Stanford University School of Medicine, Intern, 1999, Pediatrics
Stanford University School of Medicine, Resident, 2001, Pediatrics
Stanford University School of Medicine, Fellow, 2005, Hematology/Oncology

Honors & Awards

  • 1990-1994
    Regents Scholar, University of California at San Diego
  • 2002-2005
    Arline & Pete Harman Pediatric Fellow, Lucile Packard Foundation for Children's Health
  • 2011
    Pediatric Faculty Leadership Award, UCSF Fellow's College

Selected Publications

  1. Cuvelier GDE, Logan BR, Prockop SE, Buckley RH, Kuo CY, Griffith LM, Liu X, Yip A, Hershfield MS, Ayoub PG, Moore TB, Dorsey MJ, O'Reilly RJ, Kapoor N, Pai SY, Kapadia M, Ebens CL, Forbes Satter LR, Burroughs LM, Petrovic A, Chellapandian D, Heimall J, Shyr DC, Rayes A, Bednarski JJ, Chandra S, Chandrakasan S, Gillio AP, Madden L, Quigg TC, Caywood EH, Dávila Saldaña BJ, DeSantes K, Eissa H, Goldman FD, Rozmus J, Shah AJ, Vander Lugt MT, Thakar MS, Parrott RE, Martinez C, Leiding JW, Torgerson TR, Pulsipher MA, Notarangelo LD, Cowan MJ, Dvorak CC, Haddad E, Puck JM, Kohn DB. Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC. Blood. 2022 Aug 18; 140(7):685-705.  View on PubMed
  2. Chehab L, Doody DR, Esbenshade AJ, Guilcher GMT, Dvorak CC, Fisher BT, Mueller BA, Chow EJ, Rossoff J. A Population-Based Study of the Long-Term Risk of Infections Associated With Hospitalization in Childhood Cancer Survivors. J Clin Oncol. 2022 Jul 25; JCO2200230.  View on PubMed
  3. Pulsipher MA, Ahn KW, Bunin NJ, Lalefar NR, Anderson EJ, Flower A, Cairo MS, Talano JA, Chaudhury S, Kitko CL, Duke JL, Monos D, Leung W, Dvorak CC, Abdel-Azim H. KIR-Favorable TCR-αβ/CD19-Depleted Haploidentical HCT in Children with ALL/AML/MDS: Primary Analysis of PTCTC ONC1401. Blood. 2022 Jul 01.  View on PubMed
  4. Arnold DE, Chellapandian D, Parikh S, Mallhi K, Marsh RA, Heimall JR, Grossman D, Chitty-Lopez M, Murguia-Favela L, Gennery AR, Boulad F, Arbuckle E, Cowan MJ, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Notarangelo LD, Pai SY, Puck JM, Pulsipher MA, Torgerson T, Kang EM, Malech HL, Leiding JW. Granulocyte Transfusions in Patients with Chronic Granulomatous Disease Undergoing Hematopoietic Cell Transplantation or Gene Therapy. J Clin Immunol. 2022 07; 42(5):1026-1035.  View on PubMed
  5. Miller TP, Marx MZ, Henchen C, DeGroote NP, Jones S, Weiland J, Fisher B, Esbenshade AJ, Aplenc R, Dvorak CC, Fisher BT. Challenges and Barriers to Adverse Event Reporting in Clinical Trials: A Children's Oncology Group Report. J Patient Saf. 2022 Apr 01; 18(3):e672-e679.  View on PubMed
  6. Li S, Dvorak CC, Lu Y, Chan D, Gobburu JVS, Long-Boyle J, Apsel Winger B. Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation. J Clin Pharmacol. 2022 Jul; 62(7):873-882.  View on PubMed
  7. Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL. Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates. Sci Transl Med. 2022 03 09; 14(635):eabm8646.  View on PubMed
  8. Higham CS, Shimano KA, Melton A, Kharbanda S, Chu J, Dara J, Winestone LE, Hermiston ML, Huang JN, Dvorak CC. A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high-risk pediatric patients. Pediatr Blood Cancer. 2022 05; 69(5):e29641.  View on PubMed
  9. Bognàr T, Bartelink IH, Egberts TCG, Rademaker CMA, Versluys AB, Slatter MA, Kletzel M, Nath CE, Cuvelier GDE, Savic RM, Dvorak C, Long-Boyle JR, Cowan MJ, Bittencourt H, Bredius RGM, Güngör T, Shaw PJ, Ansari M, Hassan M, Krajinovic M, Hempel G, Marktel S, Chiesa R, Théoret Y, Lund T, Orchard PJ, Wynn RF, Boelens JJ, Lalmohamed A. Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther. 2022 04; 28(4):196-202.  View on PubMed
  10. Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E. Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature. Pediatr Blood Cancer. 2022 05; 69(5):e29499.  View on PubMed
  11. Brooks JT, Keizer RJ, Long-Boyle JR, Kharbanda S, Dvorak CC, Friend BD. Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation. Front Pharmacol. 2021; 12:750672.  View on PubMed
  12. Forlanini F, Zinter MS, Dvorak CC, Bailey-Olson M, Winestone LE, Shimano KA, Higham CS, Melton A, Chu J, Kharbanda S. Hematopoietic Cell Transplantation-Comorbidity Index Score Is Correlated with Treatment-Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplantation in Children. Transplant Cell Ther. 2022 03; 28(3):155.e1-155.e8.  View on PubMed
  13. Wintering A, Dvorak CC, Stieglitz E, Loh ML. Juvenile myelomonocytic leukemia in the molecular era: a clinician's guide to diagnosis, risk stratification, and treatment. Blood Adv. 2021 11 23; 5(22):4783-4793.  View on PubMed
  14. Kharbanda S, Dvorak CC. The Beginning of the End of Allogeneic Transplantation for Hurler Syndrome? N Engl J Med. 2021 11 18; 385(21):2003-2004.  View on PubMed
  15. Frederick NN, Klosky JL, Meacham LR, Quinn GP, Kelvin JF, Cherven B, Freyer DR, Dvorak CC, Brackett J, Ahmed-Winston S, Bryson E, Chow EJ, Levine J. Infrastructure of Fertility Preservation Services for Pediatric Cancer Patients: A Report From the Children's Oncology Group. JCO Oncol Pract. 2022 03; 18(3):e325-e333.  View on PubMed
  16. Fisher BT, Westling T, Boge CLK, Zaoutis TE, Dvorak CC, Nieder M, Zerr DM, Wingard JR, Villaluna D, Esbenshade AJ, Alexander S, Gunn S, Wheat LJ, Sung L. Prospective Evaluation of Galactomannan and (1→3) β-d-Glucan Assays as Diagnostic Tools for Invasive Fungal Disease in Children, Adolescents, and Young Adults With Acute Myeloid Leukemia Receiving Fungal Prophylaxis. J Pediatric Infect Dis Soc. 2021 Sep 23; 10(8):864-871.  View on PubMed
  17. Delmonte OM, Castagnoli R, Yu J, Dvorak CC, Cowan MJ, Dávila Saldaña BJ, De Ravin SS, Mamcarz E, Chang CK, Daley SR, Griffith LM, Notarangelo LD, Puck JM. Poor T-cell receptor β repertoire diversity early posttransplant for severe combined immunodeficiency predicts failure of immune reconstitution. J Allergy Clin Immunol. 2022 03; 149(3):1113-1119.  View on PubMed
  18. Marsh RA, Hebert K, Kim S, Dvorak CC, Aquino VM, Baker KS, Chellapandian D, Dávila Saldaña B, Duncan CN, Eckrich MJ, Georges GE, Olson TS, Pulsipher MA, Shenoy S, Stenger E, Lugt MV, Yu LC, Gennery AR, Eapen M. Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. J Allergy Clin Immunol. 2022 03; 149(3):1097-1104.e2.  View on PubMed
  19. Behnert A, Lee AG, Young EP, Breese MR, Leung SG, Behroozfard I, Maruffi M, Sweet-Cordero EA, Dvorak CC, Chu J, Stieglitz E. NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML. J Pediatr Hematol Oncol. 2021 08 01; 43(6):e808-e811.  View on PubMed
  20. Apsel Winger B, Long SE, Brooks J, Gupta AO, Dvorak CC, Long-Boyle JR. A Guidance for Concomitant Drug Reconciliation Prior to Allogeneic Hematopoietic Cell Transplantation in Children and Young Adults. Front Pediatr. 2021; 9:713091.  View on PubMed

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